ABC | Volume 112, Nº5, May 2019

Original Article Gomes et al Thermoregulation in hypertensive rats Arq Bras Cardiol. 2019; 112(5):534-542 Figure 4 – Heat accumulation (HA, A) and heat accumulation/work ratio (HA/W, B). Data expressed as mean ± SD; # p < 0.05: T-WIS vs. C-WIS. + p < 0.05: T-SHR vs. T-WIS, C-WIS: control Wistar, T-WIS: trained Wistar, C-SHR: control SHR, T-SHR: trained SHR. 400 # + 500 300 200 100 0 C-WIS T-WIS T-SHR C-SHR C-WIS T-WIS T-SHR C-SHR HA (Cal/100 g) A 0.5 0.6 0.4 0.2 0.3 0.1 0.0 HA/W (Cal.J –1 ) B 1. Webb P. The physiology of heat regulation. Am J Physiol. 1995;268(4 Pt 2):R838-50. 2. Gleeson M. Temperature regulation during exercise. Int J Sports Med. 1998;19(Suppl 2):S96-9. 3. Fuller A, Carter RN, Mitchell D. Brain and abdominal temperatures at fatigue in rats exercising in the heat. J Appl Physiol. 1998;84(3):877-83. 4. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA. 2003;289(19):2560-72. 5. TrippodoNC,FrohlichED.Similaritiesofgenetic(spontaneous)hypertension. Man and rat. Circ Res. 1981;48(3):309-19. 6. Cerbai E, Barbieri M, Li Q, Mugelli A. Ionic basis of action potential prolongation of hypertrophied cardiacmyocytes isolated fromhypertensive rats of different ages. Cardiovasc Res. 1994;28(8):1180-7. 7. Campos HO, Leite LH, Drummond LR, Cunha DN, Coimbra CC, Natali AJ, et al. Temperature control of hypertensive rats during moderate exercise in warm environment. J Sports Sci Med. 2014;13(3):695-701. 8. Drummond LR, Kunstetter AC, Vaz FF, Campos HO, Andrade AGP, Coimbra CC, et al. Brain temperature in Spontaneously Hypertensive Rats during physical exercise in temperate and warm environments. Plos One. 2016;11(5):e0155919. 9. Véras-Silva AS, Mattos KC, Gava NS, BrumPC, Negrão CE, Krieger EM. Low intensity exercise training decreases cardiac output and hypertension in spontaneously hypertensive rats. Am J Physiol. 1997;273(6 Pt 2):H2627-31. 10. Carneiro-Júnior MA, Quintão-Júnior JF, Drummond LR, Lavorato VN, Drummond FR, Cunha DN, et al. The benefits of endurance training in cardiomyocyte function in hypertensive rats are reversedwithin four weeks of detraining. J Mol Cell Cardiol. 2013 Apr;57:119-28. 11. Armitage P, Berry G. Statistical methods in medical research. Oxford: Blackwell; 1987. 12. Lavorato VN, Del Carlo RJ, Cunha DN, Okano BS, Belfort FG, De Freitas JS, et al. Mesenchymal stem cell therapy associated with endurance exercise training: effects on the structural and functional remodeling of infarcted rat hearts . J Mol Cell Cardiol. 2016 Jan;90:111-9. 13. Prímola-Gomes TN, Pires W, Rodrigues LO, Coimbra CC, Marubayashi U, Lima NR. Activation of the central cholinergic pathway increases post- exercise tail heat loss in rats. Neurosci Lett. 2007;413(1):1-5. 14. PiresW, Wanner SP, La Guardia RB, Rodrigues LO, Silveira AS, Coimbra CC, et al. Intracerebroventricular physostigmine enhances blood pressure and heat loss in running rats. J Physiol Pharmacol. 2007;58(1):3-17. References 540