ABC | Volume 115, Nº1, July 2020

Original Article Oliveira-Junior et al Effects of losartan in obesity Arq Bras Cardiol. 2020; 115(1):17-28 1. Azevedo PS, Minicucci MF, Zornoff LAM. Obesity: a growing multifaceted problem. Arq Bras Cardiol. 2015;105(5):448-9. 2. Nunes CNM, Minicucci MF, Farah E, Fusco D, Azevedo PS, Paiva SAR, et al. Impact of different obesity assessment methods after acute coronary syndromes. Arq Bras Cardiol. 2014;103(1):19-24. 3. Gonçalves N, Silva AF, Rodrigues PG, Correia E, Moura C, Eloy C, et al. Early cardiacchanges inducedbyahypercaloricWestern-typediet in“subclinical” obesity. Am J Physiol Heart Circ Physiol. 2016;310(6):H655–66. 4. Alpert MA, Karthikeyan K, Abdullah O, Ghadban R. Obesity and Cardiac remodeling in adults: mechanisms and clinical implications. Prog Cardiovasc Dis. 2018;61(2):114-23. 5. de Cleva R, Araujo VA, Buchalla CCO, de Oliveira Costa F, Cardoso AF, Pajecki D, et al. Cardiac remodeling patterns in severe obesity according to arterial hypertension grade. Obes Surg. 2018;28(4):1047-54. 6. Oliveira-Junior SA, Dal Pai M, Guizoni DM, Torres BP, Martinez PF, Campos DHS, et al. Effects of AT1 receptor antagonism on interstitial and ultrastructural remodeling of heart in response to a hypercaloric diet. Physiol Rep. 2019;7(1):e13964. 7. Lima-Leopoldo AP, Leopoldo AS, Sugizaki MM, Bruno A, Nascimento AF, Luvizotto RA, et al. Myocardial dysfunction and abnormalities in intracellular calcium handling in obese rats. Arq Bras Cardiol. 2011;97(3):232–40. 8. Oliveira Junior SA, Padovani CR, Rodrigues SA, Silva NR, Martinez PF, Campos DHS, et al. Extensive impact of saturated fatty acids on metabolic and cardiovascular profile in rats with diet-induced obesity: a canonical analysis. Cardiovasc Diabetol. 2013;12(1):65. 9. Martins F, Campos DHS, Pagan LU, Martinez PF, Okoshi K, Okoshi MP, et al. Dieta hiperlipídica promove remodelação cardíaca em modelo experimental de obesidade. Arq Bras Cardiol. 2015;105(5):479-86. 10. Oliveira Junior SA, Dal Pai-Silva M, Martinez PF, Campos DHS, Lima- Leopoldo AP, et al. Differential nutritional, endocrine, and cardiovascular effects in obesity-prone and obesity-resistant rats fed standard and hypercaloric diets. Med Sci Monit. 2010;16(7):BR208–217a. 11. Oliveira-Junior SA, Martinez PF, Guizoni DM, Campos DHS, Fernandes T, Oliveira EM, et al. AT1 receptor blockade attenuates insulin resistance and myocardial remodeling in rats with diet-induced obesity. Plos One. 2014;9(1): e86447. 12. Lima-Leopoldo AP, Leopoldo AS, Silva DCT, Nascimento AF, Campos DHS, Luvizotto RAM, et al. Influence of long-term obesity on myocardial gene expression. Arq Bras Cardiol. 2013;100(3):229-37. 13. Lima-Leopoldo AP, Leopoldo AS, da Silva DC, do Nascimento AF, de Campos DH, Luvizotto RA, et al. Long-termobesity promotes alterations in diastolic function induced by reduction of phospholamban phosphorylation at serine-16 without affecting calcium handling. J Appl Physiol (1985). 2014;117(6):669-78. 14. da Silva VL, Lima-Leopoldo AP, Ferron AJT, Cordeiro JP, Freire PP, de Campos DHS, et al. Moderate exercise training does not prevent the reduction in myocardial L-type Ca2+ channels protein expression at obese rats. Physiol Rep. 2017;5(19):e13466. 15. Jacobsen BB, Leopoldo APL, Cordeiro JP, Campos DHS, Nascimento AFD, Sugizaki MM, et al. Cardiac, metabolic and molecular profiles of sedentary rats in the initial moment of obesity. Arq Bras Cardiol. 2017;109(5):432-9. 16. Vileigas DF, de Deus AF, da Silva DCT, Tomasi LC, Campos DHS, Adorni CS, et al. Saturated high-fat diet-induced obesity increases adenylate cyclase of myocardial b-adrenergic systemand does not compromise cardiac function. Physiol Rep. 2016;4(17):e12914. 17. Leopoldo AS, Lima-Leopoldo AP, Sugizaki MM, do Nascimento AF, de Campos DH, Luvizotto Rde A, et al. Involvement of L-type calcium channel and SERCA2a in myocardial dysfunction induced by obesity. J Cell Physiol. 2011:226(11):2934-42. 18. Ferron AJT, Jacobsen BB, Sant’Ana PG, Campos DHS, Tomasi LC, Luvizotto RAM, et al. Cardiac dysfunction induced by obesity is not related to β -adrenergic system impairment at the receptor-signaling pathway. Plos One. 2015;10(9):e0138605. 19. Campos DH, Leopoldo AS, Lima-Leopoldo AP, Nascimento AF, Oliveira- Junior SA, Silva DC, et al. Obesity preserves myocardial function during blockade of the glycolytic pathway. Arq Bras Cardiol. 2014;103(4):330-7. 20. Schütten MT, Houben AJ, de Leeuw PW, Stehouwer CD. The link between adipose tissue renin-angiotensin-aldosterone system signaling and obesity- associated hypertension. Physiology (Bethesda). 2017;32(3):197-209. 21. du Toit EF, NabbenM, Lochner A. A potential role for angiotensin II in obesity induced cardiac hypertrophy and ischaemic/reperfusion injury. Basic Res Cardiol. 2005;100(4):346-54. 22. Yoshida T, Tabony AM, Galvez S, Mitch WE, Higashi Y, Sukhanov S, et al. Molecular mechanisms and signaling pathways of angiotensin II induced muscle wasting: potential therapeutic targets for cardiac cachexia. Int J Biochem Cell Biol. 2013;45(10):2322-32. 23. RamalingamL, Menikdiwela K, LeMieuxM, Dufour JM, Kaur G, Kalupahana N, et al. The renin angiotensin system, oxidative stress and mitochondrial function in obesity and insulin resistance. Biochim Biophys Acta Mol Basis Dis. 2017;1863(5):1106-14. References Author contributions Conception and design of the research: Oliveira-Junior SA, Okoshi MP, Martinez PF; Acquisition of data: Muzili NA, Carvalho MR, Ota GE, Morais CS, Vieira LFC, Ortiz MO, Campos DHS, Cezar MDM, Okoshi K; Analysis and interpretation of the data: Oliveira-Junior SA, Campos DHS, Cezar MDM, Okoshi MP, Okoshi K, Cicogna AC, Martinez PF; Statistical analysis and writing of the manuscript: Oliveira- Junior SA; Obtaining financing: Oliveira-Junior SA, Martinez PF; Critical revision of the manuscript for intellectual content: Okoshi MP, Okoshi K, Cicogna AC, Martinez PF. Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. Sources of Funding This study was funded by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) - Financial code 001, Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq - process nº 422776/2016-5), and Federal University of Mato Grosso do Sul (UFMS). Study Association This article is related to the thesis of master submitted by Nayara de Araújo Muzili, from Universidade Federal de Mato Grosso do Sul. Ethics approval and consent to participate This study was approved by the Ethics Committee of the UNESP under the protocol number 1000/2013. All the procedures in this study were in accordance with the 1975 Helsinki Declaration, updated in 2013. 26