ABC | Volume 113, Nº6, Dezembro 2019

Artigo Original Barbosa et al Nrf2, NF- κ B e PPAR β / δ em pacientes com DAC Arq Bras Cardiol. 2019; 113(6):1121-1127 Este é um artigo de acesso aberto distribuído sob os termos da licença de atribuição pelo Creative Commons 36. Ishikawa K, Maruyama Y. Heme oxygenase as an intrinsic defense system in vascular wall: implication against atherogenesis. J Atheroscler Thromb. 2001;8(3):63–70. 37. Jyrkkänen H-K, Kansanen E, Inkala M, Kivelä AM, Hurttila H, Heinonen SE, et al. Nrf2 regulates antioxidant gene expression evoked by oxidized phospholipids in endothelial cells and murine arteries in vivo. Circ Res. 2008;103(1):e1–9. 38. Moon GJ, Kim SJ, Cho YH, Ryoo S, Bang OY. Antioxidant effects of statins in patients with atherosclerotic cerebrovascular disease. J Clin Neurol. 2014;10(2):140–7. 39. IvanovM, Mihailović-Stanojević N, GrujićMilanović J, Jovović Đ , Marković- Lipkovski J, Ćirović S, et al. Losartan improved antioxidant defense, renal function and structure of postischemic hypertensive kidney. PloS One. 2014;9(5):e96353. 40. Suh JH, Shenvi SV, Dixon BM, Liu H, Jaiswal AK, Liu R-M, et al. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Natl Acad Sci U S A. 2004;101(10):3381–6. 41. Fiorentino TV, Prioletta A, Zuo P, Folli F. Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases. Curr PharmDes. 2013;19(32):5695–703. 42. Wagner KD, Vukolic A, Baudouy D, Michiels JF, Wagner N. Inducible Conditional Vascular-Specific Overexpression of Peroxisome Proliferator- Activated Receptor Beta/Delta Leads to Rapid Cardiac Hypertrophy. PPAR Res. 2016;2016:7631085. 43. Burkart EM, Sambandam N, Han X, Gross RW, Courtois M, Gierasch CM, et al. Nuclear receptors PPARbeta/delta and PPARalpha direct distinct metabolic regulatory programs in the mouse heart. J Clin Invest. 2007;117(12):3930–9. 44. Tan NS, Michalik L, Noy N, Yasmin R, Pacot C, HeimM, et al. Critical roles of PPAR beta/delta in keratinocyte response to inflammation. Genes Dev. 2001;15(24):3263–77. 45. Jiang B, Liang P, Zhang B, Huang X, Xiao X. Enhancement of PPAR-beta activity by repetitive low-grade H(2)O(2) stress protects human umbilical vein endothelial cells from subsequent oxidative stress-induced apoptosis. Free Radic Biol Med. 2009;46(5):555–63. 46. Reuland DJ, McCord JM, Hamilton KL. The role of Nrf2 in the attenuation of cardiovascular disease. Exerc Sport Sci Rev. 2013;41(3):162–8. 47. Cardozo LF, Pedruzzi LM, Stenvinkel P, Stockler-Pinto MB, Daleprane JB, LeiteM, et al. Nutritional strategies tomodulate inflammation and oxidative stress pathways via activation of the master antioxidant switch Nrf2. Biochimie. 2013;95(8):1525–33. 1127

RkJQdWJsaXNoZXIy MjM4Mjg=