ABC | Volume 113, Nº3, September 2019

Review Article Calderado et al. Pulmonary hypertension Arq Bras Cardiol. 2019; 113(3):419-428 1. Moreira EM, Gall H, Leening MJ, Lahousse L, Loth DW, Krijthe BP, et al. Prevalence of Pulmonary Hypertension in the General Population: The Rotterdam Study. PLoS One. 2015;10(6):e0130072. 2. Vachiery JL, Adir Y, Barbera JA, Champion H, Coghlan JG, Cottin V, et al. Pulmonary hypertension due to left heart diseases. J Am Coll Cardiol. 2013;62(25 Suppl):D100-8. 3. Bermejo J, Yotti R, Garcia-Orta R, Sanchez-Fernandez PL, Castano M, Segovia-Cubero J, et al. Sildenafil for improving outcomes in patients with corrected valvular heart disease and persistent pulmonary hypertension: a multicenter, double-blind, randomized clinical trial. Eur Heart J. 2018;39(15):1255-64. 4. Bursi F, McNallan SM, Redfield MM, Nkomo VT, Lam CS, Weston SA, et al. Pulmonary pressures and death in heart failure: a community study. J Am Coll Cardiol. 2012;59(3):222-31. 5. Hurdman J, Condliffe R, Elliot CA, Swift A, Rajaram S, Davies C, et al. Pulmonary hypertension in COPD: results from the ASPIRE registry. Eur Respir J. 2013;41(6):1292-301. 6. Leary PJ, Maron BA, Tedford RJ, Lahm T. Pulmonary Hypertension: Good Intentions, But a Questionable Approach. Ann Am Thorac Soc. 2018;15(6):664-6. 7. SimonneauG, GatzoulisMA, Adatia I, Celermajer D, Denton C, Ghofrani A, et al. Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol. 2013;62(25 Suppl):D34-41. 8. Maron BA, Hess E, Maddox TM, Opotowsky AR, Tedford RJ, Lahm T et al. Association of Borderline Pulmonary Hypertension With Mortality and Hospitalization in a Large Patient Cohort: Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program. Circulation. 2016; 133(13):1240-8. 9. Simonneau G, Montani D, Celermajer DS, Denton CP, Gatzoulis MA, Krowkaet M, al. Haemodynamic definitions and updated clinical classification of pulmonary hypertension. Eur Respir J. 2019;53(1). 10. Naeije R, Vachiery JL, Yerly P, Vanderpool R. The transpulmonary pressure gradient for the diagnosis of pulmonary vascular disease. Eur Respir J. 2013;41(1):217-23. 11. GalieN, Humbert M, Vachiery JL, Gibbs S, Lang I, Torbicki A, et al. 2015 ESC/ ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT). Eur Heart J. 2016;37(1):67-119. 12. Hoeper MM, Lee SH, Voswinckel R, Palazzini M, Jais X, Marinelli A, et al. Complications of right heart catheterization procedures in patients with pulmonary hypertension in experienced centers. J Am Coll Cardiol. 2006;48(12):2546-52. 13. Gavilanes F, Alves Jr JL, Fernandes C, Prada LF, JardimCV, Morinaga LT, et al. Left ventricular dysfunction in patients with suspected pulmonary arterial hypertension. J Bras Pneumol. 2014;40(6):609-16. 14. Souza R, Fernandes CJ, Jardim CV. Other causes of PAH (schistosomiasis, porto-pulmonary hypertension and hemolysis-associated pulmonary hypertension). Semin Respir Crit Care Med. 2009;30(4):448-57. 15. Alves JL, Jr., Gavilanes F, Jardim C, Fernandes CJ, Morinaga LT, Dias B, et al. Pulmonary arterial hypertension in the southern hemisphere: results froma registry of incident Brazilian cases. Chest. 2015;147(2):495-501. 16. Fernandes CJ, Jardim CV, Hovnanian A, Hoette S, Morinaga LK, Souza R. Schistosomiasis and pulmonary hypertension. Expert Rev Respir Med. 2011;5(5):675-81. 17. Julio Cesar Fernandes C, Piloto B, Castro M, Gavilanes Oleas F, Leonidas Alves J, Jr., Felipe Lopes Prada L, et al. Survival of schistosomiasis-associated pulmonary arterial hypertension in themodernmanagement era. Eur Respir J. 2018; 51(6). 18. Gavilanes F, Fernandes CJ, Souza R. Pulmonary arterial hypertension in schistosomiasis. Curr Opin PulmMed. 2016;22(5):408-14. 19. Alves JL, Jr., Oleas FG, Souza R. Pulmonary Hypertension: Definition, Classification,andDiagnosis.SeminRespirCritCareMed.2017;38(5):561-70. 20. Palazzini M, Dardi F, Manes A, Bacchi Reggiani ML, Gotti E, Rinaldi A, et al. Pulmonaryhypertensiondueto leftheartdisease:analysisofsurvivalaccording to the haemodynamic classification of the 2015 ESC/ERS guidelines and insights for future changes. Eur J Heart Fail. 2018;20(2):248-55. References Conclusion PH is a complex and heterogeneous condition, often wrongly diagnosed when based only on echocardiographic data. For patients with Grupo 1 PH, the use of specific therapeutic approaches are recommended. Unfortunately, for the most common forms of PH: group 2 (cardiac cause) or group 3 (respiratory causes) routine use of specific therapeutic is not indicated. The complexity of the assessment of patients with PH reinforces the need for these patients to be followed in centers with expertise in pulmonary circulation, where multidisciplinary approach allows for optimization of existing resources and treatment adequacy to current guidelines. Author contributions Conception and design of the research, Analysis and interpretation of the data, Writing of the manuscript and Critical revision of the manuscript for intellectual content: Calderaro D, Alves Junior JL, Fernandes CJCS, Souza R. Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. Sources of Funding There were no external funding sources for this study. Study Association This study is not associatedwith any thesis or dissertationwork. Ethics approval and consent to participate This article does not contain any studies with human participants or animals performed by any of the authors. 426