ABC | Volume 115, Nº1, July 2020

Original Article Derakhshanian et al. Quercetin improves glucocorticoid-induced dyslipidemia Arq Bras Cardiol. 2020; 115(1):102-108 Author contributions Conception and design of the research: Derakhshanian H, Djalali M, Djazayery A, JavanbakhtMH, Dehpour AR; Acquisition of data: Derakhshanian H, Zarei M, Eslamian G; Analysis and interpretation of the data: Derakhshanian H, Javanbakht MH, Zarei M, Eslamian G, Mirhashemi SS; Statistical analysis: Derakhshanian H, Mirhashemi SS, Mirhashemi SS, Mirhashemi SS, Mirhashemi SS, Mirhashemi SS, Mirhashemi SS; Obtaining financing: Derakhshanian H, Djalali M, Djazayery A; Writing of the manuscript: Derakhshanian H; Critical revision of the manuscript for intellectual content: Derakhshanian H, Djalali M, Djazayery A, Javanbakht MH, Hekmatdoost A, Dehpour AR. Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. Sources of Funding This study was funded by Tehran University of Medical Sciences. Study Association This article is part of the thesis of Master submitted by Hoda Derakhshanian, from Tehran University of Medical Sciences. Ethics approval and consent to participate This study was approved by the Ethics Committee of the Tehran University of Medical Sciences under the protocol number 11157. All the procedures in this study were in accordance with the 1975 Helsinki Declaration, updated in 2013. Figure 3 – Mean of apolipoprotein B to apolipoprotein Al ratio in the different groups. Data presented as Mean±SE. n=8 for all groups. MP: methylprednisolone; Q50: quercetin 50 mg/kg; Q150: quercetin 150 mg/kg; ApoB/Al: apolipoprotein B to apolipoprotein Al ratio; * p<0.05 compared with control group, † p<0.05 compared with MP group, ‡ p<0.05 compared with MP+Q50. 2.00 1.50 1.00 .50 .00 2.50 Control MP MP+Q50 MP+Q150 Group Error bars: +/– 2 SD Apo B/A1 *‡ † † 1. Arafah BM. Pharmacology of glucocorticoids. In: Levine A, editor. Adrenal disorders. Contemporary endocrinology. Cham: Humana Press; 2018. p. 67-81. 2. Moghadam-Kia S, Werth VP. Prevention and treatment of systemic glucocorticoid side effects. Int J Dermatol. 2010;49(3):239-48. 3. Staels B, van Tol A, Chan L, Verhoeven G, Auwerx J. Variable effects of different corticosteroids on plasma lipids, apolipoproteins, and hepatic apolipoproteinmRNA levels in rats. Arterioscler Thromb. 1991;11(3):760-9. 4. Yadav A, Jahan A, Yadav TP, Sachdev N, Chitkara A, Asare R. Effect of glucocorticoids on serum lipid profile and endothelial function and arterial wall mechanics. Indian J Pediatr. 2013;80(12):1007-14. 5. Bentz AB. A Review of quercetin: chemistry, antioxident properties, and bioavailability. J Young Investig. 2009 apr. 6. Shah PM, Priya VV, Gayathri R. Quercetin-a flavonoid: a systematic review. J Pharm Sci Res. 2016;8(8):878-80. References 106