ABC | Volume 115, Nº1, Julho 2020

Artigo Original Silva-Bertani et al. Mecanismo da redução do colágeno I no coração obeso Arq Bras Cardiol. 2020; 115(1):61-70 1. World Health Organization.(WHO). Fact sheets: Obesity and overweight (Internet). (Cited 2018 Jan 18). Available from: https://www.who.int/news- room/fact-sheets/detail/obesity-and-overweight. 2. Bhurosy T, Jeewon R. Overweight and obesity epidemic in developing countries: a problem with diet, physical activity, or socioeconomic status? Scient World J. 2014;2014:964236. 3. Hall ME, Harmancey R, Stec DE. Lean heart: Role of leptin in cardiac hypertrophy and metabolism. World J Cardiol. 2015;7(9):511–24. 4. Segura AM, Frazier OH, Buja LM. Fibrosis and heart failure. Heart Fail Rev. 2014;19(2):173–85. 5. Berg G, Schreier L, Miksztowicz V. Circulating and adipose tissue matrix metalloproteinases in cardiometabolic risk environments: pathophysiological aspects. HormMol Biol Clin Investig. 2014;17(2):79–87. 6. Matsubara LS, Narikawa S, Ferreira ALA, Paiva SA, Zornoff LM et al. Remodelação miocárdica na sobrecarga crônica de pressão e volume no coração de ratos. Arq Bras Cardiol. 2006;86(2):126-30. 7. Alberts B, Johnson A, Lewis J, Raff M, Roberts K et al. Junções celulares, adesão celular e matriz extracelular. In: Alberts B. Biologia molecular da célula. 5th ed. Porto Alegre: Artmed; 2010. 1131–204 p. 8. Berk BC, Fujiwara K, Lehoux S. MEC remodeling in hypertensive heart disease. J Clin Invest. 2007;117(3):568–75. 9. SzczęsnyW, Szczepanek J, Tretyn A, Dąbrowiecki S, Szmytkowski J, Polak J. An analysis of the expression of collagen I and III genes in the fascia of obese patients. J Surg Res. 2015 May;195(2):475–80. 10. Lancha A, Rodríguez A, Catalán V, Becerril S, Sáinz N, Ramírez B, et al. Osteopontin deletion prevents the development of obesity and hepatic steatosis via impaired adipose tissue matrix remodeling and reduced inflammation and fibrosis in adipose tissue and liver in mice. PLoS One. 2014;9(5):e98398. 11. Minullina IR, AlexeyevaNP, Anisimov S V, PuzanovMV, Kozlova SN, Sviryaev Y V, et al. Transcriptional changes in bone marrow stromal cells of patients with heart failure. Cell Cycle. 2014;13(9):1495–500. 12. Carroll JF, Tyagi SC. Extracellular matrix remodeling in the heart of the homocysteinemic obese rabbit. Am J Hypertens. 2005;18(5 Pt 1):692–8. 13. Silva DCT da, Lima-Leopoldo AP, Leopoldo AS, Campos DHS de, Nascimento AF do, Oliveira Junior SA de, et al. Influence of termof exposure to high-fat diet-induced obesity on colágeno miocárdico tipo I and III. Arq Bras Cardiol. 2014;102(2):157–63. 14. Zibadi S, Cordova F, Slack EH, Watson RR, Larson DF. Leptin’s regulation of obesity-induced cardiac extracellular matrix remodeling. Cardiovasc Toxicol. 2011;11(4):325–33. 15. SchramK, De Girolamo S, Madani S, Munoz D, Thong F, Sweeney G. Leptin regulates MMP-2, TIMP-1 and collagen synthesis via p38 MAPK in HL-1 murine cardiomyocytes. Cell Mol Biol Lett. 2010;15(4):551–63. 16. Schram K, Ganguly R, No EK, Fang X, Thong FSL, Sweeney G. Regulation of MT1-MMP and MMP-2 by leptin in cardiac fibroblasts involves Rho/ ROCK-dependent actin cytoskeletal reorganization and leads to enhanced cell migration. Endocrinology. 2011;152(5):2037–47. 17. Deus AF, Vileigas DF, Silva DCT, Tomasi LC, Campos DHS, Okoshi K, et al. Cardiac function and intracellular Ca2+ handling proteins are not impaired by high-saturated-fat diet-induced obesity. Braz J Med Biol Res. 2019;52(6):e8085. 18. Jacobsen BB, Leopoldo APL, Cordeiro JP, Campos DHS de, Nascimento AF do, Sugizaki MM, et al. Cardiac, Metabolic and Molecular Profiles of Sedentary Rats in the Initial Moment of Obesity. Arq Bras Cardiol. 2017;109(5):432-9. 19. Vileigas DF, de Deus AF, da Silva DCT, de Tomasi LC, de Campos DHS, Adorni CS, et al. Saturated high-fat diet-induced obesity increases adenylate cyclaseofmyocardialβ-adrenergicsystemanddoesnotcompromisecardiac function. Physiol Rep. 2016;4(17):pii e12914. 20. National Institute of Health. Guide for the care and use of laboratoty animals. [Contract NOI-RR-2-2135]. Bethesda:Animal Resources Program. Division of Research Resources;1985. 21. Rodríguez-Calvo R, Girona J, Alegret JM, Bosquet A, Ibarretxe D, Masana L. Role of the fatty acid-binding protein 4 in heart failure and cardiovascular disease. J Endocrinol. 2017;233(3):R173–84. 22. Zhang J, Qiao C, Chang L, Guo Y, Fan Y, Villacorta L, et al. Cardiomyocyte Overexpression of FABP4 Aggravates Pressure Overload-Induced Heart Hypertrophy. PLoS One. 2016;11(6):e0157372. 23. Aasum E, Khalid AM, Gudbrandsen OA, How O-J, Berge RK, Larsen TS. Fenofibrate modulates cardiac and hepatic metabolism and increases ischemic tolerance in diet-induced obese mice. J Mol Cell Cardiol. 2008;44(1):201–9. 24. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations inman. Diabetologia. 1985;28(7):412–9. 25. Santos PP Dos, Rafacho BPM, Gonçalves A de F, Jaldin RG, Nascimento TB do, Silva MAB, et al. Vitamin D induces increased systolic arterial pressure via vascular reactivity and mechanical properties. PLoS One. 2014;9(6):e98895. 26. Tyagi SC, Matsubara L, Weber KT. Direct extraction and estimation of collagenase(s) activity by zymography inmicroquantities of rat myocardium and uterus. Clin Biochem. 1993;26(3):191–8. 27. Nascimento AF, Luvizotto RAM, Leopoldo AS, Lima-Leopoldo AP, Seiva FR, Justulin LA, et al. Long-term high-fat diet-induced obesity decreases the cardiac leptin receptor without apparent lipotoxicity. Life Sci. 2011;88(23– 24):1031–8. 28. Lima-Leopoldo AP, Leopoldo AS, Sugizaki MM, Bruno A, Nascimento AF, Luvizotto RAM, et al. Disfunçãomiocárdica e alterações no trânsito de cálcio intracelular em ratos obesos. Arq Bras Cardiol. 2011;97(3):232–40. 29. Carroll JF, ZenebeWJ, Strange TB. Cardiovascular function in a rat model of diet-induced obesity. Hypertens (Dallas, Tex 1979). 2006;48(1):65–72. 30. Jéquier E. Pathways to obesity. Int J Obes Relat MetabDisord. 2002;26 Suppl 2:S12-7. 31. Nivoit P, Morens C, Van Assche FA, Jansen E, Poston L, Remacle C, et al. Establisheddiet-inducedobesity infemalerats leadstooffspringhyperphagia, adiposity and insulin resistance. Diabetologia. 2009;52(6):1133–42. 32. Relling DP, Esberg LB, Fang CX, Johnson WT, Murphy EJ, Carlson EC, et al. High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis. J Hypertens. 2006;24(3):549–61. 33. Omar B, Pacini G, Ahrén B. Differential development of glucose intolerance and pancreatic islet adaptation in multiple diet induced obesity models. Nutrients. 2012;4(10):1367–81. 34. Leopoldo AS, Lima-Leopoldo AP, Sugizaki MM, do Nascimento AF, de Campos DHS, Luvizotto R de AM, et al. Involvement of L-type calcium channel and SERCA2a in myocardial dysfunction induced by obesity. J Cell Physiol. 2011;226(11):2934–42. 35. Ferron AJT, Jacobsen BB, Sant’Ana PG, de Campos DHS, de Tomasi LC, Luvizotto R de AM, et al. Cardiac Dysfunction Induced by Obesity Is Not Related to β -Adrenergic System Impairment at the Receptor-Signalling Pathway. PLoS One. 2015;10(9):e0138605. Referências 69