ABC | Volume 115, Nº1, July 2020

Original Article Silva-Bertani et al. Mechanism of decreased heart collagen I in obesity Arq Bras Cardiol. 2020; 115(1):61-70 DCT, Vileigas DF, De Tomasi LC, Campos DHS, Deus AF, Freire PP, Alves CAB; Analysis and interpretation of the data: Silva- Bertani DCT, Vileigas DF, Mota GAF, Souza SLB, De Tomasi LC, Campos DHS, Deus AF, Freire PP, Alves CAB, Cicogna AC; Statistical analysis: Silva-Bertani DCT, Padovani CR, Cicogna AC; Obtaining financing: Silva-Bertani DCT, Cicogna AC; Writing of the manuscript: Silva-Bertani DCT, Vileigas DF, Mota GAF, Souza SLB, Cicogna AC; Critical revision of the manuscript for intellectual content: Silva-Bertani DCT, Vileigas DF, Mota GAF, Souza SLB, Cicogna AC. Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. Sources of Funding This study was funded by FAPESP (2010/14208-4 and 2011/12165-9). Study Association This article is part of the thesis of master submitted by Danielle Cristina Tomaz da Silva-Bertani, from Faculdade de Medicina de Botucatu (UNESP). Ethics approval and consent to participate This study was approved by the Ethics Committee of the Faculdade deMedicina de Botucatu under the protocol number 861-2011. All the procedures in this study were in accordance with the 1975 Helsinki Declaration, updated in 2013. 1. World Health Organization.(WHO). Fact sheets: Obesity and overweight (Internet). (Cited 2018 Jan 18). Available from: https://www.who.int/news- room/fact-sheets/detail/obesity-and-overweight. 2. Bhurosy T, Jeewon R. Overweight and obesity epidemic in developing countries: a problem with diet, physical activity, or socioeconomic status? Scient World J. 2014;2014:964236. 3. Hall ME, Harmancey R, Stec DE. Lean heart: Role of leptin in cardiac hypertrophy and metabolism. World J Cardiol. 2015;7(9):511–24. 4. Segura AM, Frazier OH, Buja LM. 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