ABC | Volume 115, Nº2, August 2020

Original Article Jesus et al. Meta-analysis: body adiposity and apolipoproteins Arq Bras Cardiol. 2020; 115(2):163-171 Quality of Evidence Evidence from 4 studies with 7,974 individuals followed for 12 to 144 months was included in the meta-analysis, enough time for the phenomenon to occur. Despite the limitations, this meta-analysis was well designed, based on the use of appropriate tools to assess the risk of bias, analyzing methodological quality and conducting statistical analyses that allowed investigating possible sources of heterogeneity. Conclusion Our findings suggest that excess body adiposity influences the reduction of ApoA1 values and increase in levels of ApoB in children and adolescents, these changes being even more relevant among adolescents. However, considering the low number of longitudinal studies found in this meta-analysis, we suggest further prospective studies that can identify the influence of body adiposity on these important markers of cardiovascular risk in adolescents, considering their negative effects throughout life. Author Contributions Conception and design of the research and Critical revision of the manuscript for intellectual content: Jesus GS, Costa PRF, Oliveira LPM, Queiroz VAO, Cunha CM, Pereira EM, Oliveira, AM; Acquisition of data: Jesus GS, Oliveira LPM, Queiroz VAO, Cunha CM, Pereira EM, Oliveira, AM; Analysis and interpretation of the data: Jesus GS, Costa PRF, Pereira EM, Oliveira, AM; Statistical analysis: Jesus GS, Costa PRF, Oliveira, AM; Obtaining financing: Jesus GS; Writing of the manuscript: Jesus GS, Costa PRF, Oliveira LPM, Queiroz VAO, Cunha CM, Oliveira, AM. Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. 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