ABC | Volume 112, Nº6, Junho 2019

Artigo Original Fonseca et al Desequilíbrio autonômico, sarcopenia e insuficiência cardíaca Arq Bras Cardiol. 2019; 112(6):739-746 1. von Haehling S, Ebner N, Dos Santos MR, Springer J, Anker SD. Muscle wasting and cachexia in heart failure: mechanisms and therapies. Nat Rev Cardiol. 2017;14(6):323-41. 2. Fulster S, TackeM, Sandek A, Ebner N, Tschope C, DoehnerW, et al. Muscle wasting in patients with chronic heart failure: results from the studies investigating co-morbidities aggravating heart failure (SICA-HF). Eur Heart J. 2013;34(7):512-9. 3. Dos Santos MR, Saitoh M, Ebner N, Valentova M, Konishi M, Ishida J, et al. Sarcopenia and Endothelial Function in PatientsWithChronicHeart Failure: Results From the Studies Investigating Comorbidities Aggravating Heart Failure (SICA-HF). J AmMed Dir Assoc. 2017;18(3):240-5. 4. Hajahmadi M, Shemshadi S, Khalilipur E, Amin A, Taghavi S, Maleki M, et al. Muscle wasting in young patients with dilated cardiomyopathy. 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Roberts HC, Denison HJ, Martin HJ, Patel HP, Syddall H, Cooper C, et al. A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach. Age Ageing. 2011;40(4):423-9. 20. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010;39(4):412-23. 21. Narumi T,Watanabe T, Kadowaki S, Takahashi T, YokoyamaM, Kinoshita D, et al.Sarcopeniaevaluatedbyfat-freemassindexisanimportantprognosticfactor in patients with chronic heart failure. Eur J InternMed. 2015;26(2):118-22. 22. Janssen SP, Gayan-Ramirez G, Van den Bergh A, Herijgers P, Maes K, Verbeken E, et al. Interleukin-6 causesmyocardial failure and skeletal muscle atrophy in rats. Circulation. 2005;111(8):996-1005. 23. Bechara LR, Moreira JB, Jannig PR, Voltarelli VA, Dourado PM, Vasconcelos AR, et al. NADPH oxidase hyperactivity induces plantaris atrophy in heart failure rats. Int J Cardiol. 2014;175(3):499-507. 24. Li YP, Chen Y, Li AS, Reid MB. Hydrogen peroxide stimulates ubiquitin- conjugating activity and expression of genes for specific E2 and E3 proteins in skeletal musclemyotubes. Am J Physiol Cell Physiol. 2003;285(4):C806-12. Referências Potencial conflito de interesses Declaro não haver conflito de interesses pertinentes. Fontes de financiamento O presente estudo foi financiado pela Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP; 2015/22814‑5). Fonseca GWP foi apoiado pelo Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; 148758/2016-9); Dos Santos MR pela FAPESP (2016/24306-0); Negrão CE pela FAPESP (2015/22814-5). Todas as fundações são de São Paulo, Brasil. Vinculação acadêmica Este artigo é parte de tese de Doutorado de Guilherme Wesley Peixoto da Fonseca, pela Universidade de São Paulo. Aprovação ética e consentimento informado Este estudo foi aprovado pelo Comitê de Ética DA CAPPesq sob o número de protocolo 0892/07. Todos os procedimentos envolvidos nesse estudo estão de acordo com a Declaração de Helsinki de 1975, atualizada em 2013. O consentimento informado foi obtido de todos os participantes incluídos no estudo. 745