ABC | Volume 115, Nº1, July 2020

Original Article Oliveira-Junior et al Effects of losartan in obesity Arq Bras Cardiol. 2020; 115(1):17-28 reduced preload could cause lower ejection, 11,33 which was not confirmed by the results. Likewise, increased systolic performance is associated with ventricular hypertrophy and/or changes in afterload in OB. The afterload is a mechanical variable directly influenced by changes in pressure and intraventricular diameter and inversely related to ventricular wall thickness. 33,34 However, the papillary function assessment showed that obesity per se was not associated with basal changes, not only in response to various [Ca 2+ ] but also isoproterenol concentrations. A previous study showed decreased contractile strength and other functional disorders in basal conditions of obese papillary muscles. 35 Lima-Leopoldo et al. 7 showed that increased Ca 2+ extracellular concentration resulted in lower values of myocardial parameters of contraction (DT) and relaxation (-dT/dt) in obesity. These divergencesmay regarddifferences in dietary compositions, including added sugar 7 and/or lipid profile from formulations. Figure 1 – Functional papillary muscle assessment at baseline with extracellular [Ca 2+ ] equal to 2.5 mM; results in mean±SD; (A) DT: maximum developed tension; (B) +dT/dt: maximum DT variation speed; (C) –dT/dt: maximum DT decrease; CO: Control group; OB: Obese group; CL: Control Losartan group; OL: Obese Losartan group. * p<0.05 compared to CO; Two-Way ANOVA and Tukey Test. 22