ABC | Volume 114, Nº1, January 2019

Original Article Brianezi et al. Effects of physical training on the myocardium Arq Bras Cardiol. 2020; 114(1):100-105 1. ZanescoA,AntunesE.Effectsofexercisetrainingonthecardiovascularsystem: pharmacological approaches. Pharmacol Ther. 2007;114(3):307-17. 2. Coylewright M, Reckelhoff JF, Ouyang P. Menopause and hypertension: an age-old debate. Hypertension. 2008;51(4):952-9. 3. Humphreys V, Martin RM, Ratcliffe B, Duthie S, Wood S, Gunnell D, et al. Age-related increases in DNA repair and antioxidant protection: a comparison of the Boyd Orr Cohort of elderly subjects with a younger population sample. Age Ageing. 2007;36(5):521-6. 4. Lee HC, Wei YH. Oxidative stress, mitochondrial DNA mutation, and apoptosis in aging. Exp Biol Med (Maywood). 2007; 232 (5): 592-606. 5. David OJ, Ocwieja M, Meiser K, Emotte C, Jakab A, Wemer J, et al. Pharmacokineticsoffingolimod (FTY720)andacombinedoralcontraceptive coadministered in healthy women: drug-drug interaction study results. Int J Clin Pharmacol Ther. 2012;50(8):540-4. 6. Gobal FA, Mehta JL. Management of dyslipidemia in the elderly population. Ther Adv Cardiovasc Dis. 2010;4(6):375-83. 7. Ammar T. Effects of aerobic exercise on blood pressure and lipids in overweight hypertensive postmenopausal women. J Exerc Rehabil. 2015;11(3):145-50. 8. Perrella J, Berco M, Cecutti A, Gerulath A, Bhavnani BR. Potential role of the interaction between equine estrogens, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) in the prevention of coronary heart and neurodegenerative diseases in postmenopausal women. Lipids Health Dis. 2003 Jun 20;2:4. 9. Irigoyen MC, Paulini J, Flores LJ, Flues K, Bertagnolli M, Moreira ED, et al. Exercisetrainingimprovesbaroreflexsensitivityassociatedwithoxidativestress reduction in ovariectomized rats. Hypertension. 2005;46(4):998-1003. 10. ValençaCN,NascimentoFilhoJM,GermanoRM.Mulhernoclimatério:reflexões sobre desejo sexual, beleza e feminilidade. Saude Soc. 2010;19(2):273-85. 11. Mandarim-de-Lacerda CA, Pessanha MG. Stereology of the myocardium in embryos,fetusesandneonatesoftherat.ActaAnat(Basel).1995;154(4):261-6. 12. Maifrino LBM, Araújo RC, Faccini CC, Liberti EA, Gama EF, Ribeiro AA, et al. Effect of exercise training on aging-induced changes in rat papillary muscle. Arq Bras Cardiol. 2009;92(5):356-60,373-7,387-92. 13. Souza SB, Flues K, Paulini J, Mostarda C, Rodrigues B, Souza LE, et al. Role of exercise training in cardiovascular autonomic dysfunction and mortality in diabetic ovariectomized rats. Hypertension. 2007;50(4):786-91. 14. Silva AS, Zanesco A. Exercício físico, receptores β -adrenérgicos e resposta vascular. J Vasc Bras. 2010;9(2):47-56. 15. Morvan E, Lima NE, Machi JF, Mostarda C, De Angelis K, Irigoyen MC, et al. Metabolic, hemodynamic and structural adjustments to low intensity exercise traininginametabolicsyndromemodel.CardiovascDiabetol.2013Jun18;12:89. 16. MarcondesFK,BianchiFJ,TannoAP.Determinationoftheestrouscyclephases of rats: some helpful considerations. Braz J Biol. 2002; 62(4A): 609-14. 17. Biondo-Simões MLP, Alcantara EM, Dallagnol JC, Yoshizumi KO, Torres LFB, Borsato KS. Cicatrização de feridas: estudo comparativo em ratos hipertensos não tratados e tratados com inibidor da enzima conversora da angiotensina. Rev Col Bras Cir. 2006:33(2):74-8. References The expression of COX2 in our study did not present statistical significance, indicating that in all groups and parameters, there were no changes for these data. Thus, in this parameter chosen to verify inflammation, no changes are observed showing that the factors associated with the groups do not interfere in such an evaluation. Aging, menopause and dyslipidemia are factors that also result in oxidative stress. 3-5 In our research, oxidative stress was verified through the expression of 8OHdG, and ovariectomy decreased the values of this parameter in the control and dyslipidemic groups, differing from the results obtained in other studies. 5,35 When physical trainingwas performed, the values were decreased in the control group, but in the dyslipidemic group, they presented an increase. Interestingly, thismarker seems to have no association with the groups proposed in this experimental model. Conclusion The data of this research indicate that physical exercise beneficially influenced the control and dyslipidemic groups in the volume density parameter of type I collagen fibers and the control group in relation to oxidative stress. Author contributions Conception and design of the research: Brianezi L, Maifrino LBM; Acquisition of data: Brianezi L, Ornelas E, Sousa LVA; Analysis and interpretation of the data: Brianezi L, Ornelas E, Gehrke FS, Fonseca FLA, Sousa LVA, Souza J, Maifrino LBM; Statistical analysis: Brianezi L, Gehrke FS, Fonseca FLA, Souza J; Writing of the manuscript: Brianezi L, Ornelas E, Gehrke FS, Fonseca FLA, Alves BCA, Sousa LVA, Maifrino LBM; Critical revision of the manuscript for intellectual content: Gehrke FS, Fonseca FLA, Alves BCA, Maifrino LBM. Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. Sources of Funding There were no external funding sources for this study. Study Association This study is not associatedwith any thesis or dissertationwork. Ethics approval and consent to participate This study was approved by the Ethics Committee of the Universidade de São Judas Tadeu under the protocol number 058. All the procedures in this study were in accordance with the 1975 Helsinki Declaration, updated in 2013. 104