ABC | Volume 114, Nº2, February 2020

Original Article Gonçalves et al. Prediction of CPET in HF patients with AF Arq Bras Cardiol. 2020; 114(2):209-218 Table 1 – Baseline characteristics of AF and SR groups SR - n = 223 AF - n = 51 p for ≠ between groups Clinical data – characteristics Age 52.61 ± 12.53 57.96 ± 8.61 < 0.001 Female (%) 61 (27.4%) 6 (11.8%) 0.019 BMI 1 (kg/m 2 ) 26.80 ± 4.07 27.47 ± 4.78 0.361 Ischemic etiology (%) 90 (40.4%) 14 (27.5%) 0.087 ACEi 2 /ARA 3 (%) 211 (96.3%) 50 (98.0%) 0.544 BB 4 (%) 179 (80.3%) 40 (78.4%) 0.768 MRA 5 (%) 184 (72.2%) 38 (74.5%) 0.677 Diabetes (%) 43 (21.4%) 10 (22.7%) 0.846 Baseline 6 ICD (%) 109 (49.8%) 27 (52.9%) 0.493 Baseline 7 CRT (%) 48 (21.5%) 12 (23.5%) 0.781 HFSS 8 8.77 ± 0.95 8.22 ± 0.93 < 0.001 Laboratorial data Glomerular filtration rate (ml/min) 76.84 ± 30.20 65.03 ± 29.05 0.012 Sodium (mEq/L) 137.8 (135.7-139.3) 136.9 (133.6-139.3) 0.052 NT-proBNP (pg/ml) 2,046.79 ± 2,223.07 3,247.38 ± 4,578.571 0.097 Echocardiographic data LVEDD 9 (mm/m 2 ) 38 (35-43) 38 (35-43) 0.237 LVEF 10 (%) 29 (22-34) 26 (20-30) 0.010 MR III-IV 11 (%) 87 (39.0%) 12 (23.5%) 0.073 RV dysfunction (%) 29 (13.0%) 22 (40%) < 0.001 CPET data Initial HR 13 82 (72-92) 83 (70-100) 0.232 Maximal HR 137 (121-157) 130 (115-179) 0.747 Maximal HR predicted (%) 82.77 ± 12.86 86.88 ± 23.37 0.230 Delta HR during exercise 53 (39-71) 52 (34-64) 0.636 HHR1 14 17 (12-26) 16 (10-25) 0.624 Initial SBP 15 115 (110-125) 1,110 (100-120) 0.026 Maximal SBP 155.30 ± 26.83 145.92 ± 28.98 0.028 Duration of CPET 16 (min) 10.83 ± 3.99 8.53 ± 4.30 < 0.001 Peak RER 17 1.10 ± 0.09 1.11 ± 0.09 0.340 pVO 2 (ml/kg/min) 20.27 ± 5.54 17.81 ± 5.55 0.005 pVO 2 predicted (%) 68.12 ± 17.65 63.12 ± 18.29 0.072 VE/VCO 2 slope 30.64 ± 6.78 34.33 ± 8.88 0.006 OUES 1.83 ± 0.58 1.64 ± 0.60 0.035 AT 18 time (minutes) 7.49 ± 3.44 5.49 ± 3.63 < 0.001 pVO 2 (ml/kg/min) at AT 16.35 ± 4.29 14.29 ± 4.32 0.002 Values are mean ± standard deviation or median (interquartile range); p values are calculated by Student´s T-test for independent samples or Mann-Whitney U test as appropriate. SR: sinus rhythm; AF: atrial fibrillation; BMI: body mass index; ACEi: angiotensin-converting enzyme inhibitors; ARA: angiotensin receptor blockers; BB: beta-blockers; MRA: mineralocorticoid receptor antagonists; ICD: implantable cardioverter-defibrillator; CRT: cardiac resynchronization therapy; HFSS: Heart Failure Survival Score; LVEDD: left ventricular end-diastolic diameter; LVEF: left ventricular ejection fraction; MR: mitral regurgitation; RV: right ventricular; HR: heart rate; HRR1: heart rate recovery in the first minute after finishing CPET; SBP: systolic blood pressure; CPET: cardiopulmonary exercise test; RER: respiratory exchange ratio; AT: anaerobic threshold. 211