ABC | Volume 113, Nº2, August 2019

Original Article Yan et al. The effect of LP(a) on chronic heart failure Arq Bras Cardiol. 2019; 113(2):197-204 Figure 1 – Kaplan-Meier curve for recurrent HF free rate according to Lp(a) levels. HF: heart failure. 1.00 0.75 0.50 0.25 0.00 < 20.6 ≥ 20.6 < 20.6 ≥ 20.6 0 Recurrent HF free rate (%) 154 155 0 100 200 300 123 97 111 43 86 18 100 200 Days Days 300 Log-Rank p < 0.0001 Number at risk Table 2 – Clinical outcomes Variables Low-Lp (a) Group (n = 154) High-Lp (a) Group (n = 155) RR 95% CI p value Recurrent HF 79 (51.3) 121 (78.1) 1.52 1.28-1.81 < 0.0001 Ischemic stroke 1 (0.6) 3 (1.9) 2.98 0.31-28.34 0.3419 ACS 1 (0.6) 5 (3.2) 4.97 0.59-42.03 0.1412 NSTEMI 0 (0) 2 (1.3) 4.97 0.24-102.65 0.2995 STEMI 1 (0.6) 3 (1.9) 2.98 0.31-28.34 0.3419 Cardiac death 0 (0) 2 (1.3) 4.97 0.24-102.65 0.2995 ACS: acute coronary syndrome; CI: confidence interval; HF: heart failure; NSTEMI: non-ST-segment elevation myocardial infarction; RR: relative risk; STEMI: ST‑segment elevation myocardial infarction. Data are presented as n (%). subtypes comprised of a single copy of KIV1, multiple copies of KIV2, a single copy of KIV3 ~ 10. 12 Lp(a) levels are genetically determined by the variation of the copy number of kringle IV type 2 (KIV-2) repeats on the LPA gene and various single nucleotide polymorphisms. 25 The number of repeats was inversely associated with Lp(a) levels. 25 In addition, Frischmann et al. 26 observed that increased plasma LP(a) levels were associated with renal dysfunction. In our study, the 201