ABC | Volume 113, Nº2, August 2019

Original Article Oliveira et al Cardiovascular risk in psoriasis patients Arq Bras Cardiol. 2019; 113(2):242-249 Table 2 – Ultrasound and oscillometry parameters of the brachial artery Parameters Control group (n = 33) Psoriatic group (n = 11) p-value IVRT (ms) 94 ± 15 104 ± 12 0.106* DT (ms) 180 ± 43 190 ± 36.5 0.322* E/A ratio 0.86 ± 0.47 0.88 ± 0.18 0.456* Lateral E/e’ ratio 5.96 ± 1.42 5.90 ± 2.28 0.937 ‡ Septal E/e’ ratio 6.92 ± 1.82 7.17 ± 3.14 0.616* LA volume (mL/m 2 ) 18.41 ± 4.55 17.50 ± 5.48 0.626 ‡ LVESV (mL) 34 ± 9 38 ± 8 0.086* LVEDV (mL) 106 ± 26 113 ± 17 0.606* LVEF (%) 68 ± 3 68 ± 3 0.763* Right IMT (mm) 0.60 ± 0.12 0.62 ± 0.16 0.481* Left IMT (mm) 0.61 ± 0.14 0.72 ± 0.21 0.018* MEDA > 75 th percentile 6 (18.2%) 3 (27.3%) 0.669 § ELSA >75 th percentile 6 (18.2%) 6 (54.5%) 0.045 § Plaques 9 (27.3%) 5 (45.5%) 0.287 § Peripheral SBP (mmHg) 122.3 ± 11.6 137.1 ± 13.2 0.004 ‡ Peripheral DBP (mmHg) 82.2 ± 8 89.9 ± 8.9 0.022 ‡ MBP (mmHg) 99.2 ± 11.5 108.3 ± 16 0.105 ‡ PP (mmHg) 39.8 ± 6 47.3 ± 11.4 0.058 ‡ Heart rate (bpm) 70 ± 14 72 ± 11 0.989* Central SBP (mmHg) 112.5 ± 10.4 127 ± 13 0.005 ‡ Central DBP (mmHg) 82.2 ± 8.3 91 ± 9.3 0.014 ‡ Central PP (mmHg) 29.3 ± 7 36 ± 8.8 0.020* AIx @75(l/min/m 2 ) 17.64 ± 10.84 19.15 ± 10 0.675 ‡ PWV (m/s) 8 ± 2 9.1 ± 1.8 0.033* *Wilcoxon Mann-Whitney test (mean ± SD), ‡ t-Student (mean ± SD) for independent samples and § Fisher’s exact. IVRT: isovolumic relaxation time; DT: deceleration time; E/A ratio: ratio of the E-wave and A-wave of the left ventricular diastolic filling, LA: left atrial; LVESV: left ventricular end-systolic volume; LVEDV: left ventricular end-diastolic volume; LVEF: left ventricular ejection fraction; IMT: intima-media thickness; MESA: Multi-Ethnic Study of Atherosclerosis; ELSA: Brazilian Longitudinal Study of Adult Health; SBP: systolic blood pressure; DBP: diastolic blood pressure; MBP: mean blood pressure; PP: pulse pressure. AIx @75: Augmentation Index adjusted for a heart rate of 75 beats per minute; PWV: pulse wave velocity. Conclusion Our study shows that psoriatic patients have elevations in carotid IMT and PWV, in addition to increased central and peripheral blood pressure, and serum cholesterol and C-reactive protein levels. Limitations One possible limitation of this study is the small sample size, due to the difficulty in recruiting patients with moderate and severe psoriasis (PASI>7), not using corticosteroids, which could affect the outcome measures. Another possible limitation is the recruitment of patients from one location only. Author contributions Conception and design of the research and Analysis and interpretation of the data: Oliveira AN, Simões MM, Simões R, Rezende BA, Malachias MVB; Acquisition of data: Oliveira AN, Simões MM, Rezende BA, Malachias MVB; Writing of the manuscript and Critical revision of themanuscript for intellectual content: Oliveira AN, Rezende BA, Malachias MVB. Potential Conflict of Interest No potential conflict of interest relevant to this article was reported. Sources of Funding There were no external funding sources for this study. Study Association This article is part of the thesis of master submitted by Angélica Navarro de Oliveira, from Faculdade de Ciências Medicas de Minas Gerais. Ethics approval and consent to participate This study was approved by the Ethics Committee of the Faculdade de Ciências Médicas de Minas Gerais under the protocol number 1.267.197. All the procedures in this study were in accordance with the 1975 Helsinki Declaration, updated in 2013. Informed consent was obtained from all participants included in the study. 246