ABC | Volume 113, Nº3, September 2019

Original Article Figueiredo et al. Rheumatic fever: a disease without color Arq Bras Cardiol. 2019; 113(3):345-354 Figure 1 – Growth trends and predicted values for Acute Rheumatic Fever (ARF) and Rheumatic Heart Disease (RHD) mortality rates. The model equation for the trend of the ARF (A) mortality rate was ARF MT = –237,79 + 0,12 * Year, whereas for the trend of the RHD mortality rate (C) it was RDH MT = –286,11 + 0,15 * Year. It should be noted that all trends were significant (p-value < 0.050), evidencing the increasing trend of the series over time. 1998 2000 2002 2004 2006 2008 2010 2012 2014 2016 Time 1998 2000 2002 2004 2006 2008 2010 2012 2014 2016 Time 1998 2000 2002 2004 2006 2008 2010 2012 2014 2016 2018 2020 Time 1998 2000 2002 2004 2006 2008 2010 2012 2014 2016 2018 2020 Time Mortality rate Mortality rate Mortality rate 0 5 6 7 8 9 5 6 7 8 9 1 2 3 Mortality rate 0 1 2 3 Time series Trend Time series Trend Time series Adjusted Values Predicted Values Time series Adjusted Values Predicted Values ARF mortality rate over time (A) RHD mortality rate over time (C) Predicted values for ARF mortality rate (B) Predicted values for RHD mortality rate (D) Table 1 – A detailed description of the costs associated with the diagnosis of Acute Rheumatic Fever, as well as the costs of interventional procedures and hospitalizations due to Rheumatic Heart Disease in the context of the public health system of Brazil (values set for 2016) Diagnosis and treatment Procedures Individual cost per procedure (R$) (US$) † Procedures needed for the diagnosis of ARF* Medical consultation 10.00 3.04 Electrocardiogram 5.15 1.56 CRP 2.83 0.86 ESR 2.73 0.83 ASO 2.83 0.86 Oropharyngeal Culture 5.72 1.74 Transthoracic echocardiogram 39.64 12.03 Rapid antigen detection test for GAS 4.33 1.31 Interventional procedures in RHD* Valve repair 6,061.70 1,840.33 Valve replacement 6,321.74 1,919.28 Multiple valve replacement 7,277.56 2,194.28 Percutaneous mitral valvuloplasty 1,739.19 528.01 Hospitalization due to the consequences of RHD* Ischemic stroke 1,635.55 496.55 Heart failure 699.46 212.35 Atrial fibrillation 219.65 66.68 Infective endocarditis 880.00 267.68 ARF:acute rheumatic fever; RHD: rheumatic heart disease; CRP: c-reactive protein; ESR: erythrocyte sedimentation rate; ASO: antistreptolysin O; GAS: group A β-hemolytic Streptococcus. *Data from Jones Criteria, reviewed by the AHA. † The values in US dollars (US$) were obtained on February 8, 2018. One Brazilian Real (R$) was equivalent to US$ 0.3036. Source: The authors. 347