ABC | Volume 110, Nº5, Maio 2018

Artigo Original Salmazo et al Frequência de aterosclerose subclínica em brasileiros infectados pelo HIV Arq Bras Cardiol. 2018; 110(5):402-410 1. Brasil. Ministério da Saúde. Vigilância, Prevenção eControle das IST, doHIC/ Aids e das Hepatites virais. Boletim Epidemiológico HIV/Aids-2013;2(1). Brasília; 2013. 2. Global report: UNAIDS report on the global AIDS epidemic 2013. Geneva: UNAIDS; 2013. 3. Maggi P, Perilli F, Lillo A, Gargiulo M, Ferraro S, Grisorio B, et al. Rapid progressionofcarotidlesionsinHAART-treatedHIV‑1patients.Atherosclerosis. 2007;192(2):407-12. doi: 10.1016/j.atherosclerosis.2006.05.026. 4. Bonilla H, Mcshannic J, Goldberg E, Chua D, Conner R, Fiorentino M, et al. Impact of human immunodeficiency virus infection on measures of cardiovascular disease in long-term nonprogressors. Infect Dis Clin Pract. 2013;21(3):177-80. doi: 10.1097/IPC.0b013e31828262f3. 5. Barbaro G. HIV infection, highly active antiretroviral therapy and the cardiovascular system. Cardiovasc Res. 2003;60(1):87-95. doi: https://doi. org/10.1016/S0008-6363(02)00828-3. 6. Hulten E, Mitchell J, Scally J, Gibbs B, Villines T. HIV positivity, protease inhibitor exposure and subclinical atherosclerosis: a systematic review and meta-analysis of observational studies. Heart. 2009;95(22):1826-35. doi: 10.1136/hrt.2009.177774. 7. Xavier HT, Izar MC, Faria Neto JR, Assad MH, Rocha VZ, Sposito AC, et al. [V BrazilianGuidelines on dyslipidemias and prevention of atherosclerosis]. ArqBras Cardiol. 2013;101(4 Suppl 1):1-20. doi: http://dx.doi.org/10.5935/ abc.2013S010. 8. Goodman A. Accelerated atherosclerosis in HIV-positive patients may be due to disease, not treatment. 50th Interscience Conference on Antimicrobial Agents andChemotherapy (ICAAC); 2010 Sept 12-15; Boston (Massachusetts). Abstract H-220. 9. ZamanAG,HelftG,WorthleySG,Badimon JJ.Theroleofplaqueruptureand thrombosis incoronaryarterydisease.Atherosclerosis.2000;149(2):251-66. doi: http://dx.doi.org/10.1016/S0021-9150(99)00479-7. 10. Kaplana R, Kingsley L, Ganged S, Benning L, Jacobson L, Lazar J, et al. LowCD4R T-cell count as amajor atherosclerosis risk factor inHIV‑infected women and men. AIDS. 2008;22(13):1615-24. doi: 10.1097/ QAD.0b013e328300581d. 11. da Silva EF, Fonseca FA, França CN, Ferreira PR, Izar MC, Salomão R, et al. Imbalance between endothelial progenitors cells andmicroparticles inHIV- infected patients naive for antiretroviral therapy. AIDS. 2011;25(13):1595- 601. doi: 10.1097/QAD.0b013e32834980f4. 12. Sposito AC, Caramelli B, Fonseca FA, Bertolami MC, Afiune Neto A, Souza AD, et al; Sociedade Brasileira de Cardiologia. [IV Brazilian Guideline for DyslipidemiaandAtherosclerosisprevention:DepartmentofAtherosclerosis of Brazilian Society of Cardiology]. Arq Bras Cardiol. 2007 Apr;88 Suppl 1:2-19. doi: http://dx.doi.org/10.1590/S0066-782X2007000700002. 13. Fox C, Evans J, Larson M, Kannel W, Levy D. Temporal trends in coronary heart disease mortality and sudden cardiac death from 1950 to 1999 - the Framinghamheart study. Circulation. 2004;110(5):522-7. doi: 10.1161/01. CIR.0000136993.34344.41. 14. Schambelan M, Wilson P, Yarasheski K, Cade WT, Dávila-Román V, D’Agostino RB Sr, et al. Development of appropriate coronary heart disease risk prediction models in HIV-infected patients. AHA conference proceedings. Circulation. 2008;118(2):e48-53. doi: 10.1161/ CIRCULATIONAHA.107.189627. 15. Hsue PY,Waters DD.What a cardiologist needs to know about patients with human immunodeficiency virus infection. Circulation. 2005;112(25):3947- 57. doi: 10.1161/CIRCULATIONAHA.105.546465. 16. HIV and Cardiovascular Disease: annual update. California: Annenberg Center for Health Sciences at Eisenhower, American Academy of HIV Medicine, Clinical Care Options-HIV; 2010. p. 1-23. 17. Goldberger Z, Valle J, Dandekar V, Chan P, Ko D, Nallamothu B, et al. Are changes in carotid intima-media thickness related to risk of nonfatal myocardial infarction? A critical review and meta-regression analysis. Am Heart J. 2010;160(4):701-14. doi: 10.1016/j.ahj.2010.06.029. 18. Grunfeld C, Delaney J, Wanke C, Currier J, Scherzer R, Biggs M, et al. Preclinical atherosclerosis due to HIV infection: carotid intima-medial thickness measurements from the FRAM study (Fat Redistribution and Metabolic Change in HIV Infection). AIDS. 2009;23(14):1841-9. doi: 10.1097/QAD.0b013e32832d3b85. 19. Hsue P, Lo J, Franklin A, Bolger A, Martin J, Deeks S. Progression of atherosclerosis as assessed by carotid intima-media thickness in patients with HIV infection. Circulation. 2004;109(13):1603-8. doi: 10.1161/01. CIR.0000124480.32233.8A. 20. Currier JS, Kendall MA, HenryWK, Alston-Smith B, Torriani FJ, Tebas P, et al. Progression of carotid artery intima-media thickening in HIV-infected and uninfected adults. ACTG 5078 Study Team. AIDS. 2007;21(9):1137-45. doi: 10.1097/QAD.0b013e32811ebf79. 21. Stein J, Korcarz C, Hurst R, Lonn E, Kendall C, Mohler E, et al; American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Useofcarotidultrasoundto identifysubclinicalvasculardiseaseandevaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography carotid intima-media thickness task force endorsed by the Society for Vascular Medicine. J Am Soc Echocardiogr. 2008;21(2):93-111. doi: 10.1016/j.echo.2007.11.011. 22. Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Bornstein N, et al. MannheimCarotid Intima-Media Thickness Consensus (2004–2006). An update on behalf of the Advisory Board of the 3rd and 4th Watching the Risk Symposium, 13th and 15th European Stroke Conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006. CerebrovascDis. 2007;23(1):75-80. doi: 10.1159/000097034. 23. Touboul PJ, Vicaut E, Labreuche J, Belliard J, Cohen S, Kownator S, et al; PARC study participating physicians. Correlation between the Framingham risk score and intima media thickness: the Paroi Artérielle et Risque Cardio-vasculaire (PARC) study. Atherosclerosis. 2007;192(2):363-9. doi: 10.1016/j.atherosclerosis.2006.05.017. 24. Nambi V, Chambless L, Folsom A, He M, Hu Y, Mosley T, et al. Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk: the ARIC (Atherosclerosis Risk In Communities)study. JAmCollCardiol.2010;55(15):1600-7.doi:10.1016/j. jacc.2009.11.075. 25. Ridker P, Cook N. Clinical usefulness of very high and very low levels of C-reactiveproteinacrossthefullrangeofFraminghamriskscores.Circulation. 2004;109(16):1955-9. doi: 10.1161/01.CIR.0000125690.80303.A8. Referências Trabalhos experimentais envolvendo seres humanos Este estudo foi aprovado pelo Comitê de Ética em Pesquisa da Faculdade de Medicina de Botucatu sob o número de protocolo CEP: 3451-2010. Todos os procedimentos envolvidos nesse estudo estão de acordo com a Declaração de Helsinki de 1975, atualizada em 2013. O consentimento informado foi obtido de todos os participantes incluídos no estudo. 409