ABC | Volume 113, Nº1, July 2019

Original Article Sincer et al Mean platelet volume, coronary artery fistula Arq Bras Cardiol. 2019; 113(1):71-76 Figure 1 – Diagonal segments are produced by ties. ROC Curve Sensitivity 1 – Specificity 1.0 1.0 0.8 0.8 0.6 0.6 0.4 0.4 0.2 0.2 0.0 0.0 Diagonal segments are produced by ties. Table 3 – Echocardiographic findings of the study population Variables Fistula Control p Left ventricle end-diastolic diameter(cm) 4.7 ± 0.65 4.6 ± 0.53 0.22 Left ventricle end-systolic diameter(cm) 3.4 ± 0.86 3.3 ± 0.72 0.123 Ejection Fraction (%) 61.4 ± 8.9 63.1 ± 0.76 0.11 Right ventricle end-diastolic diameter(cm) 2.87 ± 0.81 2.46 ± 0.4 0.04 Left atrium diameter(cm) 3.3 ± 0.64 3.4 ± 0.71 0.19 phase reactants can suppress the dimensions of platelets by interfering with the process of megakaryopoiesis in the bone marrow. 13 HDL-cholesterol was found to have a modulating effect on endothelial dysfunction through antioxidant and anti‑inflammatory effects. 21 Reduced HDL-cholesterol levels in CAF subjects, when compared to controls, may be the underlying cause of endothelial dysfunction in CAF, but prospective studies are still needed to confirm that. The retrospective cross-sectional design and single-center nature are two important limitations of the present report. Another limitation could be the relatively small study cohort. As far as we know, there are no data about the association of inflammation and CAF. The lack of analysis of inflammatory markers is another important limitation. However, to the best of knowledge, this is the first study that reported an association between CAF and MPV. Conclusion The present study suggests that lower MPV may be associated with CAF. Although an elevated MPV is well established in conditions with higher cardiovascular mortality, this is the first time lower MPV was found in a cardiac disease with low mortality. Therefore, we suggest the use of MPV to determine CAF in patients, considering it is a cost-effective and simple test. 74