ABC | Volume 115, Nº1, July 2020

Original Article Oliveira-Junior et al Effects of losartan in obesity Arq Bras Cardiol. 2020; 115(1):17-28 24. Müller-Fielitz H, Landolt J, Heidbreder M, Werth S, Vogt FM, Jöhren O, et al. Improved insulin sensitivity after long-term treatment with AT1 blockers is not associated with PPAR γ target gene regulation. Endocrinology. 2012;153(1):1103–15. 25. Silva DCT, Lima-Leopoldo AP, Leopoldo AS, Campos DHS, Nascimento AF, Oliveira Junior SA, et al. Influence of term of exposure to high-fat diet- induced obesity on myocardial collagen type I and III. Arq Bras Cardiol. 2014; 102(2):157-63. 26. Pfeffer JM, Pfeffer MA, Frohlich ED. Validity of an indirect tail-cuff method for determining systolic arterial pressure in unanesthetized normotensive and spontaneously hypertensive rats. J Lab Clin Med. 1971;78(6):957-8. 27. Martinez PF, Okoshi K, Zornoff LAM, Oliveira Jr SA, Campos DHS, Lima ARR, et al. Echocardiographic detection of congestive heart failure in postinfarction rats. J Appl Physiol. 2011;111(2):543-51. 28. Sahn DJ, De Maria A, Kisslo J, Weyman A. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements. Circulation. 1978;58(6):1072–83. 29. Cezar MDM, Damatto RL, Pagan LU, Lima ARR, Martinez PF, Bonomo C, et al. Early spironolactone treatment attenuates heart failure development by improving myocardial function and reducing fibrosis in spontaneously hypertensive rats. Cell Physiol Biochem 2015;36(4):1453-66. 30. Prabhu SD, Azimi A, Frosto T. Nitric oxide effects on myocardial function and force-interval relations: regulation of twitch duration. J Mol Cell Cardiol. 1999;31(12):2077-85. 31. David JS, Vivien B, Lecarpentier Y, Coriat P, Riou B. Interaction of protamine with α - and β -adrenoceptor stimulations in rat myocardium. Anesthesiology. 2001;95(5):1226-33. 32. Nascimento TB, Baptista RF, Pereira PC, Campos DH, Leopoldo AS, Lima- Leopoldo AP, et al. Vascular alterations in high-fat diet-obese rats: role of endothelial L-arginine/NO pathway. Arq Bras Cardiol. 2011;97(1):40-5. 33. Okoshi K, Ribeiro HB, Okoshi MP, Matsubara BB, Gonçalves G, Barros R, et al. Improved systolic ventricular functionwith normal myocardial mechanics in compensated cardiac hypertrophy. Jpn Heart J. 2004;45(4):647–56. 34. Oliveira-Junior SA, Martinez PF, FanWYC, Nakatani BT, Pagan LU, Padovani CR, et al. Association between echocardiographic structural parameters and body weight in Wistar rats. Oncotarget. 2017;8(16):26100-5. 35. Ren J, Walsh MF, Jefferson L, Natavio M, Lig KJ, Sowers JR, et al. Basal and ethanol-induced cardiac contractile response in lean and obese Zucker rat hearts. J Biomed Sci. 2000;7(5):390-400. 36. Furukawa H, Mawatari K, Koyama K, Yasui S, Morizumi R, Shimohata T, et al. Telmisartan increases localization of glucose transporter 4 to the plasma membrane and increases glucose uptake via peroxisome proliferator- activated receptor γ in 3T3-L1 adipocytes. Eur J Pharmacol. 2011;660(2- 3):485-91. 37. Thorwald M, Rodriguez R, Lee A, Martinez B, Peti-Peterdi J, Nakano D, et al. Angiotensin receptor blockade improves cardiac mitochondrial activity in response to an acute glucose load in obese insulin resistant rats. Redox Biol. 2018;14:371-8. 27