IJCS | Volume 31, Nº3, May/ June 2018

294 Table 1 - Characteristics of the selected studies Author/ Year Type of acute coronary syndrome Diagnostic method for acute coronary syndrome Number of patients / Age range (years) Time of follow- up / Outcome measure Method of cystatin C measurement Inclusion of patients with normal kidney function only GFR of patients (mL/ min/1,73m 2 ) or serum creatinine Studies included only in the systematic review and meta-analysis Tonkin et al., 2015 15 Unstable angina, NSTEMI, STEMI NI 9014/ 31-75 5 years/ Cardiovascular death, non-fatal infarction Immunoturbidimetry Yes GFR = 69 (60-80) Akerblom et al., 2012 16 NSTEMI, STEMI NSTEMI: at least two of these criteria: change in ST segment; increase in cardiac marker levels; presence of one of the risk factors. STEMI: at least two of the following criteria: ST segment elevation in ECG; recent left bundle branch block; intention to perform primary PCI. 16401/ 57 (51-64) (1 st quartile) 59 (52-67) (2 nd quartile) 63 (56-71) (3 rd quartile) 70 (61-76) (4 th quartile) 12 months/ Cardiovascular death, non-fatal infarction Immunoturbidimetry No GFR = 82,6 Studies included only in the systematic review Tang et al., 2015 17 STEMI Chest pain > 30 min, ST segment elevation in ECG; recent left bundle branch block; increase in cardiac markers 108/ 58.8 ± 9.8 (cystatin C < 1.36 mg/L) 65.9 ± 11.3 (cystatin C ≥ 1.36 mg/L) 6 months/ Cardiovascular death, non-fatal infarction, need of revascularization, stroke and CHF Immunoturbidimetry No GFR = 81.6 ± 22.5 (cystatin C ≥ 1.36 mg/L) GFR = 99.5 ± 20.8 (cystatin C < 1.36 mg/L) p = 0.01 Fu et al., 2013 18 Unstable angina, NSTEMI, STEMI NI 660/ 81.74 ± 2.54 (group with diabetes) 81.99 ± 2.21 (group without diabetes) 28 months/ All-cause mortality, myocardial infarction, need of revascularization NI No GFR = 68.67 (55.97–82.14) (with DM) GFR = 72.55 (63.08-81.74) (without DM) p = 0.106 Akgul et al., 2013 19 STEMI Chest pain > 30 min, ST segment elevation in ECG 475/ 62.8 ± 13.1 (3 rd quartile) 52.3 ± 10.5 (1 st and 2 nd quartiles) 1 month/ Cardiovascular death, non-fatal infarction, need of revascularization Immunoturbidimetry No GFR = 70.6 ± 24.3 (cystatin C > 1.12 mg/L) GFR = 98.1 ± 22.8 (cystatin C ≤ 1.12 mg/L) p < 0.001 Martucheli et al. Cystatin C and acute coronary syndromes International Journal of Cardiovascular Sciences. 2018;31(3)290-307 Review Article