ABC | Volume 115, Nº1, Julho 2020

Artigo Original Silva-Bertani et al. Mecanismo da redução do colágeno I no coração obeso Arq Bras Cardiol. 2020; 115(1):61-70 Este é um artigo de acesso aberto distribuído sob os termos da licença de atribuição pelo Creative Commons 36. Yang R, Barouch LA. Leptin signaling and obesity: cardiovascular consequences. Circ Res. 2007;101(6):545–59. 37. Srinivasan SR, BaoW, WattigneyWA, Berenson GS. Adolescent overweight is associated with adult overweight and related multiple cardiovascular risk factors: the Bogalusa Heart Study. Metabolism. 1996;45(2):235–40. 38. Fitzgerald SM, Henegar JR, BrandsMW, Henegar LK, Hall JE. Cardiovascular and renal responses to a high-fat diet in Osborne-Mendel rats. Am J Physiol Regul Integr Comp Physiol. 2001;281(2):R547-52. 39. Martínez-Martínez E, Jurado-López R, Valero-Muñoz M, Bartolomé MV, Ballesteros S, Luaces M, et al. Leptin induces cardiac fibrosis through galectin-3, mTOR and oxidative stress: potential role in obesity. J Hypertens. 2014;32(5):1104–14; discussion 1114. 40. Hori Y, Kashimoto T, Yonezawa T, Sano N, Saitoh R, Igarashi S, et al. Matrix metalloproteinase-2 stimulates collagen-I expression through phosphorylation of focal adhesion kinase in rat cardiac fibroblasts. Am J Physiol Cell Physiol. 2012;303(9):C947-53. 41. Laviades C, Varo N, Fernández J, Mayor G, Gil MJ, Monreal I, et al. Abnormalities of the extracellular degradation of colágeno tipo I in essential hypertension. Circulation. 1998;98(6):535–40. 70