IJCS | Volume 31, Nº3, May/ June 2018

295 Widera et al., 2013 20 Unstable angina, NSTEMI Unstable angina: increased levels of cardiac troponin. NSTEMI: increased levels or cardiac troponin, signs of ischemia in ECG, CAD, at least one 50% coronary stenosis 1146/ 74 (68-80) (with cardiac event) 69 (59-76) (without cardiac event) 6 months/ All-cause mortality, non-fatal infarction Immunoturbidimetry No Serum creatinine (mg/dL) = 1.20(0.90-1.65) (with cardiac event) Serum creatinine (mg/dL) = 0.93 (0.79-1.13) (without cardiac event) p < 0.001 Manzano -Fernández et al., 2012 21 Unstable angina, NSTEMI Chest pain ≥ 10 min within 72 hours before hospital admission and/or ST segment deviation or increased cardiac markers 226/ 58 ± 11 (1 st quartile) 64 ± 10 (2 nd quartile) 71 ± 10 (3 rd quartile) 76 ± 7 (4 th quartile) At least 12 months/ All-cause mortality Immunonephelometry No GFR = 92.1 ± 25.7 (1 st quartile) GFR = 85.9 ± 19.8 (2 nd quartile) GFR = 77.8 ± 14.2 (3 rd quartile) GFR = 54.8 ± 16.8 (4 th quartile) p ≤ 0.001 Ristiniemi et al., 2012 22 NSTEMI NI 245/ 62 (10.9) (1 st tertile) 69 (9.5) (2 nd tertile) 76 (8.8) (3 rd tertile) 12 months/ All-cause mortality non-fatal infarction Immunofluorescence No GFR = 76 (17.4) (1 st tertile) GFR = 62 (15.2) (2 nd tertile) GFR = 44 (15.5) (3 rd tertile) p < 0.0001 Silva et al., 2012 23 STEMI Chest pain at rest > 30 min, ST segment elevation in ECG or left bundle branch block 151/ 61 ± 12 12 months/ All-cause mortality, non-fatal infarction Immunonephelometry No GFR = 96.9 ± 37.1 (no death or infarction) GFR = 80.9 ± 25.3 (death or infarction) p > 0.05 Sun et al., 2012 24 Unstable angina, NSTEMI, STEMI NI 660 patients/ 62.5 ± 10.5 (with cardiac event) 59.9 ± 10.6 (without cardiac event) At least 12 months/ All-cause mortality, non-fatal infarction, need of revascularization, CHF, recurrent chest angina, stroke Immunoturbidimetry No GFR = 96.00 (with cardiac event) GFR = 104.08 (without cardiac event) p = 0.057 Kaski et al., 2010 25 Unstable angina, NSTEMI Chest pain at rest > 5 min, and ≥ 1 of these criteria: signs of myocardial ischemia in ECG, CAD and/ or myocardial revascularization with PCI or bypass surgery; increased cardiac troponin 610/ 67.2 ± 10.9 (with cardiac event) 64.5 ± 11.3 (without cardiac event) 12 months/ All-cause mortality, non-fatal infarction Immunonephelometry No GFR = 74 (58-87) (with cardiac event) GFR = 78 (64-94) (without cardiac event) p = 0.05 Martucheli et al. Cystatin C and acute coronary syndromes International Journal of Cardiovascular Sciences. 2018;31(3)290-307 Review Article