ABC | Volume 114, Nº4, Suplement, April 2020

Case Report Adar et al. Dabigatran and massive pleuropericardial effusion Arq Bras Cardiol 2020; 114(4Suppl.1):13-15 Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. Sources of Funding There were no external funding sources for this study. Study Association This study is not associatedwith any thesis or dissertationwork. Ethics approval and consent to participate This article does not contain any studies with human participants or animals performed by any of the authors. 1. Eikelboom JW, Wallentin L, Connolly SJ, Ezekowitz M, Healey JS, Oldgren J et al. Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: an analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trial. Circulation. 2011;123(21):2363-72. 2. Douxfils J, Mullier F, Robert S, Chatelain C, Chatelain B, Dogne JM. Impact of dabigatran on a large panel of routine or specific coagulation assays. Laboratory recommendations for monitoring of dabigatran etexilate. Thromb Haemost. 2012;107(5):985-97. 3. Connolly SJ, Ezekowitz MD, Yusuf S, Eikelboom J, Oldgren J, Parekh A et al. Dabigatran versus warfarin in patients with atrial fibrillation. N Engl J Med. 2009;361(12):1139-51. 4. Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur J Cardiothorac Surg. 2016;50(5):e1-e88. 5. AbdallahM, Abdallah T, Abi RafehN, Khoueiry G, Abouyassine A, Chalhoub M et al. A sanguineous pleuro pericardial effusion in a patient recently treated with Dabigatran. Heart Lung. 2015;44(3):209-11. 6. Stollberger C, Heger M, Finsterer J. Hemopericardium under dabigatran for stroke prevention in atrial fibrillation. Blood Coagul Fibrinolysis 2017;28(2):185-8. 7. Jelani QU, Gordon R, Schussheim A. Dabigatran-Induced Spontaneous HemopericardiumandCardiacTamponade.TexHeartInstJ.2017;44(5):370-2. 8. BartonCA,McMillianWD,RazaSS,KellerRE.Hemopericardium inapatient treated with dabigatran etexilate. Pharmacotherapy. 2012;32(5):e103-7. 9. Voulgaris T, Anevlavis S, Karpathiou G, Forest F, Koulelidis A, Froudarakis M. Dabigatran can cause eosinophilic pleural and pericardial effusion with blood eosinophilia. Clin Respir J. 2018;12(2):799-801. 10. Song S, Cook J, Goulbourne C, MeadeM, Salciccioli L, Lazar J. First Reported Case of Hemopericardium Related to Dabigatran Use Reversed by New Antidote Idarucizumab. Case Rep Cardiol. 2017;20176458636. 11. Masoomi R, S. Barua R, Parashara D. Spontaneous Hemopericardiumwith Dabigatran Etexilate. J Cardiovasc Dis Res.2015;6(4):179-81. 12. Dy EA, ShiltzDL. Hemopericardiumand cardiac tamponade associatedwith dabigatran use. Ann Pharmacother. 2012;46(7-8):e18. 13. Kizilirmak F, Gunes HM, Guler E, Demir GG, Karaca O, Canpolat HG. Hemopericardium and Cardiac Tamponade in a Patient Treated with Dabigatran Etexilate. Korean Circ J. 2016;46(1):99-101. 14. Ye CG, Wu WK, Yeung JH, Li HT, Li ZJ, Wong CC et al. Indomethacin and SC236 enhance the cytotoxicity of doxorubicin in human hepatocellular carcinoma cells via inhibiting P-glycoprotein andMRP1 expression. Cancer Lett. 2011;304(2):90-6. 15. Pollack CV, Jr., Reilly PA, van Ryn J, Eikelboom JW, Glund S, Bernstein RA et al. Idarucizumab for Dabigatran Reversal - Full Cohort Analysis. N Engl J Med .2017;377(5):431-41. References This is an open-access article distributed under the terms of the Creative Commons Attribution License 15