ABC | Volume 114, Nº6, Junho 2020

Artigo de Revisão Figueiredo Neto et al. Coronavírus e o Miocárdio Arq Bras Cardiol. 2020; 114(6):1051-1057 Em resumo, o elevado grau de suspeita clínica com dor torácica, alteração hemodinâmica e/ou alterações do ST e/ou arritmias no ECG, associadas a anormalidades morfofuncionais nos métodos de cardioimagem e elevação da troponina cardíaca, representam os pilares do raciocínio clínico para a presença da agressão miocárdica aguda na atual pandemia por coronavírus. Adicionalmente, torna-se necessário a cardiovigilância destes pacientes, posto que, à luz dos conhecimentos atuais, não sabemos se eles poderão ou não evoluir com disfunção miocárdica tardia. Contribuição dos autores Concepção e desenho da pesquisa, Análise e interpretação dos dados, Redação do manuscrito e Revisão crítica do manuscrito quanto ao conteúdo intelectual importante: Figueiredo Neto JA, Marcondes F, Moura L, Rocha RM, Mesquita ET; Obtenção de dados: Figueiredo Neto JA, Marcondes F, Moura L, Figueiredo AMS, Figueiredo VMS, Rocha RM, Mesquita ET. Potencial conflito de interesses Os autores declaram não haver conflito de interesses pertinentes. Fontes de financiamento Opresente estudo não contou com fontes de financiamento externas. Vinculação acadêmica Não há vinculação deste estudo a programas de pós- graduação. 1. Guan WJ, Liang WH, Zhao Y, et al. China Medical Treatment Expert Group for Covid-19. Comorbidity and its impact on 1590 patients with Covid-19 in China: A Nationwide Analysis. Eur Respir J. 2020 Mar 26; 2000547. doi: 10.1183/13993003.00547-2020 [Epub ahead of print]. 2. HoffmannM, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell. 2020;181(2):271-80. 3. ZhaoY,ZhaoZ,WangY,ZhouY,MaY,ZuoW.Single-cellRNAexpressionprofiling ofACE2,theputativereceptorofWuhan2019-nCov.bioRxiv.2020Jan26. 4. Turner AJ, Hiscox JA, Hooper NM. ACE2: from vasopeptidase to SARS virus receptor. Trends Pharmacol Sci. 2004;25(6):291-4. 5. Imai Y, Kuba K, Rao S, Huan Y, Guo F, Guan B, et al. Angiotensin- converting enzyme 2 protects from severe acute lung failure. Nature. 2005;436(7047):112-6. 6. Costa IBSS, Bittar, CS, Rizk SI, Araújo Filho AE, Santos KAQ, Machado TIV, et al. The heart and COVID-19: what cardiologists need to know.. Arq Bras Cardiol. 2020 May 11. [Epub ahead of print]. 7. Shi S, Qin M, Shen B, Cai Y, Liu T, Yang F, et al. Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China. JAMA Cardiol. 2020. [Published online 2020 March 25] doi: 10.1001/ jamacardio.2020 Mar 25. [Epub ahead of print]. 8. Guo T, Fan Y, Chen M. Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19). JAMA Cardiol. 2020 Mar 27. [Epub ahead of print]. 9. Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054-62. 10. Atri D, Siddidi HK, Lang J, Nauffal V, Morrow DA, Bohula EA. COVID-19 for the cardiologist: a current review of the virology, clinical epidemiology, cardiac and other clinical manifestations and potential therapeutic strategies. JACC Basic Transl Sci. 2020 Apr 10. [Epub ahead of print]. 11. Sarkisian L, Saaby L, Poulsen TS et al. Prognostic impact of myocardial injury related to various cardiac and noncardiac conditions. Am J Med. 2016;129(5):506-14.e1. 12. Libby P, Loscalzo J, Ridker P, Farkouh ME, Hsue PY, Fuster V, et al. Inflammation, immunity, and infection in atherothrombosis: JACC Review Topic of the Week. J Am Coll Cardiol. 2018;72(17):2071-81. 13. Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, MorrowDA, et al. Fourth Universal Definition of Myocardial Infarction (2018). J Am Coll Cardiol. 2018;72(18):2231-64. 14. ChapmanAR,ShahASV,LeeKK,AnandA,FrancisO,AdamsonP,etal.Long-term outcomes in patients with type 2 myocardial infarction and myocardial injury. Circulation.2018;137(12):1236-45. 15. Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost.2020;18(4):844-7. 16. Simmons J, Pittet JF. The coagulopathy of acute sepsis. Curr Opin Anaesthesiol. 2015;28(2):227-36. 17. Levi M, van der Poll T, Buller HR. Bidirectional relation between inflammation andcoagulation.Circulation.2004;109(22):2698-704. 18. Green J, Doughty L, Kaplan SS, Sasser H, Carcillo JA. The tissue factor and plasminogen activator inhibitor type-1 response in pediatric sepsis-induced multipleorgan failure.ThrombHaemost.2002;87(2):218-23. 19. Cox D, Kerrigan SW, Watson SP. Platelets and the innate immune system: mechanisms of bacterial-induced platelet activation. J Thromb Haemost. 2011;9(6):1097-107. 20. Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, et al. Dysregulation of immune responseinpatientswithCOVID-19inWuhan,China.ClinInfectDis.2020Mar 12. [Epubaheadofprint]. 21. KumarA,ThotaV,DeeL,OlsonJ,UretzE,ParrilloJE.Tumornecrosisfactoralpha and interleukin 1beta are responsible for in vitro myocardial cell depression inducedbyhumansepticshockserum. JExpMed.1996;183(3):949-58. 22. Natanson C, Eichenholz PW, Danner RL, Eichacker PQ, Hoffman WD, Kuo GC, et al. Endotoxin and tumor necrosis factor challenges indogs simulate the cardiovascularprofileofhumansepticshock. JExpMed.1989;169(3):823-32. 23. PathanN, Hemingway CA, Alizadeh AA, Stephens AC, Boldrick JC, Oragui EE, et al. Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock.Lancet.2004;363(9404):203-9. 24. Hobai IA, Edgecomb J, LaBarge K, Colucci WS. Dysregulation of intracellular calciumtransportesinanimalmodelsofsepsis-inducedcardiomyopathy.Shock. 2015;43(1):3-15. 25. Balligand JL, Ungureanu D, Kelly RA, Kobzik L, Pimental D, Michel T, et al. Abnormal contractile function due to induction ofnitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage conditioned medium. JClin Invest.1993;91(5):2314-9. Referências 1056