ABC | Volume 113, Nº2, August 2019

Original Article Yan et al. The effect of LP(a) on chronic heart failure Arq Bras Cardiol. 2019; 113(2):197-204 Table 1 – Baseline characteristics of the study population Variables All patients (n = 309) Low-Lp (a) Group (n = 154) High-Lp (a) Group (n = 155) p value Age (years) 68.6 ± 11.6 68.5 ± 11.7 68.8 ± 11.6 0.833 Male gender (%) 174 (56.3) 79 (51.3) 95 (61.3) 0.077 Current smokers (%) 72 (23.3) 31 (20.1) 41 (26.5) 0.189 Alcohol intake (%) 15 (4.9) 6 (3.9) 9 (5.8) 0.435 Heart rate (beats/min) 81.6 ± 18.5 81.7 ± 18.0 81.5 ± 19.1 0.920 BMI (kg/m 2 ) 21.9 ± 4.5 22.4 ± 4.5 21.5 ± 4.5 0.087 SBP (mmHg) 142.5 ± 28.1 146.0 ± 29.3 139.0 ± 26.4 0.801 NYHA class (%) < 0.001 II 154 (49.8) 103 (66.9) 51 (32.9) III 102 (33.0) 32 (20.8) 70 (45.2) IV 53 (17.2) 19 (12.3) 34 (21.9) Potassium (mmol/L) 3.9 ± 0.4 3.9 ± 0.4 4.0 ± 0.4 0.754 Sodium (mmol/L) 141.1 ± 4.2 141.2 ± 3.9 141.0 ± 4.4 0.633 Hemoglobin (g/dL) 131.0 ± 17.8 130.6 ± 16.3 131.2 ± 19.2 0.760 NT-proBNP (pg/ml) 3109.0 (1500.0-6313.0) 1534.5 (1075.0-2523.5) 5977.0 (3222.0-8835.0) < 0.001 LN-NT-proBNP (pg/ml*) 8.0 ± 0.8 7.4 ± 0.7 8.6 ± 0.6 < 0.001 LVEF (%) 48.3 ± 4.2 49.2 ± 3.8 47.4 ± 4.4 < 0.001 eGFR (mL/min/1.73 m 2 ) 85.3 ± 29.8 88.4 ± 28.1 82.1 ± 31.1 0.063 TC (mg/dL) 156.7 (129.7-190.4) 161.0 (135.3-187.9) 156.0 (127.3-191.9) 0.974 Lp(a) (mg/dL) 20.6 (12.0-35.3) 12.0 (7.6-16.6) 35.3 (25.4-52.0) < 0.001 HDL-C (mg/dL) 42.6 (36.4-50.3) 42.8 (36.1-50.3) 42.6 (37.0-49.5) 0.762 LDL-C (mg/dL) 90.3 (72.6-118.1) 92.1 (74.9-111.2) 88.4 (64.3-121.8) 0.609 TG (mg/dL) 117.8 (82.3-167.3) 125.7 (81.5-189.5) 112.5 (83.7-155.4) 0.133 LAD lesion(%) 278 (90.0) 137 (89.0) 141 (91.0) 0.557 Two lesions(%) 91 (29.4) 41 (26.6) 50 (32.3) 0.277 Multiple lesions(%) 89 (28.8) 34 (22.1) 55 (35.5) 0.009 Number of stents (%) < 0.001 0 141 (45.6) 87 (56.5) 54 (34.8) 1 96 (31.0) 47 (30.5) 49 (31.6) 2 50 (16.2) 11 (7.1) 39 (25.2) 3 14 (4.5) 5 (3.2) 9 (5.8) 4 8 (2.6) 4 (2.6) 4 (2.6) History of DM(%) 130 (42.1) 57 (37.0) 73 (47.1) 0.073 AF(%) 32 (10.4) 18 (11.7) 14 (9.0) 0.444 Hypertension (%) 251 (81.2) 131 (85.1) 120 (77.4) 0.085 Prior MI(%) 91 (29.4) 33 (21.4) 58 (37.4) 0.002 Prior CABG(%) 2 (0.6) 2 (1.3) 0 (0.0) 0.475 Prior PCI(%) 164 (53.1) 66 (42.9) 98 (63.2) <0.001 Medications at discharge Diuretics (%) 183 (59.2) 88 (57.1) 95 (61.3) 0.458 Digoxin (%) 12 (3.9) 5 (3.2) 7 (4.5) 0.564 ACEI/ARBs (%) 285 (92.2) 140 (90.9) 145 (93.5) 0.386 199