ABC | Volume 114, Nº2, February 2020

Original Article Rocha et al. Association between periodontitis, polymorphisms and CAD Arq Bras Cardiol. 2020; 114(2):268-272 This is an open-access article distributed under the terms of the Creative Commons Attribution License 13. Slocum C, Kramer C, Genco CA. Immune dysregulation mediated by the oral microbiome: potential link to chronic inflammation and atherosclerosis. J Intern Med. 2016;280(1):114-28. 14. Almeida APCPSC, Fagundes NCF, Maia LC, Lima RR. Is there an association between periodontitis and atherosclerosis in adults? a systematic review. Curr Vasc Pharmacol. 2018;16(6):569-82. 15. Hermann M, Fischer D, Hoffmann MM, Gasser T, Quitzau K, Meinertz T et al. CRP andCD14 polymorphisms correlatewith coronary plaque volume in patients with coronary artery disease--IVUS substudy of the ENCORE trials. Atherosclerosis. 2012;220(1):172-6. 16. Zanella SM, Souza LV, Suzigan BH, Saba-Chujfi E, Barbisan JN. The association between oral health and atherosclerotic coronary artery disease in patients submitted to coronary angiography: a controlled cross-sectional study. Rev Bras Cardiol Invasiva. 2012;20(2):178-83. 17. Lima-Neto LG, Hirata RD, Luchessi AD, Silbiger VN, Stephano MA, Sampaio MF et al. CD14 and IL6 polymorphisms are associated with a pro-atherogenic profile in young adults with acute myocardial infarction. J Thromb Thrombolysis. 2013;36(3):332-40. 18. Mao L, Geng GY, Han WJ, Zhao MH, Wu L, Liu HL. Interleukin-6 (IL-6) -174G/C genomic polymorphism contribution to the risk of coronary artery disease in a Chinese population. Genet Mol Res. 2016;15(2). 19. Aarabi G, Heydecke G, Seedorf U. Roles of oral infections in the pathomechanism of atherosclerosis. Int J Mol Sci. 2018;19(7):pii:E1978. 20. Mastana S, Prakash S, AkamEC, KirbyM, LindleyMR, Sinha N et al. Genetic association of pro-inflammatory cytokine gene polymorphisms with coronary artery disease (CAD) in a North Indian population. Gene. 2017 Sept 10; 628:301-7. 21. Brasil. Ministério da Saúde. SB Brasil 2010: Pesquisa Nacional de Saúde Bucal: resultados principais [internet]. Brasília: Ministério da Saúde; 2012. [acesso em 18 out 2019]. Disponível em: http://bvsms.saude.gov.br/bvs/ publicacoes/pesquisa_nacional_saude_bucal.pdf. 22. Trevilatto PC, Scarel-Caminaga RM, de Brito Jr. RB, de Souza AP, Line SR. Polymorphismatposition-174of IL-6 gene is associatedwith susceptibilityto chronic periodontitis in a Caucasian Brazilian population. J Clin Periodontol. 2003;30(5):438-42. 23. Beukers NG, van der Heijden GJ, van Wijk AJ, Loos BG. Periodontitis is an independent risk indicator for atherosclerotic cardiovascular diseases among 60,174 participants in a large dental school in the Netherlands. J Epidemiol Community Health. 2017;71(1):37-42. 24. Lawlor DA, Harbord RM, Timpson NJ, Lowe GD, Rumley A, Gaunt TR et al. The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases among 18,637 participants. PLoS One. 2008;3(8):e3011. 25. Tibaut M, Caprnda M, Kubatka P, Sinkovi ĉ A, Valentova V, Filipova S et al. Markers of atheosclerosis: part 1 – serological markers. Heart, Lung Circ. 2018;28(5):667-77. 26. Sakata K, Gamou T, Tada H, Hayashi K, Ino H, Yamagishi M, et al. Low baseline high-sensitive C-reactive protein is associated with coronary atherosclerosis regression: insights from the MILLION study. J Atheroscler Thromb. 2019;26(5):442-51. 27. Carvalho VCV, Silva LCA, Werkhauser RP, Montenegro ST, Silva CGR, Gomes AV, et al. Evaluation of IL-6 (-174 G/C) Polymorphism in Acute Coronary Syndrome in the Northeast of Brazil. Int J Cardiovasc Sci. 2016;29(4):288-94. 272