ABC | Volume 113, Nº6, December 2019

Review Article Ferrari et al. Exercise-mediated glucose uptake Arq Bras Cardiol. 2019; 113(6):1139-1148 84. Hameed I, Masoodi SR, Mir SA, Nabi M, Ghazanfar K, Ganai BA. Type 2 diabetes mellitus: Fromametabolic disorder to an inflammatory condition. World J Diabetes. 2015;6(4):598-612. 85. Tak PP, Firestein GS. NF-kappaB: a key role in inflammatory diseases. J Clin Invest. 2001;107(1):7-11. 86. Agrawal NK, Kant S. Targeting inflammation in diabetes: Newer therapeutic options. World J Diabetes. 2014;5(5):697-710. 87. Kang YE, Kim JM, Joung KH, Lee JH, You BR, Choi MJ, et al. The Roles of Adipokines, Proinflammatory Cytokines, and Adipose TissueMacrophages in Obesity-Associated Insulin Resistance in Modest Obesity and Early Metabolic Dysfunction. PLoS One. 2016;11(4):e0154003. 88. Song MJ, Kim KH, Yoon JM, Kim JB. Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochem Biophys Res Commun. 2006;346(3):739-45. 89. Jin C, Flavell RA. Innate sensors of pathogen and stress: linking inflammation to obesity. J Allergy Clin Immunol. 2013;132(2):287-94. 90. Watanabe Y, Nagai Y, Takatsu K. Activation and regulation of the pattern recognition receptors in obesity-induced adipose tissue inflammation and insulin resistance. Nutrients. 2013;5(9):3757-78. 91. Kim JJ, Sears DD. TLR4 and Insulin Resistance. Gastroenterol Res Pract. 2010 Aug;2010:212563. 92. Guo S. Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms. J Endocrinol. 2014;220(2):T1-23. 93. Barma P, Bhattacharya S, Bhattacharya A, Kundu R, Dasgupta S, Biswas A, et al. Lipid induced overexpression of NF-kappaB in skeletal muscle cells is linked to insulin resistance. BiochimBiophys Acta. 2009;1792(3):190-200. 94. Copps KD, White MF. Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2. Diabetologia. 2012;55(10):2565-82. 95. Sun S, Ji Y, Kersten S, Qi L. Mechanisms of inflammatory responses in obese adipose tissue. Annu Rev Nutr. 2012 Mar;32:261-86. 96. Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest. 2003;112(12):1785-8. 97. Shimobayashi M, Albert V, Woelnerhanssen B, Frei IC, Weissenberger D, Meyer-Gerspach AC, et al. Insulin resistance causes inflammation in adipose tissue. J Clin Invest. 2018;128(4):1538-50. 98. Wang X, You T, Murphy K, LylesMF, Nicklas BJ. Addition of Exercise Increases Plasma Adiponectin and Release fromAdipose Tissue. Med Sci Sports Exerc. 2015;47(11):2450-5. 99. Kesherwani V, Chavali V, Hackfort BT, Tyagi SC, Mishra PK. Exercise ameliorates high fat diet induced cardiac dysfunction by increasing interleukin 10. Front Physiol. 2015 Apr;6:124. 100.KeaneKN,CruzatVF,CarlessiR,deBittencourtPI Jr,NewsholmeP.Molecular Events Linking Oxidative Stress and Inflammation to Insulin Resistance and beta-Cell Dysfunction. Oxid Med Cell Longev. 2015 Jul;2015:181643. 10. Pedersen BK. Anti-inflammatory effects of exercise: role in diabetes and cardiovascular disease. Eur J Clin Invest. 2017;47(8):600-11. 102.Ellingsgaard H, Hauselmann I, Schuler B, Habib AM, Baggio LL, Meier DT, et al. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nat Med. 2011;17(11):1481-9. 103.Kalra S, Baruah MP, Sahay RK, Unnikrishnan AG, Uppal S, Adetunji O. Glucagon-like peptide-1 receptor agonists in the treatment of type 2 diabetes: Past, present, and future. Indian J Endocrinol Metab. 2016;20(2):254-67. 104.Musi N, Fujii N, HirshmanMF, Ekberg I, Froberg S, Ljungqvist O, et al. AMP- activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise. Diabetes. 2001;50(5):921-7. 105.O’GormanDJ, KarlssonHK, McQuaid S, Yousif O, Rahman Y, GasparroD, et al. Exercise training increases insulin-stimulated glucose disposal andGLUT4 (SLC2A4) protein content in patients with type 2 diabetes. Diabetologia. 2006;49(12):2983-92. 106.Prudente S, Sesti G, Pandolfi A, Andreozzi F, Consoli A, Trischitta V. The mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseases. Endoc Rev. 2012;33(4):526-46. 107. MatosA,RopelleER,PauliJR,FredericoMJ,dePinhoRA,VellosoLA,etal.Acute exercisereversesTRB3expressionintheskeletalmuscleandameliorateswhole body insulinsensitivity indiabeticmice.ActaPhysiol (Oxf).2010;198(1):61-9. 108.Rodrigues BA, Pauli LS, Souza CT, Silva AS, CintraDE, Marinho R, et al. Acute Exercise Decreases Tribbles Homolog 3 Protein Levels in theHypothalamus of Obese Rats. Med Sci Sports Exerc. 2015;47(8):1613-23. 109.WangM, Li S, Wang F, Zou J, Zhang Y. Aerobic exercise regulates blood lipid and insulin resistance via the toll-like receptor 4-mediated extracellular signal-regulated kinases/AMP-activated protein kinases signaling pathway. Mol Med Rep. 2018;17(6):8339-48. 110.Saunders TJ, Palombella A, McGuire KA, Janiszewski PM, Despres JP, Ross R. Acute exercise increases adiponectin levels in abdominally obese men. J Nutr Metab. 2012 May;2012:148729. 111.Wang ZV, Scherer PE. Adiponectin, the past two decades. J Mol Cell Biol. 2016;8(2):93-100. 112.Fang H, Judd RL. Adiponectin Regulation and Function. Compr Physiol. 2018;8(3):1031-63. 113. ElluluMS, Patimah I, Khaza’ai H, Rahmat A, Abed Y. Obesity and inflammation: thelinkingmechanismandthecomplications.ArchMedSci.2017;13(4):851-63. 114.Hong HR, Jeong JO, Kong JY, Lee SH, Yang SH, Ha CD, et al. Effect of walking exercise on abdominal fat, insulin resistance and serum cytokines in obese women. 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A role for calcium in resistin transcriptional activation in diabetic hearts. Sci Rep. 2018;8(1):15633. 120.Kaplon-Cieslicka A, Tyminska A, Rosiak M, Ozieranski K, Peller M, Eyileten C, et al. Resistin is a prognostic factor for death in type 2 diabetes. Diabetes Metab Res Rev. 2019;35(2):e3098. 121.Cobbold C. Type 2 diabetes mellitus risk and exercise: is resistin involved? J Sports Med Phys Fitness. 2019;59(2):290-7. 1147