ABC | Volume 114, Nº4, April 2020

Brief Communication Miranda et al. Ranolazine and type 3 long QT syndrome Arq Bras Cardiol. 2020; 114(4):732-735 This is an open-access article distributed under the terms of the Creative Commons Attribution License 1. Deo R, Albert CM. Epidemiology and genetics of sudden cardiac death. Circulation. 2012;125(4):620-37. 2. Bohnen MS, Peng G, Robey SH, Terrenoire C, Iyer V, Sampson KJ, et al. Molecular pathophysiology of congenital long QT syndrome. Physiol Rev. 2017;97(1):89-134. 3. Clark RB, Giles WR. Current-voltage relationship for late Na(+) current in adult rat ventricular myocytes. Curr Top Membr. 2016;78:451-78. 4. Santos-Miranda A, Cruz JS, Roman-Campos D: Electrical properties of isolated cardiomyocytes in a rat model of thiamine deficiency. Arq Bras Cardiol. 2015;104(3):242-5. 5. SantosMS, Oliveira ED, Santos-Miranda A, Cruz JS, GondimANS, Menezes- Filho JER, et al. Dissection of the effects of quercetin onmousemyocardium. Basic Clin Pharmacol Toxicol. 2017;120(6):550-9. 6. IyerV,Roman-CamposD,SampsonKJ,KangG,FishmanGI,KassRS.Purkinje cells as sources of arrhythmias in long QT syndrome type 3. Sci Rep. 2015 Aug 20;5:13287. 7. Rosati B, Grau F, McKinnon D. Regional variation in mRNA transcript abundance within the ventricular wall. J Mol Cell Cardiol. 2006;40(2):295-302. 8. Fraser H, Belardinelli L, Wang L, Light PE, McVeigh JJ, Clanachan AS: Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat hearts. J Mol Cell Cardiol. 2006;41(6):1031-8. 9. Allen TJ, Chapman RA. Effects of ranolazine on L-type calcium channel currents in guinea-pig single ventricular myocytes. Br J Pharmacol. 1996;118(2):249-54. 10. Honen BN, Saint DA: Heterogeneity of the properties of INa in epicardial and endocardial cells of rat ventricle. Clin Exp Pharmacol Physiol. 2002;29(3):161-6. 11. Chaitman BR, Skettino SL, Parker JO, Hanley P, Meluzin J, Kuch J, et al. Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina. J Am Coll Cardiol. 2004;43(8):1375-82. References 735

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