ABC | Volume 114, Nº3, March 2020

Original Article Kurmus et al. Discordance of lipoproteins and CAD severity Arq Bras Cardiol. 2020; 114(3):469-475 Table 2 – Characteristics of patients with concordant and discordant LDL-C and non-HDL-C LDL-C < median non-HDL-C < median n = 245 (group 1) LDL-C < median non-HDL-C ≥ median n = 43 (group 2) LDL-C ≥ median Non-HDL-C < median n = 43 (group 3) LDL-C ≥ median Non-HDL-C ≥ median n = 243 (group 4) p-value Age (years) 62.0 ± 12.5 58.6 ± 11.7 61.4 ± 10.8 60.7 ± 10.2 0.266 Female gender (%) 35.9 41.9 44.2 49.0 0.036 Smoking (%) 34.3 30.2 30.2 30.6 0.818 Hypertension (%) 50.6 53.5 41.9 49.2 0.704 Diabetes (%) 34.7 46.5 20.9 24.3 0.004 Receiving statin (%) 45.3 18.6 30.2 24.4 0.001 BMI (kg/m 2 ) 28.5 ± 4.0 29.1 ± 4.9 29.1 ± 3.0 29.0 ± 4.2 0.501 Total cholesterol (mg/dl) 156.4 ± 27.2 208.2 ± 20.4 190.1 ± 16.8 240.7 ± 35.3 < 0.001 a,b,c,d,e,f LDL-C (mg/dl) 84.2 ± 18.9 103.0 ± 11.3 126.6 ± 8.5 151.8 ± 26.8 < 0.001 a,b,c,d,e,f HDL-C (mg/dl) 40.1 ± 11.7 36.1 ± 9.5 46.6 ± 13.4 43.7 ± 10.1 < 0.001 a,b,c,d,e, f Non-HDL-C (mg/dl) 116.4 ± 23.4 172.1 ± 19.2 143.4 ± 13.1 197.0 ± 34.6 < 0.001 a,b,c,d,e,f Triglyceride (mg/dl) 132.0 ± 81.6 256.1 ± 118.3 127.8 ± 60.4 184.5 ± 96.5 < 0.001 a,,c,d,e,f Fasting glucose (mg/dl) 121.1 ± 50.4 119.4 ± 40.4 107.4 ± 20.9 108.5 ± 30.9 0.003 b,c Mean Gensini score 24.7 ± 38.1 28.2 ± 36.4 18.7 ± 28.1 26.5 ± 40.1 0.635 Mean SYNTAX score 7.1 ± 11.2 6.7 ± 11.3 5.4 ± 9.3 7.4 ± 11.6 0.733 Gensini score = 0 (%) 24.9 30.2 23.3 23.9 0.837 SYNTAX score = 0 (%) 55.1 60.5 58.1 54.3 0.821 Gensini score ≥ 20 (%) 34.7 27.9 30.2 34.2 0.799 SYNTAX score > 22 (%) 13.5 9.3 11.6 12.8 0.891 Data are expressed as percentage for categorical variables; chi-square test was used. Data are expressed as mean±standard deviation for continuous variables; one-way ANOVA was used; Statistically significant p-values are in bold. LSD test was performed for binary comparisons between groups and the p-value was set at 0.05. Significant differences were found between a) group I vs group II, b) group I vs group III, c) group I vs group IV, d) group II vs group III, e) group II vs group IV, f) group III vs group IV. LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; Non-HDL-C: non-high-density lipoprotein cholesterol; BMI: Body Mass Index. Table 3 – Correlation of LDL-C, non-HDL-C, Gensini and SYNTAX scores with Spearman’s rho and p-value LDL-C < median Non-HDL-C < median n = 245 (group 1) LDL-C < median Non-HDL-C ≥ median n = 43 (group 2) LDL-C ≥ median Non-HDL-C < median n = 43 (group 3) LDL-C ≥ median Non-HDL-C ≥ median n = 243 (group 4) Gensini score SYNTAX score Gensini score SYNTAX score Gensini score SYNTAX score Gensini score SYNTAX score LDL-C r = 0.118 r = 0.101 r = 0.088 r = 0.18 r = 0.127 r = 0.029 r = 0.031 r = 0.002 p = 0.064 p = 0.115 p = 0.577 p = 0.910 p = 0.418 p = 0.853 p = 0.635 p = 0.972 Non-HDL-C r = 0.046 r = 0.031 r = 0.190 r = 0.165 r = 0.104 r = 0.183 r = 0.025 r = 0.034 p = 0.469 p = 0.624 p = 0.221 p = 0.290 p = 0.506 p = 0.240 p = 0.694 p = 0.596 LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; Non-HDL-C: non-high-density lipoprotein cholesterol. Author contributions Conception and design of the research and Critical revision of the manuscript for intellectual content: Kurmus O, Erkan AF, Ekici B, Eren M; Acquisition of data, Statistical analysis and Writing of the manuscript: Kurmus O, Aslan T, Eren M; Analysis and interpretation of the data: Kurmus O, Erkan AF, Ekici B, Aslan T, Eren M. Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. Sources of Funding There were no external funding sources for this study. 473