ABC | Volume 115, Nº1, July 2020

Original Article Pessoa et al. Cost-effectiveness comparison between drug-eluting stents and bare-metal stents Arq Bras Cardiol. 2020; 115(1):80-89 A similar distribution was observed for the 2 groups, except for more frequent unstable angina in the BMS group (46.5% vs 30.9%; p = 0.027). In the DES group, 31.0% of patients had diabetes, against 27.7% in the BMS group (p = 0.59), without statistically significant difference between the groups (Table 1). Regarding angiographic variables, the rate of type C lesions was 25.4% in the DES group and 19.9% in the BMS group, with no between-group difference. In both groups, there was a slight predominance of short lesions (<20 mm): 59.5% in the DES group and 54.6% in the BMS group (p = 0.49). Vessels with a diameter of <3.0 mm were more frequent in the DES group (47.3% vs 34.0%; p = 0.058) (Tables 2 and 3) . The 2 groups did not differ in the occurrence of thrombosis, infarction, stroke, angina, or death. The BMS group had more cases of ISR (10.1% vs 1.4%; p = 0.018) and, consequently, more cases of TLR (7.3% vs. 1.4%; p = 0.058) (Table 4). Figure 2 shows the Kaplan-Meier restenosis-free survival curve during follow-up (in days), stratified by stent type (DES × BMS) and compared by the log-rank test. Restenosis-free survival was significantly higher in the DES group than in the MBS group (p = 0.019). Table 1 - Clinical variables and comorbidities of the study groups Clinical variables DES BMS p-value Mean age (years) ± SD 61.8 ± 10.7 61.9 ± 9.7 0.98 * Male sex n (%) 44 59.5 94 66.7 0.30 White color n (%) 50 73.5 90 67.2 0.35 Comorbidities n (%) Hypertension 58 78.4 115 81.6 0.58 Diabetes mellitus 23 31 39 27.7 0.59 Obesity 18 25.0 31 22.6 0.92 Dyslipidemia 43 58.9 75 54.0 0.49 Smoking 13 17.8 29 21.2 0.17 Family history 50 68.5 77 56.6 0.094 Previous AMI 9 12.3 19 13.6 0.80 CRF 3 4.1 4 2.9 0.46 Hemodialysis 1 1.4 1 0.7 0.58 EF <40% 6 9.0 11 8.5 0.91 Silent ischemia 1 1.4 3 2.2 0.56 Stable angina 23 32.4 46 33.8 0.84 Unstable angina 33 46.5 43 30.9 0.027 NSTEMI 5 6.9 19 14.0 0.13 STEMI 12 16.4 31 22.6 0.29 Categorical data were expressed as frequency (n) and percentage (%) and compared by the X 2 test or Fisher's exact test. Numerical data with normal distribution were expressed as mean ± standard deviation and compared by Student's t test * for independent samples. Legend: DDES - drug-eluting stent; BMS - bare-metal stent; SD - standard deviation; EF - ejection fraction; AMI - acute myocardial infarction; CRF - chronic renal failure; STEMI: ST-segment elevation myocardial infarction; NSTEMI: non-ST-segment elevation myocardial infarction.Source: The Author, 2018. 83