ABC | Volume 113, Nº4, October 2019

Original Article Şahiner et al LAA occlusion with amulet device Arq Bras Cardiol. 2019; 113(4):712-721 Figure 1 – a) Transesophageal echocardiography image of the transseptal puncture needle tenting the inferoposterior site of the interatrial septum and atrial septal defect closure device, b) Tridimensional transesophageal echocardiography guidewire image after the transseptal puncture, c) Fluoroscopic image of the transseptal puncture on the inferoposterior site of the interatrial septum and atrial septal defect closure device, d) Fluoroscopic image of the device before being released. evaluated only at the 1 st and 6 th month (Figure 3). No patient showed device thrombus or embolization at any visit. Two (3.3%) patients had significant peri-device leak (>3 mm) at the 1 st and 6 th month visit. These two patients did not present peri-device leak at the 12 th month TEE (Table 2). Discussion We used the AMPLATZER™ Amulet™ LAA occluder for percutaneous LAA occlusion in a series of patients and reported mid-term data on its safety and efficacy. The PROTECT-AF and PREVAIL studies provided large-scale randomized clinical trial evidence that LAA occlusion with the Watchman device could be non-inferior to anticoagulation for CVEs in patients with non-valvular AF. 9,10 On the other hand, large-scale randomized data on other LAA occlusion devices are limited. The AMPLATZER Amulet device is currently being evaluated in a randomized controlled trial (Amulet IDE Trial; ClinicalTrials. gov Identifier: NCT02879448) and long‑term randomized trial data has not been published yet. Thus, real‑life data, multicenter registries, and meta-analysis Figure 2 – Postprocedural antithrombotic treatment. Left Atrial Appendage Occlusion 6 th Month TEE 12 th Month TEE Dual Antiplatelet Therapy n = 52 Dual Antiplatelet Therapy n = 2 Dual Antiplatelet Therapy n = 0 Single Antiplatelet Therapy n = 2 Single Antiplatelet Therapy n = 57 Single Antiplatelet Therapy n = 59 Low Dose Anticoagulant Therapy n = 5 Low Dose Anticoagulant Therapy n = 0 Low Dose Anticoagulant Therapy n = 0 716