ABC | Volume 112, Nº2, Fevereiro 2019

Minieditorial Lima Exercício e modulação de MicroRNA do alho envolvidos na cardiopatia diabética Arq Bras Cardiol. 2019; 112(2):163-164 Alguns desses efeitos positivos obtidos pelo exercício físico e ingestão de alho podem ser modulados por microRNA específicos, de acordo com Mostafa e colaboradores. É interessante observar que a resposta a esses tratamentos foi amplificada quando combinados, quase como um efeito adjuvante. Apesar destes resultados promissores e interessantes, são necessários mais estudos sobre quais mecanismos e quais vias intracelulares modulam a expressão de microRNA envolvidos na angiogênese cardíaca e melhora do perfil lipídico proporcionado pelo exercício físico voluntário e consumo de alho no diabetes melito. 1. Rosa CM, Xavier NP, Campos DH, Fernandes AA, Cezar MD, Martinez PF, et al. Diabetes mellitus activates fetal gene program and intensifies cardiac remodeling and oxidative stress in aged spontaneously hypertensive rats. Cardiovasc Diabetol. 2013 Oct 17;12:152. 2. Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract. 2011;94(3):311-21. 3. Tag H, Kalita P, Dwivedi P, Das AK, Namsa ND. Herbal medicines used in the treatment of diabetes mellitus in Arunachal Himalaya, northeast, India. J Ethnopharmacol. 2012;141(3):786-95. 4. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993;75(5):843-54. 5. Baggish AL, Hale A, Weiner RB, Lewis GD, Systrom D, Wang F, et al. Dynamic regulation of circulating microRNA during acute exhaustive exercise and sustained aerobic exercise training. J Physiol. 2011;589(Pt 16):3983-94. 6. Guay C, Regazzi R. CirculatingmicroRNAs as novel biomarkers for diabetes mellitus. Nat Rev Endocrinol. 2013;9(9): 513-21. 7. Naderi R, Mohaddes G, Mohammadi M, Alihemmati A, Khamaneh A, Ghyasi R, Ghaznavi R. The Effect of Garlic and Voluntary Exercise onCardiac Angiogenesis in Diabetes: the role of MiR-126 and MiR-210. Arq Bras Cardiol. 2019; 112(2):154-162 8. Bayan L, Koulivand PH, Gorji A. Garlic: a review of potential therapeutic effects. Avicenna J Phytomed. 2014;4(1):1-14. 9. Naderi R, Mohaddes G, Mohammadi M, Alihemmati A, Badalzadeh R, Ghaznavi R, et al. Preventive effects of garlic (Allium sativum) on oxidative stressandhistopathologyofcardiactissue instreptozotocin-induceddiabetic rats. Acta Physiol Hung. 2015;102(4):380-90. 10. Huang KC, Wu WT, Yang FL, Chiu YH, Peng TC, Hsu BG, et al. Effects of freshwater clam extract supplementation on time to exhaustion, muscle damage, pro/anti-inflammatory cytokines, and liver injury in rats after exhaustive exercise. Molecules. 2013;18(4):3825-38. 11. Gomes MJ, Martinez PF, Campos DHS, Pagan LU, Bonomo C, Lima AR, et al. Beneficial effects of physical exercise on functional capacity and skeletal muscle oxidative stress in rats with aortic stenosis-induced heart failure. Oxid Med Cell Longev. 2016;2016:8695716. 12. Osipova J, Fischer DC, Dangwal S, Volkmann I, Widera C, Schwarz K, et al. Diabetes-associated microRNAs in pediatric patients with type 1 diabetes mellitus: a cross-sectional cohort study. J Clin Endocrinol Metab. 2014;99(9):E1661-5. 13. Fasanaro P, D’Alessandra Y, Di Stefano V, Melchionna R, Romani S, Pompilio G, et al. MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3. J Biol Chem. 2008;283(23):15878-83. 14. Huang CJ, Webb HE, Zourdos MC, Acevedo EO. Cardiovascular reactivity, stress, and physical activity. Front Physiol. 2013 Nov 7;4:314. 15. Shabani E, Sayemiri K, Mohammadpour M. The effect of garlic on lipid profile and glucose parameters in diabetic patients: A systematic review and meta-analysis. Prim Care Diabetes. 2018;S1751-9918(18)30200-6. Referências Este é um artigo de acesso aberto distribuído sob os termos da licença de atribuição pelo Creative Commons 164