ABC | Volume 115, Nº1, July 2020

Original Article Oliveira-Junior et al Effects of losartan in obesity Arq Bras Cardiol. 2020; 115(1):17-28 However, isolated effects of dietary variables as a cause of cardiac remodeling cannot be ruled out, although these effects have been improved with AT 1 antagonism. In a previous study, 8 increased lipid consumption was shown to be directly related to characteristics of cardiovascular response in obesity. Therefore, this is an important study limitation and new investigations should be developed to better clarify the isolated role of saturated and unsaturated fatty acids in this experimental model. Conclusion In conclusion, high-fat diet-induced obesity promotes cardiac remodeling, sustained by ventricular hypertrophy and myocardial dysfunction. Considering that Losartan attenuated most of these disorders, the initial hypotheses of this investigation was confirmed, according to which the AT 1 receptor stimulation is associated with impaired myocardial function in obese rats. Figure 4 – Functional assessment of the isolated papillary muscle, according to Isoproterenol concentration. Results expressed regarding the baseline with extracellular [Ca 2+ ] equal to 1.0 mM value (mean±SD); (A) DT: maximum developed tension; (B) +dT/dt: maximum positive DT change; (C) -dT/dt: maximum DT decrease; CO: Control group; OB: Obese group; CL: Control Losartan group; OL: Obese group under Losartan. Group’s effect: * p<0.05 compared to C; ‡ p<0.05 compared to CL. Isoproterenol’s Effect: §, p<0.05 compared to Baseline; ¶, p<0.05 vs 0.1 mM; Two-Way RMANOVA and Bonferroni Test. 25