ABC | Volume 115, Nº2, August 2020

Original Article Gatti et al. Custodiol®-HTK solution & prolonged cross-clamp time Arq Bras Cardiol. 2020; 115(2):241-250 Table 1 – Baseline characteristics of patients and risk profiles*,† Characteristic Overall series PS-matched pairs HTK cohort n=38 MCB cohort n=110 p-Value Standardized difference HTK cohort n=34 MCB cohort n=34 p-Value Standardized difference Age (years) 66±9.5 66.3±9 0.850 66.1±10 65.3±9.6 0.740 70–80 12 (31.6) 40 (36.4) 0.001 12 (35.3) 12 (35.3) 0.027 >80 2 (5.3) 5 (4.5) 0.018 2 (5.9) 1 (2.9) 0.010 Female sex 4 (10.5) 11 (10) 1.000 0.057 2 (5.9) 1 (2.9) 1.000 0.001 Hypertension 32 (84.2) 85 (77.3) 0.489 0.007 28 (82.4) 24 (70.6) 0.252 0.000 Body mass index, kg/m 2 28 ± 5.1 27.6 ± 3.7 0.582 28.2±5.1 27.2±3.1 0.318 >30 10 (26.3) 26 (23.6) 0.008 9 (26.5) 9 (26.5) 0.001 Anaemia‡ 18 (47.4) 43 (39.1) 0.371 0.010 16 (47.1) 18 (52.9) 0.624 0.000 Diabetes on insulin 5 (13.1) 7 (6.4) 0.298 0.007 3 (8.8) 5 (14.7) 0.709 0.003 Chronic lung disease 4 (10.5) 8 (7.3) 0.731 0.018 3 (8.8) 3 (8.8) 1.000 0.005 eGFR, ml/min§ 75.1±39 83.5±28.4 0.156 74.9±40.9 78.6±26.7 0.659 50–85 12 (31.6) 44 (40) 0.032 10 (29.4) 13 (38.2) 0.001 ≤50 10 (26.3) 11 (10) 0.018 9 (26.5) 6 (17.6) 0.003 Chronic dialysis 2 (5.3) 2 (1.8) 0.573 0.131 2 (5.9) 1 (2.9) 1.000 0.014 Extracardiac arteriopathy 13 (34.2) 27 (24.5) 0.247 0.015 12 (35.3) 10 (29.4) 0.603 0.001 NYHA class IV 2 (5.3) 4 (3.6) 1.000 0.092 2 (5.9) 3 (8.8) 1.000 0.012 CCS class 4 24 (63.2) 52 (47.3) 0.091 0.026 20 (58.8) 18 (52.9) 0.624 0.002 Recent myocardial infarction 7 (18.4) 21 (19.1) 0.920 0.034 6 (17.6) 5 (14.7) 0.740 0.006 Coronary artery disease 0.423 0.606 Two-vessel 1 (2.6) 9 (8.2) 0.084 1 (2.9) 3 (8.8) 0.004 Three-vessel 37 (97.4) 101 (91.8) 0.008 33 (97.1) 31 (91.2) 0.000 Left main disease 10 (26.3) 43 (39.1) 0.156 0.042 10 (29.4) 10 (29.4) 1.000 0.006 LV ejection fraction, % 52.2±13 54.9 ± 10.1 0.205 52±12.7 52.1±11.4 0.960 31–50 13 (34.2) 30 (27.3) 0.012 11 (32.4) 13 (38.2) 0.001 <31 2 (5.3) 4 (3.6) 0.060 2 (5.9) 2 (5.9) 0.008 Use of IABP 5 (13.1) 11 (10) 0.762 0.016 3 (8.8) 2 (5.9) 1.000 0.003 Surgical priority 0.275 0.858 Elective 8 (21.1) 37 (33.6) 0.024 8 (23.5) 10 (29.4) 0.006 Urgent 29 (76.3) 72 (65.5) 0.031 25 (73.5) 23 (67.6) 0.003 Emergency 1 (2.6) 1 (0.9) - 1 (2.9) 1 (2.9) - Expected operative risk 3.5 (1.6−6.2) 1.7 (1.1−3.9) 0.005 3.3 (1.5−5.8) 3 (1.4−4.8) 0.812 (EuroSCORE II), %|| *Continuous variables were expressed as mean ± SD, or median and the range between the first and the third quartile. Categorical variables were expressed as frequencies and percentages. †Unless otherwise stated, the definitions and cut-off values of the preoperative variables were those used for EuroSCORE II. ‡Defined as haemoglobin <13 g/dl for men and <12 g/dl for women. §The creatinine clearance rate, calculated according to the Cockcroft-Gault formula, was used for approximating the GFR. ||Ref. 13. CCS: Canadian Cardiovascular Society; eGFR: estimated glomerular filtration rate; EuroSCORE: European System for Cardiac Operative Risk Evaluation; HYK: histidine-tryptophan-ketoglutarate; IABP: intra-aortic balloon pump; LV: left ventricular; MCB: multidose cold blood; NYHA: New York Heart Association; PS: propensity score; SD: standard deviation. 244