ABC | Volume 113, Nº6, December 2019

Original Article Celebi et al. NT-pro BNP and left ventricular aneurysm Arq Bras Cardiol. 2019; 113(6):1129-1137 Figure 1 – Patients flow chart demonstrating the number of patients eligible for inclusion into the study. Assessed for eligibility n = 2,458 Excluded Not meeting inclusion criteria: 921 Refuse to participate: 18 Enrolled n = 1,519 Death before the echocardiographic examination or lost follow-up n = 103 Final analysis n = 1,416 LVA+ n = 157 LVA– n = 1,259 ischemia causes infarct tissue and LVA. Thus, we observed high levels of NT-pro BNP before the development of LVA. Conclusion In this study, we found that in the modern treatment era of acute STEMI, there are new factors such as reperfusion therapy or P2Y12 inhibitors that affect the development of LVA. We also found that NT-pro BNP > 400 pg/dL measured during the first 12 hours of acute STEMI is a good predictor of LVA formation. To the best of our knowledge, no previously published studies have demonstrated the relationship between admission NT-pro BNP levels and LVA formation after acute MI. Therefore, we concluded that a single measurement of NT-pro BNP at admission in patients with acute STEMI proves useful for the estimation of LVA development. Limitations First, we measured the NT-pro BNP levels only at admission. Serial measurement may give more information about LVA development. Second, we only determined the LVA by TTE. Although TTE was performed by two blind echocardiographers, there will still be limitations in detecting the apical aneurysms. Author contributions Conception and design of the research: Celebi S, Celebi OO, Gokaslan S, Berkalp B, Aydogdu S; Acquisition of data and Statistical analysis: Celebi S, Celebi OO, Cetin HO; Analysis and interpretation of the data: Celebi S, Cetin S, Tek M; Writing of the manuscript: Celebi S, Celebi OO, Berkalp B, Aydogdu S; Critical revision of the manuscript for intellectual content: Celebi S, Cetin S, Cetin HO, Tek M, Amasyali B, Berkalp B, Diker E, Aydogdu S. Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. Table 1 – Demographics of study group LV Aneurysm(-) LV Aneurysm (+) p-value Age (years) 55.4 ± 11.0 61.0 ± 13.2 0.048 Gender (M) (n)% (783)62.2 (106)67.5 0.070 BMI 27.4 ± 4.7 28.6 ± 2.9 0.030 Smoking (n) % (673)53.4 (35)22.2 0.011 DM (n) % (319)25.3 (36)22.9 0.803 Previous CABG (n) % (23)1.8 (14)8.9 0.008 Previous PCI (n) % (34)2.7 (2)1.3 0.439 LV: left ventricle; BMI: body mass index; DM: diabetes mellitus; CABG: coronary artery bypass greft; PCI: percutaneous coronary intervention. 1132