ABC | Volume 115, Nº1, July 2020

Original Article Silva-Bertani et al. Mechanism of decreased heart collagen I in obesity Arq Bras Cardiol. 2020; 115(1):61-70 have shown that high-fat diet-induced obesity leads to dyslipidemia, 19,34,35 whether due to changes in triacylglycerol, LDL, or HDL, in agreement with our study, which observed decreased serum HDL levels. Leptin is a hormone produced by adipose tissue, which participates in energy balance, by regulating food intake and the oxidation of lipids, 36 and in the biology of collagens. 5,14-16 Concerning the effects of obesity on the cardiovascular system, obesity did not promote left ventricular cardiac remodeling. However, SBP increased in obese animals. As SBP control involves the neurohumoral system, such as the sympathetic nervous system and the renin-angiotensin- aldosterone system, which are increased in obesity, 37 it may be inferred that the neurohumoral system is activated in Figure 1 – Metabolic and hormonal profile. (A) Fasting glucose, (B) Area under curve (AUC) of intraperitoneal glucose tolerance test, (C) insulin, (D) homeostasis model assessment of insulin resistance (HOMA-IR), (E) triacylglycerol, (F) total cholesterol, (G) high-density lipoprotein (HDL), (H) low-density lipoprotein (LDL) and (I) leptin in control and obese rats. (n= 15 – 21 per group). Data are presented as mean ± SD; Student’s t-test. *: p < 0.05. 65