ABC | Volume 115, Nº1, Julho 2020

Artigo Original Oliveira-Junior et al. Efeitos do losartan na obesidade Arq Bras Cardiol. 2020; 115(1):17-28 Vinculação acadêmica Este artigo é relacionado ao tema da dissertação de Mestrado de Nayara de Araújo Muzili pela Universidade Federal de Mato Grosso do Sul. 1. Azevedo PS, Minicucci MF, Zornoff LAM. Obesity: a growing multifaceted problem. Arq Bras Cardiol. 2015;105(5):448-9. 2. Nunes CNM, Minicucci MF, Farah E, Fusco D, Azevedo PS, Paiva SAR, et al. Impact of different obesity assessment methods after acute coronary syndromes. Arq Bras Cardiol. 2014;103(1):19-24. 3. Gonçalves N, Silva AF, Rodrigues PG, Correia E, Moura C, Eloy C, et al. Early cardiacchanges inducedbyahypercaloricWestern-typediet in“subclinical” obesity. Am J Physiol Heart Circ Physiol. 2016;310(6):H655–66. 4. Alpert MA, Karthikeyan K, Abdullah O, Ghadban R. Obesity and Cardiac remodeling in adults: mechanisms and clinical implications. Prog Cardiovasc Dis. 2018;61(2):114-23. 5. de Cleva R, Araujo VA, Buchalla CCO, de Oliveira Costa F, Cardoso AF, Pajecki D, et al. Cardiac remodeling patterns in severe obesity according to arterial hypertension grade. Obes Surg. 2018;28(4):1047-54. 6. Oliveira-Junior SA, Dal Pai M, Guizoni DM, Torres BP, Martinez PF, Campos DHS, et al. Effects of AT1 receptor antagonism on interstitial and ultrastructural remodeling of heart in response to a hypercaloric diet. Physiol Rep. 2019;7(1):e13964. 7. Lima-Leopoldo AP, Leopoldo AS, Sugizaki MM, Bruno A, Nascimento AF, Luvizotto RA, et al. Myocardial dysfunction and abnormalities in intracellular calcium handling in obese rats. Arq Bras Cardiol. 2011;97(3):232–40. 8. Oliveira Junior SA, Padovani CR, Rodrigues SA, Silva NR, Martinez PF, Campos DHS, et al. Extensive impact of saturated fatty acids on metabolic and cardiovascular profile in rats with diet-induced obesity: a canonical analysis. Cardiovasc Diabetol. 2013;12(1):65. 9. Martins F, Campos DHS, Pagan LU, Martinez PF, Okoshi K, Okoshi MP, et al. Dieta hiperlipídica promove remodelação cardíaca em modelo experimental de obesidade. Arq Bras Cardiol. 2015;105(5):479-86. 10. Oliveira Junior SA, Dal Pai-Silva M, Martinez PF, Campos DHS, Lima- Leopoldo AP, et al. Differential nutritional, endocrine, and cardiovascular effects in obesity-prone and obesity-resistant rats fed standard and hypercaloric diets. Med Sci Monit. 2010;16(7):BR208–217a. 11. Oliveira-Junior SA, Martinez PF, Guizoni DM, Campos DHS, Fernandes T, Oliveira EM, et al. AT1 receptor blockade attenuates insulin resistance and myocardial remodeling in rats with diet-induced obesity. Plos One. 2014;9(1): e86447. 12. Lima-Leopoldo AP, Leopoldo AS, Silva DCT, Nascimento AF, Campos DHS, Luvizotto RAM, et al. Influence of long-term obesity on myocardial gene expression. Arq Bras Cardiol. 2013;100(3):229-37. 13. Lima-Leopoldo AP, Leopoldo AS, da Silva DC, do Nascimento AF, de Campos DH, Luvizotto RA, et al. Long-termobesity promotes alterations in diastolic function induced by reduction of phospholamban phosphorylation at serine-16 without affecting calcium handling. J Appl Physiol (1985). 2014;117(6):669-78. 14. da Silva VL, Lima-Leopoldo AP, Ferron AJT, Cordeiro JP, Freire PP, de Campos DHS, et al. Moderate exercise training does not prevent the reduction in myocardial L-type Ca2+ channels protein expression at obese rats. Physiol Rep. 2017;5(19):e13466. 15. Jacobsen BB, Leopoldo APL, Cordeiro JP, Campos DHS, Nascimento AFD, Sugizaki MM, et al. Cardiac, metabolic and molecular profiles of sedentary rats in the initial moment of obesity. Arq Bras Cardiol. 2017;109(5):432-9. 16. Vileigas DF, de Deus AF, da Silva DCT, Tomasi LC, Campos DHS, Adorni CS, et al. Saturated high-fat diet-induced obesity increases adenylate cyclase of myocardial b-adrenergic systemand does not compromise cardiac function. Physiol Rep. 2016;4(17):e12914. 17. Leopoldo AS, Lima-Leopoldo AP, Sugizaki MM, do Nascimento AF, de Campos DH, Luvizotto Rde A, et al. Involvement of L-type calcium channel and SERCA2a in myocardial dysfunction induced by obesity. J Cell Physiol. 2011:226(11):2934-42. 18. Ferron AJT, Jacobsen BB, Sant’Ana PG, Campos DHS, Tomasi LC, Luvizotto RAM, et al. Cardiac dysfunction induced by obesity is not related to β -adrenergic system impairment at the receptor-signaling pathway. Plos One. 2015;10(9):e0138605. 19. Campos DH, Leopoldo AS, Lima-Leopoldo AP, Nascimento AF, Oliveira- Junior SA, Silva DC, et al. Obesity preserves myocardial function during blockade of the glycolytic pathway. Arq Bras Cardiol. 2014;103(4):330-7. 20. Schütten MT, Houben AJ, de Leeuw PW, Stehouwer CD. The link between adipose tissue renin-angiotensin-aldosterone system signaling and obesity- associated hypertension. Physiology (Bethesda). 2017;32(3):197-209. 21. du Toit EF, NabbenM, Lochner A. A potential role for angiotensin II in obesity induced cardiac hypertrophy and ischaemic/reperfusion injury. Basic Res Cardiol. 2005;100(4):346-54. 22. Yoshida T, Tabony AM, Galvez S, Mitch WE, Higashi Y, Sukhanov S, et al. Molecular mechanisms and signaling pathways of angiotensin II induced muscle wasting: potential therapeutic targets for cardiac cachexia. Int J Biochem Cell Biol. 2013;45(10):2322-32. 23. RamalingamL, Menikdiwela K, LeMieuxM, Dufour JM, Kaur G, Kalupahana N, et al. The renin angiotensin system, oxidative stress and mitochondrial function in obesity and insulin resistance. Biochim Biophys Acta Mol Basis Dis. 2017;1863(5):1106-14. 24. Müller-Fielitz H, Landolt J, Heidbreder M, Werth S, Vogt FM, Jöhren O, et al. Improved insulin sensitivity after long-term treatment with AT1 blockers is not associated with PPAR γ target gene regulation. Endocrinology. 2012;153(1):1103–15. 25. Silva DCT, Lima-Leopoldo AP, Leopoldo AS, Campos DHS, Nascimento AF, Oliveira Junior SA, et al. Influence of term of exposure to high-fat diet- induced obesity on myocardial collagen type I and III. Arq Bras Cardiol. 2014; 102(2):157-63. 26. Pfeffer JM, Pfeffer MA, Frohlich ED. Validity of an indirect tail-cuff method for determining systolic arterial pressure in unanesthetized normotensive and spontaneously hypertensive rats. J Lab Clin Med. 1971;78(6):957-8. 27. Martinez PF, Okoshi K, Zornoff LAM, Oliveira Jr SA, Campos DHS, Lima ARR, et al. Echocardiographic detection of congestive heart failure in postinfarction rats. J Appl Physiol. 2011;111(2):543-51. 28. Sahn DJ, De Maria A, Kisslo J, Weyman A. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation. 1978;58(6):1072–83. 29. Cezar MDM, Damatto RL, Pagan LU, Lima ARR, Martinez PF, Bonomo C, et al. Early spironolactone treatment attenuates heart failure development by improving myocardial function and reducing fibrosis in spontaneously hypertensive rats. Cell Physiol Biochem 2015;36(4):1453-66. Referências Aprovação ética e consentimento informado Este estudo foi aprovado pelo Comitê de Ética no Uso de Animais da UNESP sob o número de protocolo 1000/2013. Todos os procedimentos envolvidos nesse estudo estão de acordo com a Declaração de Helsinki de 1975, atualizada em 2013. 27