ABC | Volume 110, Nº6, Junho 2018

Artigo Original Zhen et al CAA leva a HC óbvia usando agulha de 0,45 mm Arq Bras Cardiol. 2018; 110(6):568-576 Fontes de financiamento O presente estudo foi financiado pelo The National Natural Science Foundation of China (número 81570343). Vinculação acadêmica Este artigo é parte de tese de Doutorado de Zhen Jia pela Zhejiang University. Aprovação Ética e consentimento informado Este estudo foi aprovado pelo Comitê de Ética do First Affiliated Hospital, College of Medicine, Zhejiang University sob o número de protocolo 2014-17. Todos os procedimentos envolvidos nesse estudo estão de acordo com a Declaração de Helsinki de 1975, atualizada em 2013. O consentimento informado foi obtido de todos os participantes incluídos no estudo. 1. Zhao CZ, Zhao XM, Yang J, Mou Y, Chen B, Wu HD, et al. Inhibition of farnesyl pyrophosphate synthase improves pressure overload induced chronic cardiac remodeling. Sci Rep. 2016Dec 23;6:39186. doi: 10.1038/ srep39186. 2. Frey N, Olson EN. Cardiac hypertrophy: the good, the bad, and the ugly. Annu Rev Physiol. 2003;65:45-79. doi: 10.1146/annurev. physiol.65.092101.142243. 3. Alla F, Zannad F, Filippatos G. Epidemiology of acute heart failure syndromes. Heart Fail Rev. 2007;12(2):91-5. doi: 10.1007/s10741-007-9009-2. 4. Sato N, Lam CS, Teerlink JR, Greenberg BH, Tsutsui H, Oh BH, et al. Evaluating the efficacy, safety, and tolerability of serelaxin when added to standard therapy in Asian patients with acute heart failure: design and rationale of RELAX-AHF-ASIA trial. J Card Fail. 2017;23(1):63-71. doi: 10.1016/j.cardfail.2016.10.016. 5. YamamotoK,OhishiM,KatsuyaT, ItoN, IkushimaM,KaibeM,etal.Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin II. Hypertension. 2006;47(4):718-26. doi: 10.1161/01.HYP.0000205833.89478.5b. 6. Liao Y, Bin J, Asakura M, Xuan W, Chen B, Huang Q, et al. Deficiency of type 1 cannabinoid receptors worsens acute heart failure induced by pressure overload inmice. Eur Heart J. 2012;33(24):3124-33. doi: 10.1093/ eurheartj/ehr246. 7. Martinez-Rubio A, Schwammenthal Y, Schwammenthal E, Block M, Reinhardt L, Garcia-Alberola A, et al. Patients with valvular heart disease presenting with sustained ventricular tachyarrhythmias or syncope: results ofprogrammedventricularstimulationand long-term follow-up.Circulation. 1997;96(2):500-8. doi: https://doi.org/10.1161/01.CIR.96.2.500. 8. Massengill MT, Ashraf HM, Chowdhury RR, Chrzanowski SM, Kar J, Warren SA, et al. Acute heart failure with cardiomyocyte atrophy induced in adult mice by ablation of cardiac myosin light chain kinase. Cardiovasc Res. 2016;111(1):34-43. doi: 10.1093/cvr/cvw069. 9. Foppa M, Arora G, Gona P, Ashrafi A, Salton CJ, Yeon SB, et al. Right ventricular volumes and systolic function by cardiac magnetic resonance and the impact of sex, age, and obesity in a longitudinally followed cohort free of pulmonary and cardiovascular disease: the Framingham Heart Study. Circ Cardiovasc Imaging. 2016;9(3):e003810. doi: 10.1161/ CIRCIMAGING.115.003810. 10. Karimian S, Stein J, Bauer B, Teupe C. Impact of severe obesity and weight loss on systolic left ventricular function and morphology: assessment by 2-dimensional speckle-tracking echocardiography. J Obes. 2016;2016:2732613. doi: 10.1155/2016/2732613. 11. Elliott P, McKenna WJ. Hypertrophic cardiomyopathy. Lancet. 2004;363(9424):1881-91. doi: 10.1016/S0140-6736(04)16358-7. 12. Zhao B, Wang S, Chen J, Ji Y, Wang J, Tian X, et al. Echocardiographic characterization of hypertrophic cardiomyopathy in Chinese patients with myosin-binding protein C3 mutations. Exp Ther Med. 2017;13(3):995- 1002. doi: 10.3892/etm.2017.4089. 13. Hunter JJ, Chien KR. Signaling pathways for cardiac hypertrophy and failure. N Engl J Med. 1999;341(17):1276-83. doi: 10.1056/ NEJM199910213411706. 14. Huang CK, Chen BY, Guo A, Chen R, Zhu YQ, Kutschke W, et al. Sildenafil ameliorates left ventricular T-tubule remodeling in a pressure overload- inducedmurine heart failuremodel. Acta Pharmacol Sin. 2016;37(4):473- 82. doi: 10.1038/aps.2016.13. 15. Tsotetsi OJ, Woodiwiss AJ, Netjhardt M, Qubu D, Brooksbank R, Norton GR. Attenuation of cardiac failure, dilatation, damage, and detrimental interstitial remodeling without regression of hypertrophy in hypertensive rats. Hypertension. 2001;38(4):846-51. doi: https://doi.org/10.1161/ hy1001.092649. 16. KuwaharaF,KaiH,TokudaK,KaiM,TakeshitaA,EgashiraK,etal.Transforming growthfactor-betafunctionblockingpreventsmyocardialfibrosisanddiastolic dysfunction inpressure-overloadedrats.Circulation.2002;106(1):130-5.doi: https://doi.org/10.1161/01.CIR.0000020689.12472.E0. 17. Minior VK, Levine B, Ferber A, Guller S, Divon MY. Nucleated red blood cells as a marker of acute and chronic fetal hypoxia in a rat model. Rambam Maimonides Med J. 2017;8(2). doi: 10.5041/RMMJ.10302. Referências 575