ABC | Volume 110, Nº1, Janeiro 2018

Artigo Original Hu et al Modulação da melatonina no cálcio nos cardiomiócitos Arq Bras Cardiol. 2018; 110(1):44-51 1. HausenloyDJ,YellonDM.Myocardialischemia-reperfusioninjury:aneglected therapeutictarget.JClinInvest.2013;123(1):92-100.doi:10.1172/JCI62874. 2. Morel O, Perret T, Delarche N, Labeque JN, Jouve B, Elbaz M, et al. Pharmacological approaches to reperfusion therapy. Cardiovasc Res. 2012;94(2):246-52. doi: 10.1093/cvr/cvs114. 3. Ibanez B, Heusch G, Ovize M, Van de Werf F. Evolving therapies for myocardial ischemia/reperfusion injury. J Am Coll Cardiol. 2015;65(14):1454-71. doi: 10.1016/j.jacc.2015.02.032. 4. Chen M, Zheng YY, Song YT, Xue JY, Liang ZY, Yan XX, et al. Pretreatment with low-dosegadoliniumchlorideattenuatesmyocardialischemia/reperfusioninjury inrats.ActaPharmacolSin.2016;37(4):453-62.doi:10.1038/aps.2015.156. 5. Bulluck H, Yellon DM, Hausenloy DJ. Reducing myocardial infarct size: challenges and future opportunities. Heart. 2016;102(5):341-8. doi: 10.1136/heartjnl-2015-307855. 6. Fauconnier J, Roberge S, Saint N, Lacampagne A. Type 2 ryanodine receptor: a novel therapeutic target in myocardial ischemia/reperfusion. Pharmacol Ther. 2013;138(3):323-32. doi: 10.1016/j.pharmthera.2013.01.015. 7. Hardeland R, Pandi-Perumal SR, Cardinali DP. Melatonin. Int J BiochemCell Biol. 2006;38(3):313-6. doi: 10.1016/j.biocel.2005.08.020. 8. Sun H, Gusdon AM, Qu S. Effects of melatonin on cardiovascular diseases: progress in the past year. Curr Opin Lipidol. 2016;27(4):408-13. doi: 10.1097/MOL.0000000000000314. 9. Yang Y, Sun Y, YiW, Li Y, Fan C, Xin Z, et al. A reviewof melatonin as a suitable antioxidant against myocardial ischemia-reperfusion injury and clinical heart diseases. J Pineal Res. 2014;57(4):357-66. doi: 10.1111/jpi.12175. 10. Yu L, Liang H, Dong X, Zhao G, Jin Z, Zhai M, et al. Reduced silent information regulator 1 signaling exacerbates myocardial ischemia- reperfusion injury in type 2 diabetic rats and the protective effect of melatonin. J Pineal Res 2015;59(3):376-90. doi: 10.1111/jpi.12269. 11. Yu L, Liang H, Lu Z, Zhao G, Zhai M, Yang Y, et al. Membrane receptor- dependent Notch1/Hes1 activation by melatonin protects against myocardial ischemia-reperfusion injury: in vivo and in vitro studies. J Pineal Res 2015;59(4):420-33. doi: 10.1111/jpi.12272. 12. Sahna E, Parlakpinar H, Turkoz Y, Acet A. Protective effects of melatonin on myocardial ischemia/reperfusion induced infarct size and oxidative changes. Physiol Res. 2005;54(5):491-5. PMID: 15641932. 13. PetrosilloG,ColantuonoG,MoroN,RuggieroFM,TiravantiE,DiVenosaN,et al. Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening. Am J Physiol Heart Circ Physiol 2009;297(4):H1487-93. doi: 10.1152/ajpheart.00163.2009. 14. Tan DX, Manchester LC, Reiter RJ, Qi W, Kim SJ, El-Sokkary GH. Ischemia/ reperfusion-induced arrhythmias in the isolated rat heart: prevention by melatonin. J Pineal Res. 1998;25(3):184-91. PMID: 9745988. 15. Galano A, Tan DX, Reiter RJ. On the free radical scavenging activities of melatonin’s metabolites, AFMK and AMK. J Pineal Res. 2013;54(3):245-57. doi: 10.1111/jpi.12010. 16. Galano A, Tan DX, Reiter RJ. Melatonin as a natural ally against oxidative stress: a physicochemical examination. J Pineal Res. 2011;51(1):1-16. doi: 10.1111/j.1600-079X.2011.00916.x. 17. SahnaE,DenizE,Bay-KarabulutA,BurmaO.Melatoninprotectsmyocardiumfrom ischemia-reperfusioninjuryinhypertensiverats:roleofmyeloperoxidaseactivity. ClinExpHypertens.2008;30(7):673-81.doi:10.1080/10641960802251966. 18. Yang Y, Duan W, Jin Z, Yi W, Yan J, Zhang S, et al. JAK2/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury. J Pineal Res. 2013;55(3):275-86. doi: 10.1111/jpi.12070. 19. YeungHM,HungMW,FungML.Melatoninamelioratescalciumhomeostasis in myocardial and ischemia-reperfusion injury in chronically hypoxic rats. J Pineal Res. 2008;45(4):373-82. doi: 10.1111/j.1600-079X.2008.00601.x. 20. Kho C, Lee A, Jeong D, Oh JG, Gorski PA, Fish K, et al. Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure. Nat Commun. 2015 Jun 12;6:7229. doi: 10.1038/ncomms8229. 21. PaillardM, Tubbs E, Thiebaut PA, Gomez L, Fauconnier J, Da Silva CC, et al. Depressing mitochondria-reticulum interactions protects cardiomyocytes from lethal hypoxia-reoxygenation injury. Circulation. 2013;128(14):1555- 65. doi: 10.1161/CIRCULATIONAHA.113.001225. 22. Signore S, Sorrentino A, Ferreira-Martins J, Kannappan R, Shafaie M, Del Ben F, et al. Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytes. Circulation. 2013;128(12):1286-97. doi: 10.1161/ CIRCULATIONAHA.113.002764. 23. Hayashi T, Su TP. Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival. Cell. 2007;131(3):596- 610. doi: 10.1016/j.cell.2007.08.036. 24. Hausenloy DJ, Yellon DM. New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway. Cardiovasc Res. 2004;61(3):448-60. doi: 10.1016/j. cardiores.2003.09.024. 25. Skyschally A, Gent S, Amanakis G, Schulte C, Kleinbongard P, Heusch G. Across-species transfer of protection by remote ischemic preconditioning with species-specific myocardial signal transduction by reperfusion injury salvage kinase and survival activating factor enhancement pathways. Circ Res 2015;117(3):279-88. doi: 10.1161/CIRCRESAHA.117.306878. 26. Patino P, Parada E, Farre-Alins V, Molz S, Cacabelos R, Marco-Contelles J, et al. Melatonin protects against oxygen and glucose deprivation by decreasing extracellular glutamate and Nox-derived ROS in rat hippocampal slices. Neurotoxicology. 2016 Dec;57:61-8. doi: 10.1016/j.neuro.2016.09.002. 27. Piper HM, Garcia-Dorado D, Ovize M. A fresh look at reperfusion injury. Cardiovasc Res. 1998;38(2):291-300. PMID: 9709390. 28. Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med. 2007;357(11):1121-35. doi: 10.1056/NEJMra071667. 29. Ravassa S, Zudaire A, Diez J. GLP-1 and cardioprotection: from bench to bedside. Cardiovasc Res. 2012;94(2):316-23. doi: 10.1093/cvr/cvs123. 30. BorgersM,ThoneF,VanReempts J,VerheyenF.Theroleofcalcium incellular dysfunction. Am J Emerg Med. 1983;1(2):154-61. PMID: 6680615. 31. RizzutoR,MarchiS,BonoraM,AguiariP,BononiA,DeStefaniD,etal.Ca(2+) transfer from the ER tomitochondria: when, how and why. BiochimBiophys Acta. 2009;1787(11):1342-51. doi: 10.1016/j.bbabio.2009.03.015. 32. Bers DM. Cardiac excitation-contraction coupling . Nature. 2002;415(6868):198-205. doi: 10.1038/415198a. 33. Domenech RJ, Sanchez G, Donoso P, Parra V, Macho P. Effect of tachycardia on myocardial sarcoplasmic reticulum and Ca2+dynamics: a mechanism for preconditioning? J Mol Cell Cardiol. 2003;35(12):1429-37. PMID: 14654369. 34. Gomez L, Thiebaut PA, Paillard M, Ducreux S, Abrial M, Crola Da Silva C, et al. The SR/ER-mitochondria calcium crosstalk is regulated by GSK3beta during reperfusion injury. Cell Death Differ. 2016;23(2):313-22. doi: 10.1038/cdd.2015.101. Erratum in: Cell Death Differ. 2015;22(11):1890. 35. Younce CW, Burmeister MA, Ayala JE. Exendin-4 attenuates high glucose-induced cardiomyocyte apoptosis via inhibition of endoplasmic reticulum stress and activation of SERCA2a. Am J Physiol Cell Physiol. 2013;304(6):C508-18. doi: 10.1152/ajpcell.00248.2012. 36. Sahach VF, Rudyk OV, Vavilova HL, Kotsiuruba AV, Tkachenko IuP. [Melatonin recovers ischemic tolerance and decreases the sensitivity of mitochondrial permeability transition pore opening in the heart of aging rats]. Fiziol Zh 2006;52(3):3-14. PMID: 16909751. 37. Giacomo CG, Antonio M. Melatonin in cardiac ischemia/reperfusion- inducedmitochondrial adaptive changes. CardiovascHematol DisordDrug Targets. 2007;7(3):163-9. PMID: 17896956. Referências Este é um artigo de acesso aberto distribuído sob os termos da licença de atribuição pelo Creative Commons 51