ABC | Volume 114, Nº6, June 2020

Original Article Yurre et al. Evaluation of the cardiac effects of WSMoL Arq Bras Cardiol. 2020; 114(6):1029-1037 Figure 3 – Left ventricular function and structure were preserved after WSMoL treatment. The results obtained by ECHO from both groups are summarized in the following: (A) ventricular ejection fraction, (B) fractional area change, (C) stroke volume, (D) final diastolic and (E) final systolic volume, and (F) left ventricular mass (CNTRL n = 7 mice and WSMoL n = 10 mice). Comparisons between groups were performed using unpaired Student’s t test. Each dot represents individual values and lines represent mean values. ○: CNTRL mice; ●: WSMoL mice. The results are shown as mean ± SD. 80 A B C D E F 60 40 20 0 80 60 40 20 0 80 60 40 20 0 120 80 40 0 50 40 20 30 10 0 40 20 30 10 0 CNTRL FE (%) Stroke volume (µl) Systolic volume (µl) LV mass (µl) Distolic volume (µl) FAC (%) WsMoL CNTRL WsMoL CNTRL WsMoL CNTRL WsMoL CNTRL WsMoL CNTRL WsMoL action potential recordings in intact hearts. Finally, the authors thank Professor Antonio Galina from Federal University of Rio de Janeiro for his support in the mitochondrial experiments. Author contributions Conception and design of the research and obtaining financing: Paiva PMG, Medei E; Acquisition of data: Rodriguez de Yurre A, da Silva JDF, Torres MK, Martins EL, Ramos IP, Silva WSFL, Sarpa JS, Guedes CCS; Analysis and interpretation of the data and statistical analysis: Rodriguez de Yurre A, d a Silva JDF, Martins EL, Ramos IP; Writing of the manuscript and critical revision of the manuscript for intellectual content: Rodriguez de Yurre A, da Silva JDF, Napoleão TH, Paiva PMG, Coelho LCBB, Medei E. Rodriguez de Yurre A and da Silva JDF contriuted equaly to this work. Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. Sources of Funding This study was funded by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior and Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco. Study Association This study is associated with postgraduate program in Biological sciences and physiology of UFRJ and postgraduate program in Biochemistry and physiology of UFPE. Ethics approval and consent to participate This study was approved by the Ethics Committee of the Universidade Federal do Rio de Janeiro under the protocol number DFBCICB041. All the procedures in this study were in accordance with the 1975 Helsinki Declaration, updated in 2013. 1034