ABC | Volume 112, Nº5, Maio 2019

Artigo Original Effting et al Efeitos do ER: coração e obesidade Arq Bras Cardiol. 2019; 112(5):545-552 Este é um artigo de acesso aberto distribuído sob os termos da licença de atribuição pelo Creative Commons 22 Carbone S, Mauro AG, Mezzaroma E, Kraskauskas D, Marchetti C, Buzzetti R, et al. A high-sugar and high-fat diet impairs cardiac systolic and diastolic function in mice. Int J Cardiol. 2015 Nov 1;198:66-9. 23. Zeng C, Zhong P, Zhao Y, Kanchana K, Zhang Y, Khan ZA, et al. Curcumin protects hearts from FFA-induced injury by activating Nrf2 and inactivating NF- κ B both in vitro and in vivo. J Mol Cell Cardiol. 2015 Feb;79:1-12. 24. Chen F, Chen D, Zhao X, Yang S, Li Z, Sanchis D, et al. Interleukin-6 deficiency facilitates myocardial dysfunction during high fat diet-induced obesity by promoting lipotoxicity and inflammation. BiochimBiophys Acta Mol Basis Dis. 2017;1863(12):3128-41. 25. Farias JM, Bom KF, TrommCB, Luciano TF, Marques SO, Tuon T, et al. Effect of physical training on the adipose tissue of diet-induced obesity mice: interaction between reactive oxygen species and lipolysis. Horm Metab Res. 2013;45(3):190-6. 26. Pinho RA, Sepa-Kishi DM, Bikopoulos G, Wu M V., Uthayakumar A, Mohasses A, et al. High-fat diet induces skeletal muscle oxidative stress in a fiber type-dependent manner in rats. Free Radic Biol Med. 2017 Sep;110:381-9. 27. Pieri BL, Souza DR, Luciano TF, Marques SO, Pauli JR, Silva AS, et al. Effects of physicalexerciseontheP38MAPK/REDD1/14-3-3pathwaysinthemyocardium of diet-induced obesity rats. HormMetab Res. 2014;46(9):621-7. 28. Farhangi MA, Nameni G, Hajiluian G, Mesgari-Abbasi M. Cardiac tissue oxidative stress and inflammation after vitamin D administrations in high fat- diet induced obese rats. BMC Cardiovasc Disord. 2017;17(1):161. 29. Chen X, Zhong Z, Xu Z, Chen L, Wang Y. 2’,7’-Dichlorodihydrofluorescein as a fluorescent probe for reactive oxygen species measurement: forty years of application and controversy. Free Radic Res. 2010;44(6):587-604. 30. Tuon T, Souza PS, Santos MF, Pereira FT, Pedroso GS, Luciano TF, et al. Physicaltrainingregulatesmitochondrialparametersandneuroinflammatory mechanisms in an experimental model of Parkinson’s disease. Oxid Med Cell Longev. 2015;2015:261809. 31. Souza PS, Gonçalves ED, Pedroso GS, Farias HR, Junqueira SC, Marcon R, et al. Physical exercise attenuates experimental autoimmune encephalomyelitis by inhibiting peripheral immune response and blood- brain barrier disruption. Mol Neurobiol. 2017;54(6):4723-37. 32. Yi Y, Wang L, Li G, Guo H. A review on research progress in the direct synthesis of hydrogen peroxide from hydrogen and oxygen: noble-metal catalytic method, fuel-cell method and plasma method. Catal Sci Technol. 2016;6(6):1593-1610. 33. Lennicke C, Rahn J, Lichtenfels R, Wessjohann LA, Seliger B. Hydrogen peroxide - production, fate and role in redox signaling of tumor cells. Cell Commun Signal. 2015 Sep 14;13:39. 34. Muthulakshmi S, Saravanan R. Protective effects of azelaic acid against high- fat diet-induced oxidative stress in liver, kidney and heart of C57BL/6J mice. Mol Cell Biochem. 2013;377(1-2):23-33. 35. Done AJ, Traustadóttir T. Nrf2mediates redox adaptations to exercise. Redox Biol. 2016 Dec;10:191-9. 36. MerryTL,RistowM.Nuclearfactorerythroid-derived2-like2 (NFE2L2,Nrf2) mediates exercise-induced mitochondrial biogenesis and the anti-oxidant response in mice. J Physiol. 2016;594(18):5195-207. 37. WilliamsonD, Gallagher P, HarberM, HollonC, Trappe S. Mitogen-activated protein kinase (MAPK) pathway activation: effects of age and acute exercise on human skeletal muscle. J Physiol. 2003;547(Pt 3):977-87. 38. JooMS, KimWD, Lee KY, Kim JH, Koo JH, KimSG. AMPK facilitates nuclear accumulation of Nrf2 by phosphorylating at serine 550. Mol Cell Biol. 2016;36(14):1931-42. 39. PetersenAMW, Pedersen BK. The anti-inflammatory effect of exercise. J Appl Physiol. 2005;98(4):1154-62. 40. Benatti FB, Pedersen BK. Exercise as an anti-inflammatory therapy for rheumatic diseases-myokine regulation. Nat Rev Rheumatol. 2015;11(2):86-97. 552