ABC | Volume 115, Nº2, August 2020

Original Article Abellán-Huerta et al. Velocity-time integral of aortic regurgitation Arq Bras Cardiol. 2020; 115(2):253-260 Table 2 – Values of echocardiographic parameters Parameter Total (n=62) Moderate AR (n=40) Severe AR (n=22) p-value AR VTI (m) 2.1±0.5 2.2±0.5 1.9±0.5 0.010 AR VTIi (VTI/heart rate) 0.033±0.012 0.036±0.013 0.028±0.01 0.024 Aortic PHT (ms) 397.3±110.1 434.2±127 367.5±86.2 0.062 Vena contracta (mm) 6±1.5 5.5±1.5 7.1±1.2 0.035 ERO (cm 2 ) 0.31±0.2 0.18±0.1 0.44±0.1 0.002 Regurgitant volume (mL) 56.9±24 42.5±10.9 71.3±25.7 0.05 Thoracic aorta flow reversal 33 (53.2) 12 (30.8) 21 (95.5) <0.001 IV septum thickness (mm) 13.1±3.6 12.5±3.5 13.8±3.5 0.460 Posterior wall thickness (mm) 10.6±2.8 10.3±2.7 11±3.1 0.383 LVEDD (mm) 50.5±9 47.3±9.6 56.1±7.1 0.001 LVESD (mm) 31±11.4 26.9±12.3 38.4±8.1 <0.001 LVEDV (mL) 131.9±54.3 106±46.6 171±36.5 <0.001 LVESV (mL) 53.6±36.1 39.9±32.2 78.7±27.5 <0.001 LVEF (%) 59.7±13.2 63.2±13.3 54.1±11.2 0.012 AR peak velocity (m/s) 4.2±0.51 4.3±0.5 4.1±0.52 0.344 Aortic systolic peak velocity (m/s) 2.7±1.2 2.8±1.4 2.7±0.9 0.791 Bicuspid aortic valve 5 (8.1) 3 (4.8) 2 (3.2) 0.826 Elevated LV filling pressure 26 (41.9) 16 (42.1) 10 (50) 0.566 Severe mitral regurgitation 2 (3.2) 2 (5) 0 (0) 0.286 Severe mitral stenosis 1 (1.6) 1 (2.5) 0 (0) 0.455 Severe aortic stenosis 8 (12.9) 6 (15) 2 (9.1) 0.507 AR: aortic regurgitation; ERO: effective regurgitant orifice; IV: interventricular; LV: left ventricle; LVEF: left ventricular ejection fraction; LVEDD: left ventricular end- diastolic diameter; LVEDV: left ventricular end-diastolic volume; LVESD: left ventricular end-systolic diameter LVESV: left ventricular end-systolic volume; PHT: pressure half-time; VTI: velocity-time integral; VTIi; velocity-time integral index. Continuous variables with normal distribution are expressed as mean±standard deviation and categorical variables as n (percentage). Table 3 – Bivariate logistic regression model (dependent variable: severe aortic regurgitation) Odds ratio 95%CI p-value AR VTI 0.198 0.053–0.748 0.017 AR VTIi <0.001 <0.001–0.005 0.033 LVEF 0.941 0.895–0.989 0.017 LVEDD 1.144 1.047–1.249 0.003 LVESD 1.119 1.044–1.199 0.001 LVEDV 1.032 1.015–1.049 <0.001 LVESV 1.034 1.013–1.057 0.002 95%CI: 95% confidence interval; AR VTI: velocity-time integral of aortic regurgitation; AR VTIi: velocity-time integral index of aortic regurgitation; LVEDD: left ventricular end-diastolic diameter; LVEDV: left ventricular end-diastolic volume; LVEF: left ventricular ejection fraction; LVESD: left ventricular end-systolic diameter; LVESV: left ventricular end-systolic volume. Table 4 – Multivariate logistic regression model (dependent variable: severe aortic regurgitation) Odds ratio 95%CI p-value AR VTI 0.160 0.030–0.856 0.032 LVEF 1.005 0.933–1.082 0.895 LVEDD 1.049 0.934–1.178 0.419 LVEDV 1.030 1.009–1.052 0.005 Odds ratio 95%CI p-value AR VTIi <0.001 <0.001–<0.001 0.019 LVEF 1.007 0.932–1.089 0.859 LVEDD 1.063 0.939–1.204 0.333 LVEDV 1.032 1.010–1.055 0.005 95%CI: 95% confidence interval; AR VTI: velocity-time integral of aortic regurgitation; AR VTIi: velocity-time integral index of aortic regurgitation; LVEDD: left ventricular end-diastolic diameter; LVEDV: left ventricular end- diastolic volume; LVEF: left ventricular ejection fraction. 256