ABC | Volume 113, Nº1, July 2019

Statement Statement on Antiplatelet Agents and Anticoagulants in Cardiology – 2019 Arq Bras Cardiol. 2019; 113(1):111-134 6- versus 12-month dual antiplatelet therapy: the SECURITY randomized clinical trial. J Am Coll Cardiol. 2014;64(20):2086-97. 37. Lee CW, Ahn JM, Park DW, Kang SJ, Lee SW, Kim YH, et al. Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: a randomized, controlled trial. Circulation. 2014;129(3):304-12. 38. Collet JP, Silvain J, Barthelemy O, Range G, Cayla G, Van Belle E, et al; ARCTIC investigators. Dual-antiplatelet treatment beyond 1year after drug-eluting stent implantation (ARCTIC-Interruption): a randomised trial. Lancet. 2014;384(9954):1577-85. 39. Bittl JA, Baber U, Bradley SM, Wijeysundera DN. Duration of dual antiplatelet therapy: a systematic review for the 2016 ACC/AHAGuideline focused update on duration of dual antiplatelet therapy in patients with coronary artery disease: a report of the American College of Cardiology/ American Heart Association Task Force on clinical practice guidelines. J Am Coll Cardiol. 2016;68(10):1116-39. 40. Wallentin L, Becker RC, Budaj A, Cannon CP, Emanuelsson H, Held C, et al.Ticagrelorversusclopidogrel inpatientswithacutecoronarysyndromes. N Engl J Med. 2009;361(11):1045-57. 41. Montalescot G, Wiviott SD, Braunwald E, Murphy SA, Gibson CM, McCabeCH,etal;TRITON-TIMI38 investigators.Prasugrelcomparedwith clopidogrel in patients undergoing percutaneous coronary intervention for ST- elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trial. Lancet. 2009;373(9665):723-31. 42. Palmerini T, Della Riva D, Benedetto U, Reggiani LB, Feres F, Abizaid A, et al. Three, six or twelve months of dual antiplatelet therapy after drug-eluting stent implantation in patients with or without acute coronary syndromes: an individual patient data pairwise and network meta-analysis of six randomized trials and 11 473 patients. Eur Heart J. 2017;38(14):1034-43. 43. Bonaca MP, Bhatt DL, Cohen M, Steg PG, Storey RF, Jensen EC, et al; PEGASUS-TIMI 54 Steering Committee and Investigators. Long-term use of ticagrelor in patients with prior myocardial infarction. N Engl J Med. 2015;372(19):1791-800. 44. Ruff CT, Giugliano RP, Braunwald E, Hoffman EB, Deenadayalu N, Ezekowitz MD, et al. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta- analysis of randomised trials. Lancet. 2014;383(9921):955-62. 45. MajeedA,HwangHG,ConnollySJ,EikelboomJW,EzekowitzMD,Wallentin L,etal.Managementandoutcomesofmajorbleedingduringtreatmentwith dabigatran or warfarin. Circulation. 2013;128(21):2325-32. 46. Raval AN, Cigarroa JE, ChungMK, Diaz-Sandoval LJ, Diercks D, Piccini JP, et al; AmericanHeart AssociationClinical Pharmacology Subcommittee of the Acute Cardiac Care andGeneral Cardiology Committee of the Council on Clinical Cardiology; Council on Cardiovascular Disease in the Young; and Council on Quality of Care and Outcomes Research. Management of patients on non-vitamin K antagonist oral anticoagulants in the acute care and periprocedural setting: a scientific statement from the American Heart Association. Circulation. 2017;135(10):e604-e633. Erratum in: Circulation. 2017;135(10):e647; Circulation. 2017;135(24):e1144. 47. Levy JH, Ageno W, Chan NC, Crowther M, Verhamme P, Weitz JI; Subcommittee on Control of Anticoagulation. When and how to use antidotes for the reversal of direct oral anticoagulants: guidance from the SSC of the ISTH. J Thromb Haemost. 2016;14(3):623-7. 48. PollackCV Jr,ReillyPA,Eikelboom J,GlundS,VerhammeP,BernsteinRA,et al.Idarucizumabfordabigatranreversal.NEnglJMed.2015;373(6):511-20. 49. Siegal DM, Curnutte JT, Connolly SJ, Lu G, Conley PB, Wiens BL, et al. Andexanet alfa for the reversal of factor Xa inhibitor activity. N Engl J Med. 2015;373(25):2413-24. 50. Connolly SJ, Milling TJ Jr, Eikelboom JW, Gibson CM, Curnutte JT, Gold A, et al; ANNEXA-4 Investigators. Andexanet alfa for acute major bleeding associatedwith factor Xa inhibitors. NEngl J Med. 2016;375(12):1131-41. 51. Stevenson JW, Minns AB, Smollin C, Albertson TE, Cantrell FL, Tomaszewski C, et al. An observational case series of dabigatran and rivaroxaban exposures reported to a poison control system. Am J Emerg Med. 2014;32(9):1077-84. 52. Lehmann T, Hofer KE, Baumann M, Hasler K, Ceschi A, Kupferschmidt H, et al. Massive human rivaroxaban overdose. Thromb Haemost. 2014;112(4):834-6. 53. Dibu JR,Weimer JM, Ahrens C, Manno E, Frontera JA. The role of FEIBA in reversing novel oral anticoagulants in intracerebral hemorrhage. Neurocrit Care. 2015;24(3):413-9. 54. Perzborn E, Heitmeier S, Laux V, Buchmuller A. Reversal of rivaroxaban- induced anticoagulation with prothrombin complex concentrate, activated prothrombin complex concentrate and recombinant activated factor VII in vitro. Thromb Res. 2014;133(4):671-81. 55. SchultzNH, TranHTT, Bjørnsen S, HenrikssonCE, Sandset PM, Holme PA. The reversal effect of prothrombin complex concentrate (PCC), activated PCC and recombinant activated factor VII against anticoagulation of Xa inhibitor. Thromb J. 2017 Feb 20;15:6. 56. Eerenberg ES, Kamphuisen PW, Sijpkens MK, Meijers JC, Buller HR, Levi M. Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate:arandomized,placebo-controlled,crossoverstudy inhealthy subjects. Circulation. 2011;124(14):1573-9. 57. Gehrie E, Tormey C. Novel oral anticoagulants: efficacy, laboratory measurement, and approaches to emergent reversal. Arch Pathol Lab Med. 2015;139(5):687-92. 58. Zimerman LI, Fenelon G, Martinelli Filho M, Grupi C, AtiéJ, Lorga Filho A, et al; Sociedade Brasileira de Cardiologia. Diretrizes brasileiras de fibrilação atrial. Arq Bras Cardiol. 2009;92(6 supl 1):1-39. 59. Magalhães LP, Figueiredo MJ, Cintra FD, Saad EB, Kuniyishi RR, Teixeira RA, et al. II Diretrizes brasileiras de fibrilação atrial. Arq Bras Cardiol. 2016;106(4 Supl.2):1-22. 60. Benjamin EJ, Wolf PA, D’Agostino RB, Silbershatz H, Kannel WB, Levy D. Impact of atrial fibrillation on the risk of death: the FraminghamHeart Study. Circulation. 1998;98(10):946-52. 61. Psaty BM, Manolio TA, Kuller LH, Kronmal RA, Cushman M, Fried LP, et al. Incidence of and risk factors for atrial fibrillation in older adults. Circulation. 1997;96(7):2455-61. 62. Soliman EZ, Prineas RJ, Case LD, Zhang Z, Goff DC Jr. Ethnic distribution of ECG predictors of atrial fibrillation and its impact on understanding the ethnic distribution of ischemic stroke in the Atherosclerosis Risk in Communities (ARIC) study. Stroke. 2009;40(4):1204-11. Erratum in: Stroke. 2010;41(5):e433. 63. FeinbergWM, Blackshear JL, Laupacis A, Kronmal R, Hart RG. Prevalence, age distribution, and gender of patients with atrial fibrillation: analysis and implications. Arch Intern Med. 1995;155(5):469-73. 64. Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke. 1991;22(8):983-8. 65. Gorter JW. Major bleeding during anticoagulation after cerebral ischemia: patterns and risk factors. Stroke Prevention In Reversible Ischemia Trial (SPIRIT). European Atrial Fibrillation Trial (EAFT) study groups. Neurology. 1999;53(6):1319-27. 66. Watson T, Kakar P, Lip GY. Stroke risk stratification in atrial fibrillation: something to EXAMINE more closely. Int J Clin Pract. 2007;61(1):6-9. Erratum in: Int J Clin Pract. 2007;61(3):534. 67. Das RR, Seshadri S, Beiser AS, Kelly-Hayes M, Au R, Himali JJ. Prevalence and correlates of silent cerebral infarcts in the FraminghamOffspring Study. Stroke. 2008;39(11):2929-35. 68. ShermanDG. Stroke prevention in atrial fibrillation: pharmacological rate versus rhythm control. Stroke. 2007;38(2 Suppl):615-7. 69. Wyse DG, Waldo AL, DiMarco JP, Domanski MJ, Rosenberg Y, Schron EB, et al; Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Investigators. A comparison of rate control and rhythm control in patients with atrial fibrillation. N Eng J Med. 2002;347(23):1825-33. 70. January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Cleveland JC Jr, et al; ACC/AHA Task Force Members. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: executive summary: 129