ABC | Volume 115, Nº2, August 2020

Original Article Mattos BP et al. Sudden death in hypertrophic cardiomyopathy Arq Bras Cardiol. 2020; 115(2):197-204 Table 2 – Cardiovascular outcomes in 90 patients with hypertrophic cardiomyopathy patients during a 6±3-year follow-up Heart failure class III/IV 20 (22%) Atrial fibrillation (n, %) 29 (32%) Alcohol septal ablation (n, %) 9 (10%) Surgical myectomy (n, %) 3 (3%) Dual-chamber pacemaker (n, %) 6 (7%) ICD implantation (n, %) 15 (17%) Appropriate ICD shock (n, %) 2 (2%) Sudden cardiac death (n, %) 6 (7%) HCM non-related death (n, %) 6 (7%) ICD: implantable cardioverter defibrillator; HC:= hypertrophic cardiomyopathy. Table 3 – Distribution of sudden cardiac death predictors in the three risk categories of the 2014 European Society of Cardiology guideline ESC HCM Risk-SCD score p <4% ≥4%-<6 ≥6% (n=67;75%) (n=11;12%) (n=12;13%) Age (years) 64±11 60±17 57±13 0.156 Family history of SCD 14(21%) 4(36%) 5(42%) 0.177 Syncope 6(9%) 3(27%) 7(58%) 0.0001 MLVWT ≥30 mm 0 0 1 0.264 NSVT 3(4%) 6(54%) 8(67%) 0.0001 Abnormal BP response to exercise 8(12%) 0 1(8%) 0.595 LGE on CMR 8(12%) 1(9%) 2(17%) 0.822 LVOT ≥30 mmHg 31(46%) 7 (64%) 6(50%) 0.649 Left atrial diameter (mm) 46±7 48±9 48±8 0.545 MLVWT (mm) 17±3 21±2 21±8 0.002 Maximal LVOT gradient (mmHg) 33±42 45±39 40±44 0.77 SCD: sudden cardiac death, MLVWT: maximal left ventricular wall thickness; NSVT: non-sustained ventricular tachycardia; BP: blood pressure; LGE: late gadolinium enhancement; CMR; cardiac magnetic resonance; LVOT: left ventricular outflow tract. Table 4 – Contribution of sudden cardiac death risk predictors for the ESC HCM Risk-SCD score calculation Low risk Intermediate risk High risk <4% ≥4% - <6% ≥ 6% Median p25 - p75 Median p25 - p75 Median p25 - p75 ESC HCM Risk-SCD 1.88% 1.42-2.67 5.17% 4.89-5.70 7.82% 7.06-9.19 MLVWT 1.60% 1.25-2.02 3.20% 3.18-3.36 4.46% 4.07-5.09 Left atrial diameter 0.97% 0.83-1.21 1.86% 1.67-2.40 2.48% 2.21-3.51 LVOT gradient 0.03% 0.01-0.24 0.34% 0.15-0.61 0.35% 0.02-1.00 Family history of SCD 0.00% 0.00-0.00 0.00% 0.00-0.70 0.00% 0.00-0.99 NSVT 0.00% 0.00-0.00 1.14% 0.00-1.30 1.64% 0.00-1.96 Syncope 0.00% 0.00-0.00 0.00% 0.00-1.09 1.41% 0.00-1.59 Age -0.91% 0.8 - 1.13 -1.90% 1.12-2.03 -2.34% 1.49-2.73 ESC: European Society of Cardiology; MLVWT: maximal left ventricular wall thickness; LVOT: left ventricular outflow tract; SCD: sudden cardiac death; NSVT: non-sustained ventricular tachycardia. 200