ABC | Volume 110, Nº3, Março 2018

Artigo Original Rodrigues et al Treinamento aeróbico em camundongos β 1ARKO Arq Bras Cardiol. 2018; 110(3):256-262 Este um artigo de acesso aberto distribuído sob os termos da licen a de atribui ão pelo Creative Commons 26. KemiOJ,LoennechenJP,WisloffU,EllingsenO. Intensity-controlledtreadmill running in mice: cardiac and skeletal muscle hypertrophy. J Appl Physiol (1985). 2002;93(4):1301-9. doi: 10.1152/japplphysiol.00231.2002. 27. Moore RL, Korzick DH. Cellular adaptations of the myocardium to chronic exercise. Prog Cardiovasc Dis. 1995;37(6):371-96. PMID: 7777668. 28. Chruscinski AJ, Rohrer DK, Schauble E, Desai KH, Bernstein D, Kobilka BK. Targeted disruption of the beta2 adrenergic receptor gene. J Biol Chem. 1999;274(24):16694-700. PMID: 10358008. 29. RohrerDK,ChruscinskiA,SchaubleEH,BernsteinD,KobilkaBK.Cardiovascular and metabolic alterations in mice lacking both beta1- and beta2-adrenergic receptors. J Biol Chem. 1999;274(24):16701-8. PMID: 10358009. 30. Boyda HN, Procyshyn RM, Pang CC, Barr AM. Peripheral adrenoceptors: the impetus behind glucose dysregulation and insulin resistance. J Neuroendocrinol. 2013;25(3):217-28. doi: 10.1111/jne.12002. 31. Bristow MR, Ginsburg R, Umans V, Fowler M, Minobe W, Rasmussen R, et al. Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes tomusclecontractionandselectivebeta1-receptordown-regulation inheart failure. Circ Res. 1986;59(3):297-309. PMID: 2876788. 32. Zhu WZ, Zheng M, Koch WJ, Lefkowitz RJ, Kobilka BK, Xiao RP. Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adultmousecardiacmyocytes.ProcNatlAcadSciUSA.2001;98(4):1607‑12. doi: 10.1073/pnas.98.4.1607. 33. Rohrer DK, Desai KH, Jasper JR, Stevens ME, Regula DP Jr, Barsh GS, et al. Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects. Proc Natl Acad Sci U S A. 1996;93(14):7375-80. PMID: 8693001. 34. Zhu WZ, Chakir K, Zhang S, Yang D, Lavoie C, Bouvier M, et al. Heterodimerization of beta1- and beta2-adrenergic receptor subtypes optimizes beta-adrenergic modulation of cardiac contractility. Circ Res. 2005;97(3):244-51. doi: 10.1161/01.RES.0000176764.38934.86 35. ZhouYY,YangD,ZhuWZ,ZhangSJ,WangDJ,RohrerDK,etal.Spontaneous activation of beta(2)- but not beta(1)-adrenoceptors expressed in cardiac myocytes from beta(1)beta(2) double knockout mice. Mol Pharmacol. 2000;58(5):887-94. PMID: 11040034. 36. O’Connell TD, Jensen BC, Baker AJ, Simpson PC. Cardiac alpha1-adrenergic receptors: novel aspects of expression, signaling mechanisms, physiologic function, and clinical importance. Pharmacol Rev. 2014;66(1):308-33. doi: 10.1124/pr.112.007203. 37. Korzick DH, Hunter JC, McDowell MK, DelpMD, Tickerhoof MM, Carson LD. Chronic exercise improves myocardial inotropic reserve capacity through alpha1-adrenergic and protein kinase C-dependent effects in Senescent rats. J Gerontol A Biol Sci Med Sci. 2004;59(11):1089-98. PMID: 15602054. 38. Korzick DH, Moore RL. Chronic exercise enhances cardiac alpha 1-adrenergic inotropic responsiveness in rats with mild hypertension. Am J Physiol. 1996;271(6 Pt 2):H2599-608. PMID: 8997321. 39. Beaulieu M, Brakier-Gingras L, Bouvier M. Upregulation of alpha1A- and alpha1B-adrenergic receptor mRNAs in the heart of cardiomyopathic hamsters. J Mol Cell Cardiol. 1997;29(1):111-9. doi: 10.1006/ jmcc.1996.0256. 40. Milligan G, Svoboda P, Brown CM. Why are there so many adrenoceptor subtypes? Biochem Pharmacol. 1994;48(6):1059-71. PMID: 7945399. 41. Kemi OJ, HaramPM, Loennechen JP, Osnes JB, Skomedal T, Wisloff U, et al. Moderate vs. high exercise intensity: differential effects on aerobic fitness, cardiomyocyte contractility, and endothelial function. Cardiovasc Res. 2005;67(1):161-72. doi: 10.1016/j.cardiores.2005.03.010. 42. Kemi OJ, Ellingsen O, Ceci M, Grimaldi S, Smith GL, Condorelli G, et al. Aerobic interval training enhances cardiomyocyte contractility and Ca2+ cycling by phosphorylation of CaMKII and Thr-17 of phospholamban. J Mol Cell Cardiol. 2007 Sep;43(3):354-61. doi: 10.1016/j.yjmcc.2007.06.013. 43. Kemi OJ, Ceci M, Condorelli G, Smith GL, Wisloff U. Myocardial sarcoplasmic reticulum Ca2+ ATPase function is increased by aerobic interval training. Eur J Cardiovasc Prev Rehabil. 2008 Apr;15(2):145-8. doi: 10.1097/HJR.0b013e3282efd4e0. 262

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