ABC | Volume 114, Nº3, March 2020

Original Article Leocádio et al. Netrin-1 and IL-1 β : prognosis in ACS Arq Bras Cardiol. 2020; 114(3):507-514 Figure 1 – Kaplan-Meier curves for Netrin-1 (A – C) and IL-1Β (D – F) in older (>60 years) females considering a 2-year follow-up. IL-1β: Interleukin - 1beta. MI: myocardial infarction. Netrin-1: all cause mortality Netrin-1: cardiovascular mortality IL-1β: all cause mortality IL-1β: cardiovascular mortality Netrin-1: fatal or new non-fatal MI IL-1β: fatal or new non-fatal MI Survival probability (%) Survival probability (%) Survival probability (%) Survival probability (%) Survival probability (%) Survival probability (%) Days Days Days Days Days Days Low High Low High Low High Low High Low High Low High p = 0.011 p = 0.123 p = 0.031 p = 0.024 p = 0.067 p = 0.064 100 80 60 40 20 0 100 80 60 40 20 0 100 80 60 40 20 0 100 80 60 40 20 0 100 80 60 40 20 0 100 80 60 40 20 0 0 200 400 600 800 0 200 400 600 800 0 200 400 600 800 0 200 400 600 800 0 200 400 600 800 0 200 400 600 800 A B C D E F Table 4 – Outcomes according to the IL-1β in females Female - Total < 60 years > 60 years 2 years follow-up Low IL-1β High IL-1β p Low IL-1β High IL-1β p Low IL-1β High IL-1β p All-cause mortality 21 (42.0) 29 (58.0) 0.221 0 (0.0) 3 (100.0) 0.118 19 (40.4) 28 (59.6) 0.140 Cardiovascular mortality 12 (35.3) 22 (64.7) 0.071 0 (0.0) 3 (100.0) 0.118 10 (32.3) 21 (67.7) 0.034 Fatal or new non-fatal MI 10 (35.7) 18 (64.3) 0.117 2 (33.3) 4 (66.7) 0.438 7 (31.8) 15 (68.2) 0.075 Values are n (%). IL-1β: Interleukin - 1beta. MI: myocardial infarction. Chi-square test. 511