ABC | Volume 110, Nº3, Março 2018

Artigo Original Lemos et al Exercício melhora as arteríolas esplênicas em SHR Arq Bras Cardiol. 2018; 110(3):263-269 Este um artigo de acesso aberto distribuído sob os termos da licen a de atribui ão pelo Creative Commons 5. Cuspidi C, Sala C, Zanchetti A. Metabolic syndrome and target organ damage: role of blood pressure. Expert Rev Cardiovasc Ther. 2008;6(5):731- 43. doi: 10.1586/14779072.6.5.731. 6. Kristensen BO. Aspects of immunology and immunogenetics in human essential hypertensionwith special reference to vascular events. J Hypertens. 1984;2(5):571-9. PMID: 6396331. 7. AcampaM,FranchiM,GuideriF,LambertiI,BruniF,PastorelliM,etal.Cardiac dysautonomia and arterial distensibility in essential hypertensives. Auton Neurosci. 2009;146(1-2):102-5. doi: 10.1016/j.autneu.2008.11.009. 8. Kramer JM, Beatty JA, Plowey ED, Waldrop TG. Exercise and hypertension: amodel for central neural plasticity. Clin Exp Pharmacol Physiol. 2002;29(1- 2):122-6. doi: 10.1046/j.1440-1681.2002.03610X. 9. GandoY,YamamotoK,MurakamiH,OhmoriY,KawakamiR,SanadaK,etal. Longer time spent in light physical activity is associatedwith reduced arterial stiffness in older adults. Hypertension. 2010:56(3):540-6. doi: 10.1161/ HYPERTENSIONAHA.110.156331. 10. Barbosa NetoO, AbateDT, Marocolo Júnior M, Mota GR, Orsatti FL, Rossi e Silva RC, et al. Exercise training improves cardiovascular autonomic activity and attenuates renal damage in spontaneously hypertensive rats. J Sports Sci Med. 2013;12(1):52-9. PMID: 24149725. 11. Higa-Taniguchi KT, Silva FC, Silva HM, Michelini LC, Stern JE. Exercise training-induced remodeling of paraventricular nucleus (nor)adrenergic innervation in normotensive and hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2007;292(4):R1717-27. doi: 10.1152/ ajpregu.00613.2006. 12. Gutkowska J, Aliou Y, Lavoie JL, Gaab K, Jankowski M, Broderick TL. Oxytocin decreases diurnal and nocturnal arterial blood pressure in the conscious unrestrained spontaneously hypertensive rat. Pathophysiology. 2016;(2):111-21. doi: 10.1016/j.pathophys.2016.03.003. 13. SeoTB,HanLS,YoonJH,HongKE,YoonSJ,NamgungUK.InvolvementofCdc2 in axonal regeneration enhanced by exercise training in rats. Med Sci Sports Exerc. 2006;38(7):1267-76. doi: 10.1249/01.mss.0000227311.00976.68. 14. Gobatto CA, de Mello MA, Sibuya CY, de Azevedo JR, dos Santos LA, Kokubun E. Maximal lactate steady state in rats submitted to swimming exercise. Comp Biochem Physiol A Mol Integr Physiol. 2001;130(1):21-7. PMID: 11672680. 15. Silva FC, Guidine PA, Ribeiro MF, Fernandes LG, Xavier CH, de Menezes RC, et al. Malnutrition alters the cardiovascular responses induced by central injection of tityustoxinin Fischer rats. Toxicon. 2013Dec 15;76:343-9. doi: 10.1016/j.toxicon.2013.09.015. 16. Goldberger JJ. Sympathovagal balance: how should we measure it? Am J Physiol. 1999;276(4 pt 2):H1273-80. PMID: 10199852. 17. Melo RM, Martinho E Jr, Michelini LC. Training-induced, pressure- lowering effect in SHR wide effects on circulatory profile of exercised and nonexercisedmuscles. Hypertension. 2003;42(4):851-7. doi: 10.1161/01. HYP.0000086201.27420.33. 18. Folkow B. Physiological aspects of primary hypertension. Physiol Rev. 1982;62(2):347-504. PMID: 6461865. 19. Levy BI, Ambrosio G, Pries AR, Struijker-Boudier HA. Microcirculation in hypertension: a new target for treatment? Circulation. 2001;104(6):735-40. doi: https://doi.org/10.1161/hc3101.091158. 20. Mulvany MJ. Small artery remodeling and significance in the development of hypertension. News Physiol Sci. 2002 Jun;17:105-9. doi: 10.1152/ nips.01366.2001. 21. AmaralSL,ZornTM,MicheliniLC.Exercisetrainingnormalizeswall-to-lumen ratio of the gracilis muscle arterioles and reduces pressure in spontaneously hypertensive rats. J Hypertens. 2000;18(11):1563-72. PMID: 11081768. 22. Pauletto P, Scannapieco G, Pessina AC. Sympathetic drive and vascular damage in hypertension and atherosclerosis. Hypertension. 1991;17(4 Suppl):III75-81. PMID: 2013498. 23. IntenganHD, Schiffrin EL. Structure andmechanical properties of resistance arteries in hypertension: role of adhesionmolecules and extracellular matrix determinants. Hypertension. 2000;36(3):312-8. PMID: 10988257. 24. Laurent S, Boutouyrie P, Lacolley P. Structural and genetic bases of arterial stiffness. Hypertension. 2005;45(6):1050-5. doi: 10.1161/01. HYP.0000164580.39991.3d. 25. Laurent S, Briet M, Boutouyrie P. Large and small artery cross-talk and recent morbidity-mortality trials in hypertension. Hypertension. 2009;54(2):388- 92. doi: 10.1161/HYPERTENSIONAHA.109.133116. 26. Yasmin, O’Shaughnessy KM. Genetics of arterial structure and function: towards new biomarkers for aortic stiffness? Clin Sci (Lond). 2008;114(11):661-77. doi: 10.1042/CS20070369. 27. Martinez-Lemus LA, Hill MA, Meininger GA. The plastic nature of the vascular wall: a continuum of remodeling events contributing to control of arteriolar diameter and structure. Physiology (Bethesda). 2009 Feb;24:45- 57. doi: 10.1152/physiol.00029.2008. 28. Cheng C, Daskalakis C, Falkner B. Alterations in capillary morphology are found inmild blood pressure elevation. J Hypertens. 2010;28(11):2258-66. doi: 10.1097/HJH.0b013e32833e113b. 29. CornelissenVA,FagardRH.Effectsofendurancetrainingonbloodpressure,blood pressure-regulatingmechanisms,andcardiovascularriskfactors.Hypertension. 2005;46(4):667-75. doi: 10.1161/01.HYP.0000184225.05629.51. 30. Zucker IH, Patel KP, SchultzHD, Li YF,WangW, Pliquett RU. Exercise training and sympathetic regulation in experimental heart failure. Exerc Sport Sci Rev. 2004;32(3):107-11. PMID: 15243206. Erratum in: Exerc Sport Sci Rev. 2004;32(4):191. 31. Iwasaki KI, Zhang R, Zuckerman JH, Levine BD. Dose-response relationship of the cardiovascular adaptation to endurance training in healthy adults: How much training for what benefit? J Appl Physiol (1985). 2003;95(4):1575-83. doi: 10.1152/japplphysiol.00482.2003. 32. Roveda F, Middlekauff HR, Rondon MU, Reis SF, Souza M, Nastari L, et al. The effects of exercise training on sympathetic neural activation in advanced heart failure: a randomized controlled trial. J Am Coll Cardiol. 2003;42(5):854-60.doi :https://doi.org/10.1016/S0735-1097( 03)00831-3. 33. Collins HL, Rodenbaugh DW, DiCarlo SE. Daily exercise attenuates the development of arterial blood pressure related cardiovascular risk factors in hypertensiverats.ClinExpHypertens.2000;22(2):193-202.PMID:10744359. 34. Kramer JM, Beatty JA, Plowey ED, Waldrop TG. Exercise and hypertension: amodel for central neural plasticity. Clin Exp Pharmacol Physiol. 2002;29(1- 2):122-6. doi: 10.1046/j.1440.1681.2002.036.10.X. 35. GandoY,YamamotoK,MurakamiH,OhmoriY,KawakamiR,SanadaK,etal. Longer time spent in light physical activity is associatedwith reduced arterial stiffness in older adults. Hypertension. 2010;56(3):540-6. doi: 10.1161/ HYPERTENSIONAHA.110.156331. 36. Thijssen DH, Maiorana AJ, O’Driscoll G, Cable NT, HopmanMT, Green DJ. Impact of inactivity and exercise on the vasculature in humans. Eur J Appl Physiol. 2010;108(5):845-75. doi: 10.1007/s00421-009-1260-x. 37. Abate DT, Barbosa Neto O, Rossi e Silva RC, Faleiros AC, Correa RR, da Silva VJ, et al. Exercise-training reduced blood pressure and improve placental vascularization inpregnantspontaneouslyhypertensiverats–pilotstudy.Fetal Pediatr Pathol. 2012;31(6):423-31. doi: 10.3109/15513815.2012.659535. 38. Meredith IT, Jennings GL, Esler MD, Dewar EM, Bruce AM, Fazio VA. Time- course of the antihypertensive and autonomic effects of regular endurance exercise inhumansubjects.JHypertens.1990;8(9):859-66.PMID:2172376. 39. Negrão CE, Irigoyen MC, Moreira ED, Brum PC, Freire PM, Krieger EM. Effect of exercise training on RSNA, baroreflex control and blood pressure responsiveness. Am J Physiol. 1993;265(2 Pt 2):R365-70. PMID: 8368390. 40. Gava NS, V ras-Silva AS, Negrão CE, Krieger EM. Low-intensity exercise training attenuates cardiac beta-adrenergic tone during exercise in spontaneously hypertensive rats. Hypertension. 1995;26(6 Pt 2):1129-33. doi: https:doi.org/10.1161/01.HYP.26.6.1129. 269