ABC | Volume 115, Nº1, July 2020

Original Article Silva-Bertani et al. Mechanism of decreased heart collagen I in obesity Arq Bras Cardiol. 2020; 115(1):61-70 25. Santos PP Dos, Rafacho BPM, Gonçalves A de F, Jaldin RG, Nascimento TB do, Silva MAB, et al. Vitamin D induces increased systolic arterial pressure via vascular reactivity and mechanical properties. PLoS One. 2014;9(6):e98895. 26. Tyagi SC, Matsubara L, Weber KT. Direct extraction and estimation of collagenase(s) activity by zymography inmicroquantities of rat myocardium and uterus. Clin Biochem. 1993;26(3):191–8. 27. Nascimento AF, Luvizotto RAM, Leopoldo AS, Lima-Leopoldo AP, Seiva FR, Justulin LA, et al. Long-term high-fat diet-induced obesity decreases the cardiac leptin receptor without apparent lipotoxicity. Life Sci. 2011;88(23– 24):1031–8. 28. Lima-Leopoldo AP, Leopoldo AS, Sugizaki MM, Bruno A, Nascimento AF, Luvizotto RAM, et al. Disfunçãomiocárdica e alterações no trânsito de cálcio intracelular em ratos obesos. Arq Bras Cardiol. 2011;97(3):232–40. 29. Carroll JF, ZenebeWJ, Strange TB. Cardiovascular function in a rat model of diet-induced obesity. Hypertens (Dallas, Tex 1979). 2006;48(1):65–72. 30. Jéquier E. Pathways to obesity. Int J Obes Relat MetabDisord. 2002;26 Suppl 2:S12-7. 31. Nivoit P, Morens C, Van Assche FA, Jansen E, Poston L, Remacle C, et al. Establisheddiet-inducedobesity infemalerats leadstooffspringhyperphagia, adiposity and insulin resistance. Diabetologia. 2009;52(6):1133–42. 32. Relling DP, Esberg LB, Fang CX, Johnson WT, Murphy EJ, Carlson EC, et al. High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis. J Hypertens. 2006;24(3):549–61. 33. Omar B, Pacini G, Ahrén B. Differential development of glucose intolerance and pancreatic islet adaptation in multiple diet induced obesity models. Nutrients. 2012;4(10):1367–81. 34. Leopoldo AS, Lima-Leopoldo AP, Sugizaki MM, do Nascimento AF, de Campos DHS, Luvizotto R de AM, et al. Involvement of L-type calcium channel and SERCA2a in myocardial dysfunction induced by obesity. J Cell Physiol. 2011;226(11):2934–42. 35. Ferron AJT, Jacobsen BB, Sant’Ana PG, de Campos DHS, de Tomasi LC, Luvizotto R de AM, et al. Cardiac Dysfunction Induced by Obesity Is Not Related to β -Adrenergic System Impairment at the Receptor-Signalling Pathway. PLoS One. 2015;10(9):e0138605. 36. Yang R, Barouch LA. Leptin signaling and obesity: cardiovascular consequences. Circ Res. 2007;101(6):545–59. 37. Srinivasan SR, BaoW, WattigneyWA, Berenson GS. Adolescent overweight is associated with adult overweight and related multiple cardiovascular risk factors: the Bogalusa Heart Study. Metabolism. 1996;45(2):235–40. 38. Fitzgerald SM, Henegar JR, BrandsMW, Henegar LK, Hall JE. Cardiovascular and renal responses to a high-fat diet in Osborne-Mendel rats. Am J Physiol Regul Integr Comp Physiol. 2001;281(2):R547-52. 39. Martínez-Martínez E, Jurado-López R, Valero-Muñoz M, Bartolomé MV, Ballesteros S, Luaces M, et al. Leptin induces cardiac fibrosis through galectin-3, mTOR and oxidative stress: potential role in obesity. J Hypertens. 2014;32(5):1104–14; discussion 1114. 40. Hori Y, Kashimoto T, Yonezawa T, Sano N, Saitoh R, Igarashi S, et al. Matrix metalloproteinase-2 stimulates collagen-I expression through phosphorylation of focal adhesion kinase in rat cardiac fibroblasts. Am J Physiol Cell Physiol. 2012;303(9):C947-53. 41. Laviades C, Varo N, Fernández J, Mayor G, Gil MJ, Monreal I, et al. Abnormalities of the extracellular degradation of colágeno tipo I in essential hypertension. Circulation. 1998;98(6):535–40. 69

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