ABC | Volume 113, Nº2, August 2019

Original Article Casonatto et al. Citrulline and post-exercise hypotension Arq Bras Cardiol. 2019; 113(2):218-228 10. Bonsu B, Terblanche E. The training and detraining effect of high-intensity interval training on post-exercise hypotension in young overweight/obese women. Eur J Appl Physiol. 2016;116(1):77-84. 11. Lima AH, Miranda AS, CorreiaMA, Soares AH, CucatoGG, Sobral FilhoDC, et al. Individual blood pressure responses towalking and resistance exercise in peripheral artery disease patients: are themean values describing what is happening? J Vasc Nurs. 2015;33(4):150-6. 12. Buford TW, Roberts MD, Church TS. Toward exercise as personalized medicine. Sports Med. 2013;43(3):157-65. 13. Breuillard C, Cynober L, Moinard C. Citrulline and nitrogen homeostasis: an overview. Amino Acids. 2015;47(4):685-91. 14. Floras JS, Wesche J. Haemodynamic contributions to post-exercise hypotension in young adults with hypertension and rapid resting heart rates. J HumHypertens. 1992;6(4):265-9. 15. Coats AJ, Conway J, Isea JE, Pannarale G, Sleight P, Somers VK. Systemic and forearm vascular resistance changes after upright bicycle exercise in man. J Physiol. 1989 Jun;413:289-98. 16. Isea JE, Piepoli M, Adamopoulos S, Pannarale G, Sleight P, Coats AJ. Time course of haemodynamic changes after maximal exercise. Eur J Clin Invest. 1994;24(12):824-9. 17. Coelho-Junior HJ, Irigoyen MC, Aguiar SDS, Goncalves IO, Camara NOS, Cenedeze MA, et al. Acute effects of power and resistance exercises on hemodynamic measurements of older women. Clin Interv Aging. 2017 Jul 11;12:1103-14. 18. Santana HA, Moreira SR, Asano RY, Sales MM, Cordova C, Campbell CS, et al. Exercise intensity modulates nitric oxide and blood pressure responses in hypertensive older women. Aging Clin Exp Res. 2013;25(1):43-8. 19. Asano RY, Browne RAV, Sotero RC, Sales MM, Moraes JFVN, Campbell CS, et al. Cycling above rather than below lactate threshold is more effective for nitric oxide release and post-exercise blood pressure reduction in individuals with type-2 diabetes. Motriz. 2013;19(3):633-40. 20. Simoes HG, Asano RY, Sales MM, Browne RA, Arsa G, Motta-Santos D, et al. Type2diabeteselicitslowernitricoxide,bradykininconcentrationandkallikrein activitytogetherwithhigherDesArg(9)-BKandreducedpost-exercisehypotension comparedtonon-diabeticcondition.PloSOne.2013;8(11):e80348. 21. Allerton TD, Proctor DN, Stephens JM, Dugas TR, Spielmann G, Irving BA. l-Citrulline supplementation: impact on cardiometabolic health. Nutrients. 2018;10(7):pii: E921. 22. Borg G. Borg’s perceived exertion and pain scales. Champaign: Human Kinetics; 1998. 23. GordonCC,ChumleaWC,RocheAF.Stature,recumbent length,andweight. In: Lohman TG, Roche AF, Martorell R, editors. Champaign: Human Kinetics Books; 1988. 3-8 p. 24. Coleman A, Freeman P, Steel S, Shennan A. Validation of the Omron MX3 Plus oscillometric blood pressure monitoring device according to the EuropeanSocietyofHypertension internationalprotocol.BloodPressMonit. 2005;10(3):165-8. 25. Pickering TG, Hall JE, Appel LJ, Falkner BE, Graves J, Hill MN, et al. Recommendations for blood pressure measurement in humans and experimental animals: part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the AmericanHeart Association Council onHigh Blood Pressure Research. Circulation. 2005;111(5):697-716. 26. Casonatto J, Tinucci T, DouradoAC, PolitoM. Cardiovascular and autonomic responses after exercise sessions with different intensities and durations. Clinics (Sao Paulo). 2011;66(3):453-8. 27. Haley SM, Fragala-Pinkham MA. Interpreting change scores of tests and measures used in physical therapy. Phys Ther. 2006;86(5):735-43. 28. Darter BJ, Rodriguez KM, Wilken JM. Test-retest reliability and minimum detectable change using the K4b2: oxygen consumption, gait efficiency, and heart rate for healthy adults during submaximal walking. Res QExerc Sport. 2013;84(2):223-31. 29. Mann TN, Lamberts RP, Lambert MI. High responders and low responders: factors associated with individual variation in response to standardized training. Sports Med. 2014;44(8):1113-24. 30. Vickers AJ. The use of percentage change from baseline as an outcome in a controlled trial is statistically inefficient: a simulation study. BMC Med Res Methodol. 2001;1:6. 31. Sullivan GM, Feinn R. Using effect size-or why the P value is not enough. J Grad Med Educ. 2012;4(3):279-82. 32. Lakens D. Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs. Front Psychol. 2013 Nov 26;4:863. 33. Luttrell MJ, Halliwill JR. Recovery from exercise: vulnerable state, window of opportunity, or crystal ball? Front Physiol. 2015 Jul 22;6:204. 34. Schwedhelm E, Maas R, Freese R, Jung D, Lukacs Z, Jambrecina A, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol. 2008;65(1):51-9. 35. Mori M. Regulation of nitric oxide synthesis and apoptosis by arginase and arginine recycling. J Nutr. 2007;137(6 Suppl 2):1616S-20S. 36. McKinley-Barnard S, Andre T, Morita M, Willoughby DS. Combined L-citrulline and glutathione supplementation increases the concentration of markers indicative of nitric oxide synthesis. J Int Soc Sports Nutr. 2015 Jun 10;12:27. 37. Kim IY, Schutzler SE, Schrader A, Spencer HJ, Azhar G, DeutzNE, et al. Acute ingestion of citrulline stimulates nitric oxide synthesis but does not increase blood flow in healthy young and older adults with heart failure. Am J Physiol Endocrinol Metab. 2015;309(11):E915-24. 38. BaileySJ,BlackwellJR,LordT,VanhataloA,WinyardPG,JonesAM. l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans. J Appl Physiol (1985). 2015;119(4):385-95. 39. Ochiai M, Hayashi T, Morita M, Ina K, Maeda M, Watanabe F, et al. Short- term effects of L-citrulline supplementation on arterial stiffness in middle- aged men. Int J Cardiol. 2012;155(2):257-61. 40. WongA,Alvarez-AlvaradoS, JaimeSJ,KinseyAW,SpicerMT,MadzimaTA,et al.Combinedwhole-bodyvibrationtrainingand l-citrullinesupplementation improves pressure wave reflection in obese postmenopausal women. Appl Physiol Nutr Metab. 2016;41(3):292-7. 41. Hecksteden A, Kraushaar J, Scharhag-Rosenberger F, Theisen D, Senn S, Meyer T. Individual response to exercise training - a statistical perspective. J Appl Physiol (1985). 2015;118(12):1450-9. 42. Swinton PA, Hemingway BS, Saunders B, Gualano B, Dolan E. A statistical framework to interpret individual response to intervention: paving the way for personalizednutritionandexerciseprescription.FrontNutr.2018May28;5:41. 227

RkJQdWJsaXNoZXIy MjM4Mjg=