ABC | Volume 114, Nº1, January 2019

Review Article Fernandes et al. Heart Failure with Preserved Ejection Fraction Arq Bras Cardiol. 2020; 114(1):120-129 This is an open-access article distributed under the terms of the Creative Commons Attribution License 22. KosmalaW, HollandDJ, Rojek, Wright L, Przewlocha-KosmalaM, Marwick TH. Effect of If -Channel Inhibition on Hemodynamic Status and Exercise. 23. Ahmed A, RichMW, Fleg JL, ZileMR, Young JB, KitzmanDW, et al. Effects of Digoxin onMorbidity andMortality inDiastolic Heart Failure: The Ancillary Digitalis Investigation Group Trial. Circulation. 2006;114(5):397-403. 24. Redfield MM, Anstrom KJ, Levine JA, Koepp GA, Borlaug BA, Chen HH, et al. IsosorbideMononitrate inHeart Failurewith Preserved Ejection Fraction. N Engl J Med. 2015;373(24):2314-24. 25. Zamani P, Rawat D, Shiva-Kumar O, Geraci S, Bhuva R, Konda P, et al. The Effect of Inorganic Nitrate on Exercise Capacity in Heart Failure with Preserved Ejection Fraction. Circulation . 2015;131(4):371-80. 26. Redfield MM, Chen HH, Borlaug BA, Semigran MJ, Lee KL, Lewis G, et al. Effect of Phosphodiesterase-5 Inhibition on Exercise Capacity and Clinical Status in Heart Failure With Preserved Ejection Fraction. JAMA. 2013;309(12):1268-77. 27. Bonderman D, Prestch I, Steringer-Mascherbauer R, Jansa P, Rosenkranz S, Tufaro C, et al. Acute Hemodynamic Effects of Riociguat in Patients With PulmonaryHypertensionAssociatedWithDiastolicHeart Failure (DILATE-1) A Randomized, Double-Blind, Placebo-Controlled, Single-Dose Study. Chest. 2014;146(5):1274-85. 28. Pieske B, Maggioni AP, Lam CSP, Pieske-Kraigher E, Filippatos G, Butler J, et al. Vericiguat in patients withworsening chronic heart failure and preserved ejection fraction: results of the SOluble guanylate Cyclase stimulatoR in heArT failure patients with PRESERVED EF (SOCRATES-PRESERVED) study. Eur Heart J. 2017;38(15):1119-27. 29. Maier L, Layug BL, Karwatowska-Prokopczuk E, Belardinelli L, Lee S, Sander J, et al. RAnoLazIne for the Treatment of Diastolic Heart Failure in Patients With Preserved Ejection Fraction. JACC Hear Fail. 2013;1(2):22-115. 30. Reddy YNV, Obokata M, Koepp KE, Egbe AC, Wiley B, Borlaug BA. The B-adrenergicagonistAlbuterolImprovesPulmonaryVascularReserve inHeart Failure with Preserved Ejection Fraction. Circ Res. 2019;124(2):306-14. 31. Hasenfuß G, Hayward C, Burkhoff D, Silvestry FE, McKenzie S, Gustafsson F, et al. A transcatheter intracardiac shunt device for heart failure with preserved ejection fraction (REDUCE LAP-HF): a multicentre ,open-label, single-arm, phase 1 trial. Lancet. 2016;387(10025):1298-304. 32. KayeDM, HasenfußG, Neuzil P, Post MC, Doughty R, Trochu JN, et al. One- Year Outcomes After Transcatheter Insertion of an Interatrial Shunt Device for theManagement of Heart FailureWith Preserved Ejection Fraction. Circ Heart Fail. 2016 Dec;9(12). pii: e003662. 33. 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Effect of IV Iron (Ferric Carboxymaltose, Ferinject) on Exercise Tolerance, Symptoms andQuality of Life in PatientsWithHeart FailureWith Preserved Ejection Fraction (HFpEF) and IronDeficiencyWith andWithout Anaemia [Internet]. Berlin, Germany: Charite University; 2017 August 1 [Last Update 2017 August 24]. Available from: https://clinicaltrials.gov/ct2/ show/NCT03074591. 41. Seferivic PM, Petrie MC, Filippatos GS, Anker SD, Rosano G, Bauersachs J, et al. Type 2 diabetes mellitus and heart failure: a position statement from the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2018;20(5):853-72. 42. Zinman B, Wanner C, Lachin JM, Fitchett D, Bluhmki E, Hantel S, et al. Empagliflozin, Cardiovascular Outcomes, andMortality in Type 2Diabetes. N Engl J Med. 2015;373(22):2117-28. 43. Neal B, Perkovic V, Mahaffey KW, Zeeuw D, Fulcher G, Erondu N, et al. Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes. N Engl J Med. 2017;377(7):644-57. 44. 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