ABC | Volume 113, Nº5, Novembro 2019

Artigo Original Muniz et al. Distúrbios metabólicos em um modelo de dislipidemia modificada Arq Bras Cardiol. 2019; 113(5):896-902 Este é um artigo de acesso aberto distribuído sob os termos da licença de atribuição pelo Creative Commons 13. ReevesPG,NielsenFN,FaheyJrGC.AIN-93purifieddietsforlaboratoryrodents: final report of the American institute of nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993;123(11):1939-51. 14. Takahashi Y, Soejima Y, Fukusato T. Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. World J Gastroenterol, 2012;18(19):2300-9. 15. National Research Council. Guide for the care and use of laboratory animal, Washington, DC: The National Academies Press, 2011. 16. Boekholdt SM, Arsenault BJ, Mora S, Pedersen TR, LaRosa JC, Nestel PJ, et al. Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis. JAMA 2012;307(12):1302e9. 17. van Herpen NA, Schrauwen-Hinderling VB, Schaart G, Mensink RP, Schrauwen P. Three weeks on a high-fat diet increases intrahepatic lipid accumulation and decreases metabolic flexibility in healthy overweight men. J Clin Endocrinol Metab. 2011;96(4):E691-5. 18. von Frankenberg AD, Marina A, Song X, CallahanHS, KratzM, Utzschneider KM. A high-fat, high-saturated fat diet decreases insulin sensitivity without changing intra-abdominal fat inweight-stable overweight and obese adults. Eur J Nutr. 2017;56(1):431-43. 19. Utzschneider KM, Bayer-Carter JL, Arbuckle MD, Tidwell JM, Richards TL, Craft S. Beneficial effect of a weight-stable, low-fat/low-saturated fat/ low-glycaemic index diet to reduce liver fat in older subjects. Br J Nutr. 2013;109(6):1096-104. 20. Institute of Medicine. Dietary Reference Intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids,Washington, DC: The National Academies Press, 2005. 21. Zárate A, Manuel-Apolinar L, Saucedo R, Hernández-Valencia M, Basurto L. Hypercholesterolemia as a risk factor for cardiovascular disease: current controversial therapeutic management. Arch Med Res . 2016;47(7):491-5. 22. Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Saturated fat, carbohydrate, and cardiovascular disease. Am J Clin Nutr. 2010;91(3):502-9. 23. Kuipers RS, Graaf DJ, Luxwolda MF, Muskiet MH, Dijck-Brouwer DA, Muskiet FA. Saturated fat, carbohydrates and cardiovascular disease. Neth J Med . 2011;69(9):372-8. 24. Siri-TarinoPW,SunQ,HuFB,KraussRM.Meta-analysisofprospectivecohort studiesevaluatingtheassociationofsaturated fatwithcardiovasculardisease. Am J Clin Nutr . 2010;91(3):535-46. 25. Vetelainen R, van Vliet AK, van Gulik TM. Severe steatosis increases hepatocellular injury and impairs liver regeneration in a rat model of partial hepatectomy. Ann Surg. 2007;245(1):44-50. 26. Musso G, Gambino R, Cassader M. Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis. Prog Lipid Res . 2013;52(1):175-91. 27. Birkenfeld AL, Shulman GI. Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes. Hepatology. 2014;59(2):713-23. 28. Perry RJ, Samuel VT, Petersen KF, Shulman GI. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature. 2014;510(7503):84-91. 29. Lau JK, Zhang X, Yu J. Animal models of non-alcoholic fatty liver disease: current perspectives and recent advances. J Pathol . 2017;241(1):36-44. 30. Matsuzawa N, Takamura T, Kurita S, Misu H, Ota T, Ando H, et al. Lipid- induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet. Hepatology. 2007;46(5):1392-403. 31. Vergnes L, Phan J, Strauss M, Tafuri S, Reue K. Cholesterol and cholate components of an atherogenic diet induce distinct stages of hepatic inflammatory gene expression. J Biol Chem. 2003;278(44):42774-784. 32. Asrih M, Jornayvaz FR. Diets and nonalcoholic fatty liver disease: the good and the bad. Clin Nutr. 2014;33(2):186-190. 33. Polyzos SA, Kountouras J, Mantzoros CS. Adipokines in nonalcoholic fatty liver disease. Metabolism. 2016;65(8):1062-79. 34. Cui CX, Deng JN, Yan L, Liu YY, Fan JY, Um HN, et al. Silibinin capsules improves high fat diet-induced nonalcoholic fatty liver disease in hamsters through modifying hepatic de novo lipogenesis and fatty acid oxidation. J Ethnopharmacol . 2017 Aug;208:24-35. 35. Hu X, Wang T, Liang S, Li W, Wu X, Jin F. Antibiotic-induced imbalances in gut microbiota aggravates cholesterol accumulation and liver injuries in rats fed a high-cholesterol diet. Appl Microbiol Biotechnol . 2015;99(21):9111-22. 902

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